Renal function overestimation in underweight and/or non-ambulatory patients

Keshavarzi, Fazlollah

doi:10.1007/s11096-015-0157-5

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Because of the small sample size expected for proteinuria, we only report descriptive variables and frequencies. In sensitivity analyses, we reanalysed the predictors of eGFR and CKD by ancestry; excluded persons with underweight (BMI < 18.5 kg/m 2 ) because of potential low creatinine with overestimation of the kidney function [26]; and reanalysed the data estimating GFR ≤ 60 mL/min/1.73 m 2 with the CKD-EPI equation. Outcomes in parentheses are mean (SE) and in square brackets are 95% confidence intervals unless stated otherwise.…”

Section: Methodsmentioning

confidence: 99%

Chronic kidney disease and kidney health care status: the healthy life in Suriname (HeliSur) study

et al. 2018

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The high cardiovascular risk burden in low- and middle-income countries is expected to lead to an explosive increase in chronic kidney disease (CKD). However, population data on CKD from these countries are scarce. Therefore, we assessed kidney health in Suriname. In the Healthy Life in Suriname (HeliSur) study, a random sample of the adult population, we collected data with standardized questionnaires, physical examination, and blood and urine samples analysed in a central laboratory. Prevalent CKD was graded with KDIGO guidelines. In addition, we assessed national data on prevalent renal replacement therapy (RRT), estimated the future need for RRT, and evaluated national kidney health work force and policies. We include 1117 participants (2.0‰ of the population), 63% women, 40% of African ancestry and 43% of Asian ancestry, with a mean age of 42.2 (SE 0.4) years. Blood pressure is elevated in 72% of the participants, 26% have diabetes or prediabetes, and 78% are obese or overweight. The prevalence of CKD is 5.4%, and around 0.3% have kidney failure, translating to approximately 1500 patients nationally (2690 per million population, pmp), with currently 516 patients (920 pmp) on dialysis. Based on the participants from the random population sample in CKD stage G3 or G4, we estimate that 6750–10,750 pmp may develop kidney failure within the next 10 years. However, specialized kidney health workforce is currently very limited, and specific national or local policies for CKD management are lacking. Since the large majority of the general population has one or more risk factors for CKD including elevated blood pressure, urgent action is needed to strengthen kidney health care and prevent a catastrophic rise in need for RRT in the coming years.

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Section: Methodsmentioning

confidence: 99%

Chronic kidney disease and kidney health care status: the healthy life in Suriname (HeliSur) study

et al. 2018

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“…In this condition, enalapril and other ACE-inhibitors conserve kidney tissue by lowering intraglomerular pressure [5] and estrogen can also play a beneficial role. In practice, renal status is usually monitored via estimated glomerular filtration rate (eGFR) derived from serum creatinine clearance, but this is less reliable in underweight conditions where serum cystatin C is preferred [6] . Here an unusual alignment of RUNX2, SALL1, and SAMD9 variants is presented in the context of additional intron mutations, where pediatric Covid-19 illness and renal injury emerged in the setting of early ovarian insufficiency.…”

Section: Introductionmentioning

confidence: 99%