Estimating health utilities in patients with asthma and COPD: evidence on the performance of EQ-5D and SF-6D

Szende, Ágota; Leidy, NK; Ståhl, Elisabeth; Svensson, Kristoffer

doi:10.1007/s11136-008-9429-z

Cited by 51 publications

(48 citation statements)

References 31 publications

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“…Különböző betegségekben végzett hazai keresztmetszeti kérdőíves vizsgálatokban többször alkalmazásra került az EQ-5D kérdőív a betegek egészségi állapotának felmérésére, mint például a psoriasis [3,4,5,6], rheumatoid arthritis [7,8,9,10], jóindulatú prosztatamegnagyobbodás [11], epilepszia [12], perifériás artériás obliteratív érbetegség [13], sclerosis multiplex [14], hiperaktív hólyag szindróma [15], szkizofrénia [16], kró-nikus obstruktív tüdőbetegség (COPD) [17,18], demencia [19], Parkinson-kór [20,21,22], arthritis psoriatica [5,23], asztma [17,24] és 2-es típusú cukorbetegség [25] esetében.…”

Section: Rövidítésekunclassified

A magyar lakosság egészségi állapota 2000 és 2010 között

et al. 2015

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Pécsi Tudományegyetem, Egészségbiztosítási Intézet, Pécs 5 Pest Megyei Flór Ferenc Kórház, Reumatológiai és Fizioterápiás Osztály, KistarcsaBevezetés: Hazánkban 2000-ben készült olyan felmérés, amely a lakosság egészségi állapotát vizsgálta EQ-5D kérdő-ívvel. Célkitűzés: A lakosság egészségi állapotának felmérése különböző szociodemográfi ai jellemzők szerint és össze-hasonlítás a 2000-es adatokkal. Módszer: 2010-ben egy nemzetközi kutatás keretében internetalapú keresztmetszeti kérdőíves vizsgálatot végeztek a lakosság körében az EQ-5D-3L kérdőívvel. Eredmények: 2281 válaszadó (nők: 62,3%) töltötte ki a kérdőívet, az átlagéletkor 40,8 év volt. Az EQ-5D-index 0,902 (18-24 év) és 0,795 (65+) között alakult. Szignifi káns összefüggést találtak az életminőség és a nem, életkor, iskolázottság, jövedelem között (F( 4,1967 ) = 35,12, p = 0,000). Az eredmények nem térnek el szignifi kánsan a 2000-es felmérés eredményeitől a 18-24 éves korcsoportot kivéve, ahol alacsonyabb értékeket kaptak. Következtetések: Miközben 2000 és 2010 között a lakosság várható élettartama 3 évvel nőtt, az egészségi állapota nem javult, sőt a 18-24 év közötti korosztályban romolhatott is, nemzetközi összehasonlításban pedig továbbra is a legrosszabbak közé tartozik. Nem csökkentek az egészségi ál-lapottal összefüggő egyenlőtlenségek jövedelem és iskolai végzettség szerint. Orv. Hetil., 2015Hetil., , 156(50), 2035Hetil., -2044 Kulcsszavak: egészségi állapot, EQ-5D, EuroVaQ, Magyarország Health state of the Hungarian population between 2000-2010Introduction: So far, the latest survey which used the EQ-5D questionnaire to measure the health status of the Hungarian population was carried out in 2000. Aim: To explore the health state of the Hungarian population by sociodemographic characteristics, and to compare it with the results from 2000. Method: As part of an international research project, a cross-sectional, online survey was carried out among the general population in 2010 using the EQ-5D-3L questionnaire. Results: In total, 2281 respondents (female: 62.3%) completed the questionnaire with an average age of 40.8 years. The EQ-5D score ranged from 0.902 (in age-group 18-24) to 0.795 (65+). The authors found signifi cant association between the EQ-5D score and all the socio-demographic variables (gender, age, education, income) included in the regression model (F( 4,1967 ) = 35.12, p = 0.000). The results did not differ signifi cantly from the health survey in 2000, except for the youngest population group (age 18-24), where signifi cantly lower scores were found in the sample. Conclusions: While life expectance increased by 3 years between 2000 and 2010, the health status of the Hungarian population did not change signifi cantly, and might even decreased among young adults in fact. Inequalities in health status by income and education remain signifi cant. In international comparison, the health status of the Hungarian population remains among the worst ones.

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Section: Rövidítésekunclassified

A magyar lakosság egészségi állapota 2000 és 2010 között

et al. 2015

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“…Instruments that can differentiate between groups or severity levels with statistical Szende et al, [33] Hungary, Sweden significance or by pre-determined clinically important differences are more likely to reflect differences in HR-QOL when there are distinctions. Studies that include MAU measures have reported utilities based on COPD severity level diagnosed, mostly categorized based on the GOLD classification using FEV 1 .…”

