Estimating the mortality rate of hepatitis C using multiple data sources

Wu, Chen‐Ta; Chang, Horng-Rong; McNutt, Louise Anne; Smith, Perry F.

doi:10.1017/s0950268804003103

Cited by 18 publications

(13 citation statements)

References 14 publications

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“…Very few surveys are published on HBV and HCV infection-related mortality. One study from the United States (New York state excluding New York City) was based on a population of 491 deaths identified in 1997 using multiple data sources (hospital discharge database and cause-of-death file) and found an HCV infection-related mortality rate of 4.5 per 100,000 (6.1 for men and 2.9 for women) [22]. These results correlate well with the data from the present study.…”

Section: Discussionsupporting

confidence: 87%

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Marcellin

Péquignot

Delarocque-Astagneau

et al. 2008

Journal of Hepatology

139

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Section: Discussionsupporting

confidence: 87%

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Marcellin

Péquignot

Delarocque-Astagneau

et al. 2008

Journal of Hepatology

139

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“…The present study has several limitations. First, we used NDI data (based on death certificates) to classify deaths as liver-related, therefore there may have been misclassification of the cause of deaths [16,53]. We expect that this misclassification would be nondifferential with regard to HCV status, although it is possible that the person coding the death certificate might be more likely to select a liver-related cause given a range of possible contributing causes of death, which would bias in favor of the observed association.…”

Section: Discussionmentioning

confidence: 99%

Chronic hepatitis C virus infection is associated with all‐cause and liver‐related mortality in a cohort of HIV‐infected patients with alcohol problems

et al. 2013

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Aims To assess the association between hepatitis C virus (HCV) infection and overall and liver-related death in human immunodeficiency virus (HIV)-infected patients with alcohol problems. Design We analyzed data from a cohort of HIV-infected adults with current or past alcohol problems enrolled between 2001 and 2003, searching for causes of death until 2010 using the National Death Index. Setting and participants Participants were HIV-infected adults with current or past alcohol problems, recruited in Boston, MA from HIV clinics at two hospitals, homeless shelters, drug treatment programs, subject referrals, flyers, and another cohort study with comparable recruitment sites. Measurements The primary and secondary outcomes were all-cause and liver-related mortality, respectively. The main independent variable was HCV RNA status (positive vs. negative). Mortality rates and Kaplan-Meier survival curves were calculated by HCV status for both overall and liver-related mortality. Cox proportional hazards models were used to assess the association between HCV infection and overall and liver-related death, adjusting for alcohol and drug use over time. Findings 397 adults (50% HCV-infected) were included. As of December 31, 2009, 83 cohort participants had died (60 HCV-infected, 23 HCV-uninfected; log rank test p<0.001), and 26 of those deaths were liver-related (21 HCV-infected, 5 HCV-uninfected; log rank test p<0.001). All-cause and liver-related mortality rates were 4.68 and 1.64 deaths per 100 person-years for HCV-infected patients and 1.65 and 0.36 per 100 person-years for those without HCV, respectively. In the fully adjusted Cox model, HCV infection was associated with both overall [HR 2.55 (95%CI:1.50–4.33), p<0.01], and liver-related mortality [HR 3.24 (95%CI:1.18–8.94), p=0.02]. Conclusion Hepatitis C virus infection is independently associated with all-cause and liver-related mortality in human immunodeficiency virus-infected patients with alcohol problems, even when accounting for alcohol and other drug use.

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“…Previous research has indicated that a large portion of the unspecified cirrhosis deaths were in fact alcohol-related (Parrish et al, 1993). Moreover, the detection of HCV has not been comprehensive for various reasons (Manos et al, 2008; Wu et al, 2005). Third, data from death certificates lack information on etiological factors other than alcohol and HCV.…”

Section: Discussionmentioning

confidence: 99%

Alcohol-Related and Viral Hepatitis C-Related Cirrhosis Mortality among Hispanic Subgroups in the United States, 2000-2004

Yoon¹,

Yi²,

Thomson

2010

Alcoholism: Clinical and Experimental Research

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Background-Hispanics have much higher cirrhosis mortality rates than non-Hispanic Blacks and Whites. Although heavy alcohol use and hepatitis C virus (HCV) infection are two major risk factors for cirrhosis, no studies have systematically assessed the contribution of alcohol-and HCV-related cirrhosis deaths to the total cirrhosis mortality for Hispanics as a whole and its variations across Hispanic subgroups. To fill this gap, the current study presents the latest data on total cirrhosis mortality as well as its component alcohol-and HCV-related cirrhosis mortality for all Hispanics and for Hispanic subgroups.

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Estimating the mortality rate of hepatitis C using multiple data sources

Cited by 18 publications

References 14 publications

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Chronic hepatitis C virus infection is associated with all‐cause and liver‐related mortality in a cohort of HIV‐infected patients with alcohol problems

Alcohol-Related and Viral Hepatitis C-Related Cirrhosis Mortality among Hispanic Subgroups in the United States, 2000-2004

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