Estimating the burden of disease and the economic cost attributable to chikungunya, Colombia, 2014

Cardona-Ospina, Jaime A.; Villamil-Gómez, Wilmer E.; Jiménez-Cañizales, Carlos Eduardo; Castañeda-Hernández, Diana M.; Rodríguez‐Morales, Alfonso J.

doi:10.1093/trstmh/trv094

Cited by 84 publications

(73 citation statements)

References 24 publications

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“…CHIK is self-limiting and has a low mortality rate; however, fatal infections and chronic rheumatic disorders do occur (Charrel, De Lamballerie & Raoult, 2007). The infection not only poses adverse impact on human health but also contributes to overall socioeconomic burden of the community and health care system (Cardona-Ospina, Villamil-Gómez & Jimenez-Canizales, 2015). The virus can establish itself in any tropical or temperate region harboring the Aedes mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey

Mallhi

Khan

Tanveer

et al. 2018

PeerJ

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BackgroundThe World Health Organization (WHO) declares Chikungunya (CHIK) infection to be endemic in South Asia. Despite its first outbreak in Pakistan, no documented evidence exists which reveals the knowledge or awareness of healthcare students and workers (HCSW) regarding CHIK, its spread, symptoms, treatment and prevention. Since CHIK is an emergent infection in Pakistan, poor disease knowledge may result in a significant delay in diagnosis and treatment. The current study was aimed to evaluate the awareness and knowledge of CHIK among HCSW.MethodsA cross-sectional study was conducted among HCSW from teaching institutes and hospitals in seven provinces of Pakistan. We collected information on socio-demographic characteristics of the participants and their knowledge by using a 30-item questionnaire. The cumulative knowledge score (CKS) was calculated by correct answers with maximum score of 22. The relationship between demographics and knowledge score was evaluated by using appropriate statistical methods.ResultsThere were 563 respondents; mean age 25.2 ± 5.9 years with female preponderance (62.5%). Of these, 319 (56.7%) were aware of CHIK infection before administering the survey. The average knowledge score was 12.8 ± 4.1 (% knowledge score: 58.2%). Only 31% respondents had good disease knowledge while others had fair (36.4%) and poor (32.6%) knowledge. Out of five knowledge domains, domain III (vector, disease spread and transmission) and V (prevention and treatment) scored lowest among all i.e. percent score 44.5% and 54.1%, respectively. We found that socio-demographic characteristics had no influence on knowledge score of the study participants.ConclusionApproximately one-half of participants were not aware of CHIK infection and those who were aware had insufficient disease knowledge. Findings of the current study underscore the dire need of educational interventions not only for health care workers but also for students, irrespective to the discipline of study.

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Section: Introductionmentioning

confidence: 99%

Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey

Mallhi

Khan

Tanveer

et al. 2018

PeerJ

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“…This human migration is associated with other infectious diseases, such as malaria or measles [8]. The burden that will be imposed on the region, if and when COVID-19 spreads, would be an additional challenge for the healthcare systems and economies in the region, as we faced with Zika and even the Chikungunya outbreaks [9]. For example, there is concern about the availability of intensive care units, that are necessary for at least 20-25% of patients hospitalized with COVID-19-also, the availability of specific diagnostic tests, particularly the real-time RT-PCR is a crucial challenge for early detection of COVID-19 importation and prevention of onward transmission.…”

mentioning

confidence: 99%

COVID-19 in Latin America: The implications of the first confirmed case in Brazil

Rodríguez‐Morales

Gallego²,

Escalera-Antezana³

et al. 2020

Travel Medicine and Infectious Disease

458

362

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“…In Colombia, cases of CHIKV infection were first identified in July 2014 (Cardona-Ospina et al , 2015) followed by cases of ZIKV infection in October 2015 (Pacheco et al , 2016). Both viruses cause similar initial symptoms with some distinctions, but a key difference between them is the short time course of ZIKV infection of two weeks or less, whereas infection with CHIKV can lead to arthritis and arthralgias that may persist for a year or more.…”

Section: Introductionmentioning

confidence: 99%

Zika and Chikungunya virus co-infection in a traveller returning from Colombia, 2016: virus isolation and genetic analysis

et al. 2016

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Introduction:Zika virus (ZIKV) and Chikungunya virus (CHIKV) can share the same mosquito vector, and co-infections by these viruses can occur in humans. While infections with these viruses share commonalities, CHIKV is unique in causing arthritis and arthralgias that may persist for a year or more. These infections are commonly diagnosed by RT–PCR-based methods during the acute phase of infection. Even with the high specificity and sensitivity characteristic of PCR, false negatives can occur, highlighting the need for additional diagnostic methods for confirmation.Case presentation:On her return to the USA, a traveller to Colombia, South America developed an illness consistent with Zika, Chikungunya and/or Dengue. RT-PCR of her samples was positive only for ZIKV. However, arthralgias persisted for months, raising concerns about co-infection with CHIKV or Mayaro viruses. Cell cultures inoculated with her original clinical samples demonstrated two types of cytopathic effects, and both ZIKV and CHIKV were identified in the supernatants. On phylogenetic analyses, both viruses were found to be related to strains found in Colombia.Conclusion:These findings highlight the need to consider CHIKV co-infection in patients with prolonged rheumatological symptoms after diagnosis with ZIKV, and the usefulness of cell culture as an amplification step for low-viremia blood and other samples.

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Estimating the burden of disease and the economic cost attributable to chikungunya, Colombia, 2014

Cited by 84 publications

References 24 publications

Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey

Awareness and knowledge of Chikungunya infection following its outbreak in Pakistan among health care students and professionals: a nationwide survey

COVID-19 in Latin America: The implications of the first confirmed case in Brazil

Zika and Chikungunya virus co-infection in a traveller returning from Colombia, 2016: virus isolation and genetic analysis

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