Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

Erlandsen, Erland J.; Hansen, Rikke Middelhede; Randers, Else; Petersen, Lise; Abrahamsen, Jan; Johannesen, Inger Lauge

doi:10.1038/sc.2012.52

Cited by 31 publications

(25 citation statements)

References 17 publications

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“…10,11,18 It is produced by most nucleated cells at a stable rate and is, most importantly, not affected by the level of muscle mass, gender or age, 10 which makes it a promising test in this patient population and hence it should probably substitute p-creatinine in the future. …”

Section: Discussionmentioning

confidence: 99%

“…Only three of the papers used the gold standards 51 Cr-EDTA clearance 10,11 or 99m Tc-DTPA clearance. 2 They all concluded that s-creatinine underestimated the renal deterioration, except for one study, Sepahpanah et al, 17 which concluded that s-creatinine was better in monitoring renal function than creatinine clearance.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only three studies have investigated the relationship between p-creatinine and renal function monitored by 51 Cr-EDTA or 99m Tc-DTPA clearance, which is considered the gold standard. 2,10,11 Of these three studies, none of them investigated p-creatinine over time and two of them only comprised 31 and 36 patients, respectively.…”

Section: Introductionmentioning

confidence: 99%

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50 years follow-up on plasma creatinine levels after spinal cord injury

2014

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Study design: Retrospective chart review. Objectives: To investigate the role of plasma creatinine (p-creatinine) in monitoring renal deterioration in patients up to 50 years after spinal cord injury (SCI). Setting: The Clinic for Spinal Cord Injuries, Rigshospitalet, Denmark. Methods: A total of 119 patients with a traumatic SCI during the years were included in the study. P-creatinine measurements, results from renography and glomerular filtration rate (GFR) measured with 51 Cr-EDTA clearance were obtained from medical records and analyzed using a linear mixed model and linear regression analyses. Results: When compared with median p-creatinine level in the first 5-year period after injury, the level of p-creatinine was stable throughout the first 30 years and decreased significantly after the 30th until 45th year post injury. Only patients with a functional distribution outside the 30-70% limits on renography or a relative GFR p51% of that expected had a significantly elevated level of p-creatinine. Significance was not found for patients with a distribution outside the 40-60% limits on renography or relative GFR p75%. By comparing Cr-EDTA clearance and p-creatinine in terms of exceeding the upper reference level, p-creatinine revealed 17% sensitivity, 100% specificity, 100% positive predictive value and 73% negative predictive value as a diagnostic test for renal deterioration defined as GFR p75%. Conclusion: P-creatinine decreases over time in patients with SCI with a level below the upper reference limit and is a poor detector of early renal deterioration in patients with SCI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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50 years follow-up on plasma creatinine levels after spinal cord injury

2014

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“…Previous studies have shown that serum CysC levels could detect the early decrease of renal function and correlated better with 50 Cr EDTA clearance than sCr in the general population . Although only a few studies have tested the usefulness of CysC as a surrogate marker of renal function in the NB population, the authors showed that CysC is more correlated with 51 Cr‐EDTA‐clearance or inulin clearance than sCr or sCr‐based eGFR . Recently, Mingat et al reported that the CysC‐based eGFR by CKD‐EPI equation was the most precise method in NB patients with various neurologic disorders, whether ambulatory or wheelchair …”

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confidence: 99%

Chronic kidney disease in neurogenic bladder

Sung¹,

Choi³

et al. 2018

Nephrology

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“…The panel recommends a cystatin C test for early detection of renal impairment, because cystatin C is less affected by muscle mass than creatinine ( LoE 5, GoR C1 ) …”

Section: Summary Of the Guidelinesmentioning

confidence: 99%

Clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury

et al. 2020

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The present article is an abridged English translation of the Japanese clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury updated as of July 2019. The patients are adult spinal cord injured patients with lower urinary tract dysfunction; special consideration of pediatric and elderly populations is presented separately. The target audience is healthcare providers who are engaged in the medical care of patients with spinal cord injury. The mandatory assessment includes medical history, physical examination, frequency‐volume chart, urinalysis, blood chemistry, transabdominal ultrasonography, measurement of post‐void residual urine, uroflowmetry and video‐urodynamic study. Optional assessments include questionnaires on the quality of life, renal scintigraphy and cystourethroscopy. The presence or absence of risk factors for renal damage and symptomatic urinary tract infection affects urinary management, as well as pharmacological treatments. Further treatment is recommended if the maximum conservative treatment fails to improve or prevent renal damage and symptomatic urinary tract infection. In addition, management of urinary incontinence should be considered individually in patients with risk factors for urinary incontinence and decreased quality of life.

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Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

Abstract: In patients with SCI, GFR can be estimated independent of age, sex and muscle mass by a newly developed equation based on a single serum CysC value.

Cited by 31 publications

References 17 publications

50 years follow-up on plasma creatinine levels after spinal cord injury

50 years follow-up on plasma creatinine levels after spinal cord injury

Chronic kidney disease in neurogenic bladder

Clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury

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