Estimating the true incidence of campylobacteriosis and salmonellosis in the European Union, 2009

Havelaar, Arie H.; Ivarsson, Sofie; Löfdahl, Margareta; Nauta, Maarten

doi:10.1017/s0950268812000568

Cited by 169 publications

(152 citation statements)

References 10 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…The most current evaluation of the epidemiology of campylobacteriosis in 27 European Union (EU) state members indicated the incidences of Campylobacter infections to range from 29.9 to 13,500 per 100,000 population in 2009 (with the lowest incidences in Finland and Sweden and the highest in Bul-garia) (46). Overall, this equated to 9.2 million cases, compared to 6.2 million cases of salmonellosis, in 2009 (46). A United Kingdom-wide study conducted over the period from April 2008 to August 2009 identified Campylobacter species as the most common bacterial pathogens in cases of gastroenteritis (47).…”

Section: Epidemiologymentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

View full text Add to dashboard Cite

SUMMARY Campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. The incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. The dramatic increase in North America, Europe, and Australia is alarming, and data from parts of Africa, Asia, and the Middle East indicate that campylobacteriosis is endemic in these areas, especially in children. In addition to C. jejuni , there is increasing recognition of the clinical importance of emerging Campylobacter species, including Campylobacter concisus and Campylobacter ureolyticus . Poultry is a major reservoir and source of transmission of campylobacteriosis to humans. Other risk factors include consumption of animal products and water, contact with animals, and international travel. Strategic implementation of multifaceted biocontrol measures to reduce the transmission of this group of pathogens is paramount for public health. Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come. This review provides a comprehensive overview of the global epidemiology, transmission, and clinical relevance of Campylobacter infection.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The potential benefit of an algorithm-based surveillance can be appreciated in the light of the relatively low number of reported Salmonella outbreaks in Israel, with only a single outbreak recognized in 2010 (31), while our analysis estimated that each year in Israel there are on average 23 potential outbreaks. If one takes into account the EU multiplier for the ratio of underdiagnosis of 58 for every laboratory-confirmed case (32), it is likely that the actual number of outbreaks in the community is even higher. Statistical surveillance methods such as the Farrington algorithm provide an economical, efficient, and valid tool for early detection of potential outbreaks that require further epidemiological investigation and confirmation.…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of Salmonellosis in Israel Reveals Association of Salmonella enterica Serovar 9,12:l,v:− with Extraintestinal Infections, Dissemination of Endemic S. enterica Serovar Typhimurium DT104 Biotypes, and Severe Underreporting of Outbreaks

et al. 2014

View full text Add to dashboard Cite

f Salmonella enterica is the leading etiologic agent of bacterial food-borne outbreaks worldwide. This ubiquitous species contains more than 2,600 serovars that may differ in their host specificity, clinical manifestations, and epidemiology. To characterize salmonellosis epidemiology in Israel and to study the association of nontyphoidal Salmonella (NTS) serovars with invasive infections, 48,345 Salmonella cases reported and serotyped at the National Salmonella Reference Center between 1995 and 2012 were analyzed. A quasi-Poisson regression was used to identify irregular clusters of illness, and pulsed-field gel electrophoresis in conjunction with whole-genome sequencing was applied to molecularly characterize strains of interest. Three hundred twenty-nine human salmonellosis clusters were identified, representing an annual average of 23 (95% confidence interval [CI], 20 to 26) potential outbreaks. We show that the previously unsequenced S. enterica serovar 9,12:l,v:؊ belongs to the B clade of Salmonella enterica subspecies enterica, and we show its frequent association with extraintestinal infections, compared to other NTS serovars. Furthermore, we identified the dissemination of two prevalent Salmonella enterica serovar Typhimurium DT104 clones in Israel, which are genetically distinct from other global DT104 isolates. Accumulatively, these findings indicate a severe underreporting of Salmonella outbreaks in Israel and provide insights into the epidemiology and genomics of prevalent serovars, responsible for recurring illness.

show abstract

“…Therefore countryspecific MFs should be used if possible [14,64,65]. The MFs estimated in this paper are the only ones available based on Swedish data, and these are therefore considered to be the most accurate estimates available.…”

Section: Discussionmentioning

confidence: 99%

A Systematic and Critical Review of Model-Based Economic Evaluations of Pharmacotherapeutics in Patients with Bipolar Disorder

Mohiuddin

2014

Appl Health Econ Health Policy

View full text Add to dashboard Cite

Objectives The main objective of this study was to derive cost estimates of five major foodborne illnesses (campylobacteriosis, salmonellosis, enterohemorrhagic Escherichia coli (EHEC), yersiniosis and shigellosis) in Sweden. These estimates provide a necessary contribution to perform future cost-benefit analyses aimed at reducing the burden of foodborne disease. A secondary aim was to obtain estimates of the true number of cases that occur in the community, thus providing necessary ground for calculating costs. Methods The true number of cases for each foodborne illness was simulated by multiplying the reported number of cases by sequential multipliers, one for each potential source of information loss about a case. This assessment of the true number of cases was then used to estimate the number of cases of sequelae for each illness. An incidence-based analysis was then used to calculate direct medical and non-medical costs, as well as indirect costs. Data for estimating the true number of cases for each illness were primarily based on an expert panel, while the derivation of costs mainly utilized national registries, databases and published literature. Results The estimated number of cases was between 7-and 11-fold higher than the reported number of cases, indicating the importance of taking information loss into account when calculating costs. By far the most common pathogen of the five was campylobacter, with an estimated 101,719 (90% credibility interval [CI] 59,640-158,025) human cases occurring annually. For salmonella, 19,678 (90% CI 8394-40,456) cases were estimated to occur each year, while the other three pathogens were less common, with a yearly incidence of approximately 2500-5500 cases each. The total cost for the five pathogens (including sequelae) amounted to €142 million annually. Campylobacter was the most costly pathogen, representing 69% of the total costs. Salmonellosis and EHEC constituted 18 and 9% of these costs, respectively, while yersiniosis and shigellosis represented approximately 2% each. Costs for sequelae were significant and accounted for approximately 50% of the total costs. Conclusions Our simulations indicated that campylobacter infection was more common and more costly than salmonella, EHEC, yersinia and shigella combined. Estimated costs for all illnesses were highly influenced by (1) considering potential information losses about cases in the population (which increased costs 7-to 11-fold), and (2) taking account of postinfection sequelae (which doubled the costs). Key Points for Decision MakersThis study estimates the difference between registered and actual number of cases in the community for five major foodborne diseases. Potential post-infection sequelae are included in the analysis. These considerations are crucial in order to assess the actual societal burden of the five pathogens.The study also estimates total societal costs and costs per case for the five pathogens, results that can be utilized in future cost-benefit or cost-effectiveness studies.

show abstract

Estimating the true incidence of campylobacteriosis and salmonellosis in the European Union, 2009

Cited by 169 publications

References 10 publications

Global Epidemiology of Campylobacter Infection

Global Epidemiology of Campylobacter Infection

Integrative Analysis of Salmonellosis in Israel Reveals Association of Salmonella enterica Serovar 9,12:l,v:− with Extraintestinal Infections, Dissemination of Endemic S. enterica Serovar Typhimurium DT104 Biotypes, and Severe Underreporting of Outbreaks

A Systematic and Critical Review of Model-Based Economic Evaluations of Pharmacotherapeutics in Patients with Bipolar Disorder

Contact Info

Product

Resources

About