Estimating retinal nerve fiber layer thickness in normal schoolchildren with spectral-domain optical coherence tomography

Tsai, Der‐Chong; Huang, Nicole; Hwu, Jinn Jong; Jueng, Ruo Nan; Chou, Pesus

doi:10.1007/s10384-012-0142-7

Cited by 51 publications

(64 citation statements)

References 31 publications

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“…We found that the mean total RNFL thickness was 105 μ m ± 10.3, which is comparable to data obtained from previous studies [5, 12, 13, 15–17] and slightly higher compared to another group of studies using mainly the Cirrus OCT [6, 9, 18, 19]. It is possible that this discrepancy is due to segmentation differences in the definition of the outer border of RNFL and optical interaction with tissue due to different light sources and laser camera system sensor between Cirrus and Topcon OCT [20].…”

Section: Discussionsupporting

confidence: 90%

Retinal Fibre Layer Thickness Measurement in Normal Paediatric Population in Sweden Using Optical Coherence Tomography

Ayala

Ntoula

2016

Journal of Ophthalmology

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Purpose. To evaluate the correlation between peripapillary retinal nerve fibre layer (RNFL) thickness and both age and refraction error in healthy children using optical coherence tomography (OCT). Patients and Methods. 80 healthy children with a mean age of 9.1 years (range 3.8 to 16.7 years) undergoing routine ocular examination at the orthoptic section of the Ophthalmology Department were recruited for this cross-sectional study. After applying cycloplegia, the peripapillary RNFL thickness was measured in both eyes using the Topcon 3D OCT 2000 device. Results. 138 eyes were included in the analysis. The average refractive error (SE) was +1.7 D (range −5.25 to +7.25 D). The mean total RNFL thickness was 105 μm ± 10.3, the mean superior RNFL thickness was 112.7 μm ± 16.5, and the mean inferior RNFL thickness was 132.6 μm ± 18.3. We found no statistically significant effect of age on RNFL thickness (ANOVA, f = 0.33, p = 0.56). Refraction was proven to have a statistically significant effect (ANOVA, f = 67.1, p < 0.05) in RNFL measurements. Conclusions. Data obtained from this study may assist in establishing a normative database for a paediatric population. Refraction error should be taken into consideration due to its statistically significant correlation with RNFL thickness.

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Section: Discussionsupporting

confidence: 90%

Retinal Fibre Layer Thickness Measurement in Normal Paediatric Population in Sweden Using Optical Coherence Tomography

Ayala

Ntoula

2016

Journal of Ophthalmology

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“…Temporal, inferior and nasal outer circle thicknesses (A7, A8, A9) 11 In our study, quadrant thickness distribution of RNFL followed the "ISNT" rule. 12 Chen and Tsai's results differed from ours as they followed SITN and ISTN sequences respectively.…”

Section: Resultssupporting

confidence: 54%

“…12 Chen and Tsai's results differed from ours as they followed SITN and ISTN sequences respectively. 10,11 In all previous SD-OCT studies that have reported RNFL thickness in children, the superior and inferior quadrants were found to be thicker than the nasal and temporal quadrants, congruent with the "double-hump" pattern. 1,[3][4][5][6]10,11,13,14 It has been reported in most studies that RNFL thickness decreases with myopia and increases with hyperopia.…”

Section: Resultsmentioning

confidence: 69%

“…15,16 However, in most paediatric studies including ours, age was not found to effect RNFL thickness. [1][2][3][4][5][6]11,14 It has been suggested in some adult studies that age-related thinning of RNFL starts later in life and the rate of loss is slower in younger ages. 17,18 This may explain the lack of an independent correlation between RNFL thickness and age among children.…”

Section: Resultsmentioning

confidence: 99%

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Retinal Nerve Fiber Layer and Macula Thickness with Spectral Domain Optical Coherence Tomography in Children: Normal Values, Repeatability and the Inflfluence of Demographic and Ocular Parameters

