Estimating creatinine clearance in elderly patients with low serum creatinine concentrations

Smythe, Maureen A.; Hoffman, Janet; Kizy, Kawla; Dmuchowski, Carl

doi:10.1093/ajhp/51.2.198

Cited by 43 publications

(50 citation statements)

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“…Many authors have quoted an apparent relationship between BSA and GFR that stems from the work published in 1951 [24]. However, the original derivation for this postulated relationship is from much earlier work [13].…”

Section: Discussionmentioning

confidence: 99%

Poor correlation between body surface area and glomerular filtration rate

Dooley¹,

Poole²

2000

Cancer Chemother Pharmacol

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Section: Discussionmentioning

confidence: 99%

Poor correlation between body surface area and glomerular filtration rate

Dooley¹,

Poole²

2000

Cancer Chemother Pharmacol

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“…Because some studies suggest calculated Cl cr in the elderly may be overestimated when compared with a 24‐hour urine collection, many clinical practitioners round low S cr values to a standard value of 0.8 or 1 mg/dl . Studies evaluating this practice have produced conflicting results and have not provided a definitive answer to the utility of rounding S cr values . Further investigation of rounding low S cr values would provide better guidance in calculating Cl cr .…”

mentioning

confidence: 99%

Impact of Various Body Weights and Serum Creatinine Concentrations on the Bias and Accuracy of the Cockcroft‐Gault Equation

2012

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An unbiased C-G Cl(c) (r) can be calculated using actual body weight in underweight patients and ideal body weight in patients of normal weight. Using ABW(0.4) for overweight, obese, and morbidly obese patients appears to be the least biased and most accurate method for calculating their C-G Cl(c) (r) . Rounding S(c) (r) in patients with low S(c) (r) did not improve accuracy or bias of the Cl(cr) calculations.

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“…The findings are, however, controversial. Some of the findings encourage the actual serum creatinine to be used in underweight cases [7,12], whereas others recommend rounding the serum creatinine to a minimum level [6]. Estimated Cockcroft-Gault creatinine clearance for case #1 is 105.4 mL/min, whereas the normalization results in 88 mL/min.…”

Section: Discussionmentioning

confidence: 99%

Renal function overestimation in underweight and/or non-ambulatory patients

Keshavarzi

2015

Int J Clin Pharm

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Creatinine clearance estimation is widely used to evaluate the renal function of the patients in order to initiate or adjust the drugs dosage. However serum creatinine, as a muscle metabolism by-product, may not be a reliable parameter in underweight and/or non-ambulatory patients, such as geriatric, acquired immunodeficiency syndrome patients and bed-confined and cachexic cases. To avoid overestimation of the renal function in those patients, serum cystatin C can be considered as a sensitive and accurate alternative for serum creatinine.

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Estimating creatinine clearance in elderly patients with low serum creatinine concentrations

Cited by 43 publications

References 0 publications

Poor correlation between body surface area and glomerular filtration rate

Poor correlation between body surface area and glomerular filtration rate

Impact of Various Body Weights and Serum Creatinine Concentrations on the Bias and Accuracy of the Cockcroft‐Gault Equation

Renal function overestimation in underweight and/or non-ambulatory patients

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