Section: Stable Chronic Obstructive Pulmonary Disease (Copd) Severitymentioning

confidence: 99%

Utility Estimation in Chronic Obstructive Pulmonary Disease

et al. 2011

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Economic evaluations of chronic obstructive pulmonary disease (COPD) incorporate utilities through multi-attribute utility (MAU) measures, most commonly the EQ-5D, to report health-related quality-of-life (HR-QOL) changes or differences. Questions have been raised about the sensitivity of these measures in COPD. Limitations in detecting adequate patient-level changes in HR-QOL over time in stable and exacerbation states compared with disease-specific instruments could also result in underestimation of known treatment benefits. The purpose of this article was to present and discuss the empirical evidence on the validity of generic MAU measures within the COPD population. We built upon a previously conducted validation review for the period 1997-2007 that used 'respiratory disease' and 'EQ-5D' as keywords. For this discussion, PubMed and EMBASE databases were searched for articles in English from 1988 to August 2009, using similar search words. Based on the performance of MAU measures in COPD and exacerbations, they appear to have limited discriminatory ability, particularly between moderate and severe COPD, despite known differences in HR-QOL. Sensitivity to clinically relevant change in stable COPD over time due to treatment also appears limited. Current research suggests adequate sensitivity regarding detecting the onset and resolution of an exacerbation; however, sensitivity is limited in the short term, such as daily changes in health status. The evidence suggests responsiveness of MAU measures may be restricted to large within-patient change, which leads to difficulties in evaluating the subtle but important impact of exacerbations. Studies presenting alternative methods of deriving COPD-related utilities are also discussed. Overall, the insensitivities of generic MAU measures in COPD can lead to biased cost-effectiveness analyses and ill-informed economic decisions. Alternative measures such as condition-specific preference-based measures may be used in circumstances where more sensitivity is needed. The trade-off allows relevant and sensitive matters most important to patients to be evaluated; however inevitable gaps such as those related to adverse events are not considered.

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“…32,37,39 Few studies have been devoted to the comparison of the EQ-5D and the SF-6D in the general population, 45,58 along with the comparison of their performances for more than one disease. 35,59 The pattern of findings of most of these studies is that the EQ-5D tends to generate higher utility values than the SF-6D in groups with better states of health, whilst the opposite usually occurs in groups with worse health states. Furthermore, the conclusions of these studies have indicated a ceiling effect in the EQ-5D and a floor effect in the SF-6D, especially in patients with more serious illnesses.…”

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confidence: 99%

Comparing the Performance of the SF-6D and the EQ-5D in Different Patient Groups

Ferreira

Pereira

2014

Acta Med Port

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RESUMOIntrodução: O objectivo geral deste artigo consiste em comparar o desempenho do EQ-5D e do SF-6D em quatro grupos de doentes que sofrem de asma, doença pulmonar obstrutiva crónica, cataratas e artrite reumatóide. Em particular, este artigo tem dois objectivos específicos: 1) estudar o nível de concordância entre os índices e os sistemas descritivos das dimensões do SF-6D e EQ-5D, e 2) analisar a capacidade de discriminação dos instrumentos. Material e Métodos: Uma amostra de 643 doentes respondeu ao SF-36v2 e ao EQ-5D. Foram analisados a capacidade de discriminação dos instrumentos, bem como o nível de concordância entre os índices e os sistemas descritivos das dimensões do SF-6D e EQ-5D. O nível de concordância entre os instrumentos foi estudado com base em coeficientes de correlação e nos gráficos de BlandAltman, enquanto a influência da condição médica e de outras variáveis de natureza sociodemográfica nos índices foi analisada com o recurso a testes não paramétricos. Utilizaram-se também testes para amostras emparelhadas para identificar diferenças entre os scores finais dos instrumentos. Resultados e Discussão: Verificou-se a existência de uma correlação forte e de uma concordância elevada entre os dois índices. Em termos globais, os índices diferem por condição médica e por grupo sociodemográfico e ambos os instrumentos demonstraram uma capacidade discriminativa semelhante entre grupos sociodemográficos Conclusão: Confirmou-se a hipótese de que o SF-6D gera valores de utilidade superiores em populações com doenças. O SF-6D e o EQ-5D parecem comportar-se de forma diferente em cada uma das doenças analisadas, uma vez que as medidas descritivas diferem entre instrumentos e os coeficientes de correlação não são uniformes. Os resultados demonstraram que o EQ-5D e o SF-6D geram valores de utilidade diferentes, mas que existe uma concordância elevada entre os dois instrumentos. Pode-se concluir que os resultados dos instrumentos não são directamente comparáveis. Palavras-chave: Questionários; Qualidade de Vida; Indicadores Básicos de Saúde; Portugal. ABSTRACT Introduction:This research aims to explore the performance of the SF-6D and the EQ-5D in patients suffering from asthma, chronic obstructive pulmonary disease, cataracts, and rheumatoid arthritis. In particular, the aim of this research is twofold: 1) to study the level of agreement between the indexes and the descriptive systems of the dimensions of the SF-6D and the EQ-5D, and 2) to analyze the discriminative ability of the instruments. Material and Methods: A sample of 643 patients completed both the SF-36v2 and the EQ-5D. The discriminative ability of the instruments was analyzed. Furthermore, the level of agreement between the indexes and the descriptive systems of the dimensions of the SF-6D and the EQ-5D were studied. The level of agreement between instruments was investigated using correlation coefficients and the Bland-Altman plots, while the influence of medical condition and other socio-demographic variables was analyzed using nonparametric ...

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Estimating health utilities in patients with asthma and COPD: evidence on the performance of EQ-5D and SF-6D

Abstract: Results suggest the EQ-5D and SF-6D do not yield consistent utility values in patients with asthma and COPD due to differences in underlying valuation techniques and the EQ-5D's limited response options relative to mild disease.

Cited by 51 publications

References 31 publications

A magyar lakosság egészségi állapota 2000 és 2010 között

A magyar lakosság egészségi állapota 2000 és 2010 között

Utility Estimation in Chronic Obstructive Pulmonary Disease

Comparing the Performance of the SF-6D and the EQ-5D in Different Patient Groups

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