We review various aspects of time-dependent fatigue behavior of a number of structural alloys in use or planned for use in advanced nuclear power generating systems. Materials included are types 304 and 316 stainless steel, Fe-2 1/4 Cr-1 Mo steel, and alloy 8Q0H. Examples of environmental effects, including both chemical and physical interaction, are presented for a number of environments. The environments discussed are high-purity liquid sodium, high vacuum, air, impure helium, and irradiation damage, including internal helium bubble generation.