Kızıloğlu¹,

Toygar²,

Toygar³

et al. 2018

Turkiye Klinikleri J Ophthalmol

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine normal values for retinal nerve fiber layer (RNFL) and macular thickness in children using spectral domain optical coherence tomography (SD-OCT), to assess the repeatability of the SD-OCT measurements and to analyse their correlations with age, gender, refraction and axial length. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Healthy children aged 5-17 years were enrolled for this cross-sectional study. All subjects underwent comprehensive ophthalmological examination, cycloplegic refraction and axial length measurement. Thereafter, three consecutive SD-OCT measurements were obtained by the same operator. The mean of three consecutive measurements for each SD-OCT parameter was included in the normal values. Repeatability was calculated by comparing the three consecutive measurements and expressed as an intraclass correlation coefficient. The correlation of all SD-OCT parameters with age, gender, spherical equivalent refraction and axial length were statistically analysed. R Re es su ul lt ts s: : Two hundred two eyes of 202 children (103 females and 99 males) with a mean age of 10.4±3.4 years were included. The mean of average RNFL thickness was 103.9±8.2 (84.3-132) µm. The mean central macular thickness was 257.4± 22.1 (217-329) µm. Intraclass correlation coefficients of repeated measurements were over 0.81 for all evaluated parameters. Males had significantly thicker central macula than females (p=0.013). On multivariate linear regression analysis, spherical equivalent refraction was the only parameter independently effective on average RNFL thickness (p<0.001). C Co on nc cl lu us si io on n: : This study has provided normal values for RNFL and macular thickness measured with SD-OCT in healthy children. The high repeatability of the measurements indicates that SD-OCT can be used reliably in children that are five years and older. Data obtained in this study may be helpful in the assessment of childhood optic nerve and macular diseases with SD-OCT. K Ke ey yw wo or rd ds s: : Child; tomography, optical coherence; macula lutea; retina Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda spektral domain optik koherens tomografi (SD-OKT) ile retina sinir lifi (RSLT) ve maküla kalınlıklarının normal değerlerini belirlemek, SD-OKT ölçümlerinin tekrarlanabilirliğini ve yaş, cinsiyet, refraksiyon ve aksiyel uzunluk ile ilişkilerini saptamak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu kesitsel çal-ışmaya yaşları 5-17 yıl arasında değişen sağlıklı çocuklar dahil edildi. Tüm olguların ayrıntılı göz muayenesi, sikloplejik refraksiyon ve aksiyel uzunluk ölçümleri yapıldı. Sonrasında art arda üç kez aynı görevli tarafından SD-OKT ölçümleri alındı. Normal değerler belirlenirken her parametre için bu üç ölçümün ortalaması alındı. Tekrarlanabilirlik ise bu üç ölçüm karşılaştırılarak hesaplandı ve sınıf içi korelasyon katsayısı olarak ifade edildi. Ayrıca tüm SD-OKT parametrelerinin yaş, cinsiyet, sferik ekivalan refraksiyon ve aksiyel uzunluk...

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“…In the present study, we included such patients, and the difference in cpRNFL thickness between the two eyes was found to be significantly related to the difference in axial length and refractive error. Tsai et al35 demonstrated that the spherical equivalent refraction is a significant predictor of the pediatric RNFL thickness. However, Wang et al36 reported that the effects of magnification attributable to the axial length and refractive error on the measurement of the RNFL thickness were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki¹,

Miki²,

Yamashita³

et al. 2014

OPTH

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PurposeTo compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.Patients and methodsA total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).ResultsThe amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.ConclusionWe found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

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Estimating retinal nerve fiber layer thickness in normal schoolchildren with spectral-domain optical coherence tomography

Abstract: Our study provides reference values of pediatric RNFL thickness measured with SD-OCT. SE refraction is the only significant predictor of RNFL thickness.

Cited by 51 publications

References 31 publications

Retinal Fibre Layer Thickness Measurement in Normal Paediatric Population in Sweden Using Optical Coherence Tomography

Retinal Fibre Layer Thickness Measurement in Normal Paediatric Population in Sweden Using Optical Coherence Tomography

Retinal Nerve Fiber Layer and Macula Thickness with Spectral Domain Optical Coherence Tomography in Children: Normal Values, Repeatability and the Inflfluence of Demographic and Ocular Parameters

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

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