Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Marcellin, Patrick; Péquignot, F; Delarocque-Astagneau, Elisabeth; Zarski, Jean–Pierre; Ganne, Nathalie; Hillon, Patrick; Antona, Denise; Bovet, M.; Mechain, Murielle; Asselah, Tarik; Desenclos, Jean‐Claude; Jougla, Éric

doi:10.1016/j.jhep.2007.09.010

Cited by 139 publications

(103 citation statements)

References 31 publications

(34 reference statements)

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“…Moreover, alcohol abuse in patients with chronic hepatitis B is associated with increased risk of cirrhosis and HCC (Corrao et al, 1998;Larkin et al, 2001). Marcellin et al (2008) found a strong association between alcohol consumption and mortality in these patients.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20 g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P ! .001) were observed in the group with alcohol intake above 20 g/day, as well a lower proportion of patients with HBeAg negativity (P #.035). In this group, biochemistry parameters, such as alanine aminotransferase (P 5 .006), aspartate aminotransferase (P 5 .001), gamma-glutamyl transferase (P ! .001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P 5 .042) and mean corpuscular volume (P ! .001) and significantly higher values of prothrombin time (P ! .001) in the group with higher levels of alcohol consumption. The characteristics of biopsy (P ! .001) and ChildePhug's classification (P 5 .002) revealed more severe results in this group. Logistic regression showed a positive association between liver damage and alcohol intake, increasing with age. In female patients, a strong positive association between alcohol intake and liver damage was also found (odds ratio: 9.379; 95% confidence interval: 0.859e468.422; P 5 .037); however, the most severe cases were only observed in women older than 45 years. In patients with HBV infection, alcohol is associated with a more severe liver disease. No evidence was found concerning association with HBV genotype. Ó

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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“…Reducing alcohol intake can restrict the severity of liver injury in those with other liver disorders (Ostapowicz et al 1998(Ostapowicz et al , 2001Marcellin et al 2008).…”

Section: Liver Diseases Of Any Form -mentioning

confidence: 99%

Survey of alcohol-related presentations to Australasian emergency departments

et al. 2014

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Objective: To determine the proportion of alcohol‐related presentations to emergency departments (EDs) in Australia and New Zealand, at a single time point on a weekend night shift. Design, setting and participants: A point prevalence survey of ED patients either waiting to be seen or currently being seen conducted at 02:00 local time on 14 December 2013 in 106 EDs in Australia and New Zealand. Main outcome measures: The number of ED presentations that were alcohol‐related, defined using World Health Organization ICD‐10 codes. Results: At the 106 hospitals (92 Australia, 14 New Zealand) that provided data, 395 (14.3%; 95% CI, 13.0%–15.6%) of 2766 patients in EDs at the study time were presenting for alcohol‐related reasons; 13.8% (95% CI, 12.5%–15.2%) in Australia and 17.9% (95% CI, 13.9%–22.8%) in New Zealand. The distribution was skewed left, with proportions ranging from 0 to 50% and a median of 12.5%. Nine Australian hospitals and one New Zealand hospital reported that more than a third of their ED patients had alcohol‐related presentations; the Northern Territory (38.1%) and Western Australia (21.1%) reported the highest proportions of alcohol‐related presentations. Conclusions: One in seven ED presentations in Australian and New Zealand at this 02:00 snapshot were alcohol‐related, with some EDs seeing more than one in three alcohol‐related presentations. This confirms that alcohol‐related presentations to EDs are currently underreported and makes a strong case for public health initiatives.

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“…Several epidemiological studies have shown that seropositivity for HBsAg is an important risk factor for liver disease, including cirrhosis and HCC (21)(22)(23)(24).…”

Section: Hbsag: Clinical Relevancementioning

confidence: 99%

Quantification of hepatitis B surface antigen: a new concept for the management of chronic hepatitis B

Moucari

Marcellin

2011

Liver International

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HBsAg is a very important clinical test that might not only indicate active hepatitis B virus (HBV) infection but might also be used to predict clinical and treatment outcome. Clearance of HBsAg in patients with chronic HBV infection is associated with a much better clinical outcome, although surveillance for early detection of hepatocellular carcinoma (HCC) should continue. HBV DNA quantification is currently used for selecting candidates for therapy, monitoring response to therapy and detecting the emergence of drug resistance. Assays for HBsAg quantification are less expensive than HBV DNA and fully automated with a high throughput capacity. HBsAg titering may be a useful tool to manage patients with chronic HBV, to more clearly define which patients may, and more importantly, may not, benefit from treatment. Baseline and on-treatment HBsAg quantification may help to refine future treatment algorithms for both immune-modulator therapy and nucleos(t)ide analogues. Both HBV markers provide complementary information on the status of HBV infection. However, the relevance of serum HBsAg levels and its use as a reliable replacement for both covalently closed circular DNA and HBV DNA remain unclear.

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Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

Cited by 139 publications

References 31 publications

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Survey of alcohol-related presentations to Australasian emergency departments

Quantification of hepatitis B surface antigen: a new concept for the management of chronic hepatitis B

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