Estimating the Incidence and Prevalence of Juvenile-Onset Recurrent Respiratory Papillomatosis in Publicly and Privately Insured Claims Databases in the United States

Abstract

Although relatively uncommon, JORRP represents a disease with significant morbidity. The incidence and prevalence of JORRP in publicly insured children were consistently higher than those covered by private insurance plans, suggesting an increased burden of illness among those with lower socioeconomic status.

The incidence and prevalence of juvenile-onset recurrent respiratory papillomatosis in the Free State province of South Africa and Lesotho

“…Patients with small papillomas not requiring surgery would therefore not have been included even though they have active disease and would thus result in the true prevalence being underestimated. However this method of calculating the prevalence of JORRP was used in other studies on the prevalence of JORRP and was thus also used in this study in order to make comparison with those studies possible [3,[7][8][9][10].…”

“…JORRP is associated with lower socioeconomic status [8]. The Free State and Lesotho both have a high rate of poverty, with the Free State having a poverty rate of 41.2% and Lesotho a poverty rate of 43.2% [21,22].…”

“…The infection is believed to be acquired from the mother's genital tract during the birthing process [1]. Although the estimated incidence and prevalence of JORRP has been determined in countries in North America and Europe and in Australia [2][3][4][5][6][7][8][9][10], there have not been any studies that have attempted to determine the incidence or prevalence of JORRP in African countries.…”

Juvenile recurrent respiratory papillomatosis: 10‐year audit and Australian prevalence estimates

“…The rarity of the disease, and its variable course, has made studying the disease and the efficacy of potential treatment strategies challenging. Prevalence estimates range from <1 to 4 per 100,000 . Typically, patients require multiple treatments over years to maintain airway and voice, although this is highly variable, with most requiring less frequent surgery over time …”

Quality of life of young patients with recurrent respiratory papillomatosis

“…1 The condition is usually caused by human papillomavirus (HPV) types 6 and 11; patients infected by HPV type 11 are prone to develop more aggressive disease. In the USA, the prevalence estimates are 0.51-1.03 per 100 000 children.…”