Estimates of Genetic Parameters and Predicted Selection Responses for Growth, Fat and Lean Traits in Mice

Eisen, E. J.; Prasetyo, Hardi

doi:10.2527/jas1988.6651153x

Cited by 28 publications

(21 citation statements)

References 32 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I) for W21 (0.15) was lower than that for W42 (0.21), which was in agreement with the results reported by Eisen and Prasetyo [5] and, in a seminal paper, by Falconer [6]. Estimated heritabilities for these two traits were also in close agreement with those reported by Fernández et al [7] for litter weight using DFREML [23] on the same mice population as analysed here.…”

Section: Discussionsupporting

confidence: 91%

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Ibáñez‐Escriche

Mínguez²,

Nieto

et al. 2008

Genet. Sel. Evol.

View full text Add to dashboard Cite

-Data from an experimental mice population selected from 18 generations to increase weight gain were used to estimate the genetic parameters associated with environmental variability. The analysis involved three traits: weight at 21 days, weight at 42 days and weight gain between 21 and 42 days. A dataset of 5273 records for males was studied. Data were analysed using Bayesian procedures by comparing the Deviance Information Criterion (DIC) value of two different models: one assuming homogeneous environmental variances and another assuming them as heterogeneous. The model assuming heterogeneity was better in all cases and also showed higher additive genetic variances and lower common environmental variances. The heterogeneity of residual variance was associated with systematic and additive genetic effects thus making reduction by selection possible. Genetic correlations between the additive genetic effects on mean and environmental variance of the traits analysed were always negative, ranging from −0.19 to −0.38. An increase in the heritability of the traits was found when considering the genetic determination of the environmental variability. A suggested correlated canalised response was found in terms of coefficient of variation but it could be insufficient to compensate for the scale effect associated with an increase of the mean.

show abstract

Section: Discussionsupporting

confidence: 91%

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Ibáñez‐Escriche

Mínguez²,

Nieto

et al. 2008

Genet. Sel. Evol.

View full text Add to dashboard Cite

show abstract

“…These two characters showed heritabilities of 0.53 and 0.58, values higher than comparable estimates for young mice found in some previous studies with outbred populations [9,22,31,32]. On the other hand, Cheverud et al [11] discovered that QTL identified from an intercross of the Large and Small inbred strains accounted for 56% and 62%, respectively, of the variation in body weight in mice three weeks and six weeks of age.…”

Section: Genetic and Environmental Variancesmentioning

confidence: 62%

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice

et al. 2005

View full text Add to dashboard Cite

-We estimated heritabilities and genetic correlations for a suite of 15 characters in five functional groups in an advanced intercross population of over 2000 mice derived from a cross of inbred lines selected for high and low heat loss. Heritabilities averaged 0.56 for three body weights, 0.23 for two energy balance characters, 0.48 for three bone characters, 0.35 for four measures of adiposity, and 0.27 for three organ weights, all of which were generally consistent in magnitude with estimates derived in previous studies. Genetic correlations varied from −0.65 to +0.98, and were higher within these functional groups than between groups. These correlations generally conformed to a priori expectations, being positive in sign for energy expenditure and consumption (+0.24) and negative in sign for energy expenditure and adiposity (−0.17). The genetic correlations of adiposity with body weight at 3, 6, and 12 weeks of age (−0.29, −0.22, −0.26) all were negative in sign but not statistically significant. The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight.advanced intercross mice / body weight / genetic correlations / heritability / obesity

show abstract

“…Reported genetic correlation estimates from sib analyses of broilers (McCarthy and Siegel, 1983;Becker et al, 1984), turkeys (Havenstein et al, 1988b), quail (Sadjadi and Becker, 1980;Garwood and Diehl, 1987), and mice (Eisen and Prasetyo, 1988) all suggest that selection for decreased fatness alone will also decrease BW. A major selection goal of broiler and turkey breeding companies has been to select for high BW at a given age.…”

Section: Torttf Et Almentioning

confidence: 96%

Genetic and Phenotypic Relationships in Japanese Quail.

et al. 1991

View full text Add to dashboard Cite

Live BW, carcass data, and organ data taken at 34 days of age on approximately 1,000 quail of both sexes from 110 sires and 290 dams were utilized to estimate genetic parameters from the initial generation of a selection study. The birds represented a sample of a line selected for high 4-wk BW. Data were analyzed using Henderson's Method 3 (MM3) and restricted maximum likelihood (REML) with and without a relationship matrix. The paternal half-sib heritabilities for body, carcass, and organ weights in Japanese quail were moderate to high for most traits studied, suggesting that selection to increase or decrease these traits should be successful. With the exception of BW, abdominal fat (AF), and heart weights, maternal half-sib heritability estimates were smaller than paternal half-sib estimates. Heritability estimates of traits adjusted for BW tended to be lower than counterparts not adjusted for BW. The genetic correlations of BW with the other carcass measurements were positive, and tended to be moderate to high. The correlation of BW with AF was .34, suggesting that selection for increased BW alone will lead to a bird with more abdominal fat. The correlations of AF with the other traits tended to be low to moderate in magnitude, with three of the correlations being negative, suggesting correlated responses with other traits when selecting for increased or decreased AF would be small. Genetic correlations among various muscle measurements were all positive and most were high in magnitude, indicating that traits easiest to measure and collect can be used in a selection process. The genetic correlations among the organ measurements were positive and moderate as were the correlations of organ weights with muscle weights. Negative genetic correlation estimates between AF and muscle measures were obtained from analysis when BW was a covariate. The REML heritability estimates were higher than MM3 estimates and REML genetic correlation estimates were less extreme than MM3.

show abstract

Estimates of Genetic Parameters and Predicted Selection Responses for Growth, Fat and Lean Traits in Mice

Cited by 28 publications

References 32 publications

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice

Genetic and Phenotypic Relationships in Japanese Quail.

Contact Info

Product

Resources

About