Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods

MacIsaac, Richard J; Tsalamandris, Con; Thomas, Merlin C.; Premaratne, Erosha; Panagiotopoulos, Sianna; Smith, T. K.; Poon, Aurora; Jenkins, Margaret A.; Ratnaike, Sujiva; Power, David A.; Jerums, George

doi:10.1007/s00125-006-0275-7

Cited by 152 publications

(148 citation statements)

References 10 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…In a recent comparison of rates of decline of GFR in type 1 diabetes at our centre, serial estimates of GFR decline by creatinine-based methods in patients with an initial isotopically measured GFR of 106±2.6 ml min −1 1.73 m −2 underestimated the GFR gradient measured isotopically by over 50% during a follow-up of 10 years [73]. In contrast, we and others have shown that cystatin Cbased methods for estimating GFR accurately reflect reference GFR measurements in the normal to high range [73][74][75][76].…”

Section: Resolution Of Hyperfiltration In Clinical Trialsmentioning

confidence: 56%

The clinical significance of hyperfiltration in diabetes

et al. 2010

Self Cite

View full text Add to dashboard Cite

Glomerular filtration rate is commonly elevated in early diabetes and patients with this symptom are arbitrarily considered to have hyperfiltration. The prevalence of hyperfiltration in type 1 diabetes varies from less than 25% to more than 75%. The corresponding figures in type 2 diabetes are significantly lower, ranging between 0% and more than 40%. Several factors, methodological and biological, may contribute to the wide variation in estimates of hyperfiltration prevalence. Methodological differences in measurement and evaluation of GFR apply in particular to the handling of plasma disappearance curves of filtration markers. Biological factors that may influence GFR in the hyperfiltration range include glycaemic control, diabetes duration, BMI, sex, pubertal status in type 1 diabetes and age in type 2 diabetes. Hyperglycaemia may influence GFR and albuminuria, and may therefore confound the evaluation of hyperfiltration as an independent risk factor for diabetic nephropathy. Adequate assessment of the relationship between glycaemic control, GFR and AER therefore requires serial measurements of all three variables followed by multivariate analysis. A recent meta-analysis of ten type 1 diabetes studies concluded that the presence of hyperfiltration at baseline more than doubled the risk of developing micro-or macroalbuminuria at follow-up. However, not all studies allowed for confounding factors or regression dilution bias. Future studies will therefore need to address the independent role of hyperfiltration, not only in the evolution of albuminuria, but also in the subsequent decline of GFR.

show abstract

Section: Resolution Of Hyperfiltration In Clinical Trialsmentioning

confidence: 56%

The clinical significance of hyperfiltration in diabetes

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast to the MDRD equation, which was calculated from a large population in a multicenter study, CysC-based equations were created and validated in smaller samples using different gold standard measurements for GFR. Table 3 highlights some CysCbased equations for adults (29,45,(51)(52)(53)(54)(55)(56).…”

Section: Equations Estimating Gfr Based On Cystatin Cmentioning

confidence: 99%

“…The vast majority, when comparing bias, precision, accuracy, and correlation, found CysC-based equations to be superior to creatinine-based equations as estimates of GFR (45,52,53), while some reported no difference in the performance of CysC-and creatinine-based equations (29,54). Recently, in order to improve the estimated kidney function, estimated GFR equations were developed, which incorporate both SCr and CysC.…”

Section: Equations Estimating Gfr Based On Cystatin Cmentioning

confidence: 99%

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Salgado

Neves

Bastos

et al. 2010

Braz J Med Biol Res

View full text Add to dashboard Cite

“…El-Shafey i saradnici [19] su pokazali da je oblast koju pokriva ROC kriva bila najviša za jednačinu JGF iz cistatina C u odnosu na jednačinu iz kreatinina i 24-časovni kreatinin. Slične rezultate pokazao je MacIsaac sa saradnicima [20]. Oni su kod oboljelih od DM tipa 2 upoređivali jednačine JGF izračunate iz serumskog cistatina C i kreatinina, te dobijene vrijednosti JGF upoređivali sa referentnom metodom, odnosno klirensom dietilen-triaminopentaacidna kiselina.…”

Section: Diskusijaunclassified

Primjena cistatina C u određivanju jačine glomerularne filtracije kod oboljelih od tipa 2 dijabetes melitusa

Risović

Popović-Pejičić

Vlatković

2016

BII

View full text Add to dashboard Cite

Kratak sadržajUvod. Funkcija bubrega se u praksi najčešće procjenjuje izračunavanjem jačine glomerularne filtracije (JGF) na osnovu koncentracije kreatinina u serumu. Primjena relativno novijeg parametra, cistatina C pokazala se pouzdanom i osjetljivom u procjeni bubrežne funkcije. Cilj rada je bio da se kod oboljelih od dijabetes melitusa (DM) tipa 2 odredi JGF pomoću 24-časovnog klirensa kreatinina, primjenom jednačina iz serumskog kreatinina i cistatina C, te da se utvrdi stepen senzitivnosti i specifičnosti primjenjenih metoda.Metode. Šezdeset ispitanika, dobi od 40-70 godina starosti, podijeljeno je u dvije grupe od po 30 ispitanika: grupa oboljelih od DM tipa 2 i kontrolna grupa. Za određivanje JGF korišćen je 24-časovni klirens kreatinina, jednačine prema Modification of Diet in Renal Disease (MDRD) za kreatinin i Chronic Kidney Disease Epidemiology (CKD-EPI) za cistatin C.Rezultati. Prosječne vrijednosti serumskog cistatina C su bile statistički značajno više kod oboljelih od DM u poređenju sa kontrolnom grupom (p <0,001). Utvrđena je statistički visoko značajna pozitivna korelacija između JGF izračunate pomoću jednačina koje koriste koncentracije kreatinina i cistatina C u serumu (r =0,74, p< 0,001). Jednačina po CKD-EPI pokazala je veću senzitivnost i specifičnost kod svih ispitanika. Ova senzitivnost je bila izraženija kod oboljelih od DM i iznosila je za CKD-EPI 0,938, za MDRD 0,878, za 24-časovni klirens kreatinina 0,818, a specifičnost za CKD-EPI 0,878, za MDRD 0,867, a za 24-časovni klirens kreatinina 0,802.Zaključak. Koncentracija cistatina C u serumu se pokazala kao pouzdan, senzitivan i specifičan parametar za izračunavanje JGF, posebno osjetljiv kod osoba sa blagim smanjenjem funkcije bubrega.

show abstract

Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods

Abstract: Aims/hypothesis: We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes.

Cited by 152 publications

References 10 publications

The clinical significance of hyperfiltration in diabetes

The clinical significance of hyperfiltration in diabetes

Monitoring renal function: measured and estimated glomerular filtration rates - a review

Primjena cistatina C u određivanju jačine glomerularne filtracije kod oboljelih od tipa 2 dijabetes melitusa

Contact Info

Product

Resources

About