Estimated Incidence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Olmsted County, Minnesota

Karger, Randy A.; Jeng, Samuel M.; Johnson, Douglas H.; Hodge, David O.; Good, Margaret S.

doi:10.1097/00061198-200306000-00002

Cited by 79 publications

(76 citation statements)

References 13 publications

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“…[3][4][5][6][7][8][9][10] While genetic variants other than LOXL1 polymorphisms might contribute to ES and EG, 11 these data suggest that environmental factors could also play a role in this syndrome. Established risk factors for ES and EG includes older age 12,13 and female sex. [12][13][14] Recent studies also indicate that relative to living in the middle or southern United States, residing in the northern tier of the continental United States is associated with increased risk of ES and EG.…”

Section: Resultsmentioning

confidence: 99%

“…Established risk factors for ES and EG includes older age 12,13 and female sex. [12][13][14] Recent studies also indicate that relative to living in the middle or southern United States, residing in the northern tier of the continental United States is associated with increased risk of ES and EG. 14,15 Only sparse data are available for other modifiable risk factors for ES and EG.…”

Section: Resultsmentioning

confidence: 99%

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The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts

Pasquale

Wiggs

Willett

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We examined the association between caffeine and caffeinated beverage consumption in relation to the risk of exfoliation glaucoma or exfoliation glaucoma suspect (EG/ EGS). METHODS.We followed 78,977 women from the Nurses' Health Study (NHS) and 41,202 men from the Health Professionals Follow-up Study (HPFS) who were at least 40 years of age, did not have glaucoma, and reported undergoing eye examinations from 1980 (NHS) or 1986 (HPFS) to 2008. Information on consumption of caffeine-containing beverages and potential confounders were repeatedly ascertained in validated followup questionnaires. Confirmation with medical record review revealed 360 incident EG/EGS cases. Multivariate rate ratios (RRs) for EG/EGS were calculated in each cohort and then pooled using meta-analytic techniques.RESULTS. Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ‡500 mg/day had a trend toward increased risk of EG/EGS that was not statistically significant (RR ¼ 1.43; 95% confidence interval [CI], 0.98-2.08); P trend ¼ 0.06). Compared to abstainers, those who drank ‡3 cups of caffeinated coffee daily were at increased risk of EG/EGS (RR ¼ 1.66; 95% CI, 1.09-2.54; P trend ¼ 0.02). These results were not materially altered after adjustment for total fluid intake. Associations were stronger among women with a family history of glaucoma (P interaction ¼ 0.06 for coffee; P interaction ¼ 0.03 for caffeine). We did not find associations with consumption of other caffeinated products (caffeinated soda, caffeinated tea, decaffeinated coffee or chocolate) and risk of EG/EGS (P trend ‡0.31).CONCLUSIONS. We observed a positive association between heavier coffee consumption with risk of EG/EGS in this large prospective study. (Invest Ophthalmol Vis Sci. 2012;53:6427-6433)

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts

Pasquale

Wiggs

Willett

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…The difference was not significant for the rest of the ocular optical components of hypermetropes between the two groups (Table 6). [10]. Its incidence varies between racial and ethnic groups with prevalence in Europe found to be from 6.3% in Norway to 1.1% in Greece [11,12].…”

Section: Resultsmentioning

confidence: 99%

Optical low-coherence reflectometry enables preoperative detection of zonular weakness in pseudoexfoliation syndrome

Bosnar¹,

Elabjer²,

Bušić³

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…Several decades later, an ocular pathologist Georgiana DvorakTheobald coined the term pseudoexfoliation to distinguish it from a similar ailment which sometimes affected glassblowers called true exfoliation syndrome which is caused by heat or "infrared-related changes in the anterior lens capsule" and is characterised by "lamellar delamination of the lens capsule." 9 Its cause is unknown, although there is speculation that there may be a genetic basis (such as mutation of LOXL1 gene). It is little more prevalent in women than men, with outdoor activity, brown cataract and in persons past the age of seventy.…”

Section: Discussionmentioning

confidence: 99%

A Non-Randomised, Comparative Cross-Sectional Study to Analyse the Significance of ‘Pressure-to-Cornea Index’ in Pseudoexfoliation Eyes With and Without Clinical Glaucoma

Amudha¹,

Rajeswari²,

Muralikrishnan³

et al. 2018

jemds

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BACKGROUND Pseudoexfoliation syndrome is an age-related systemic disease manifesting itself primarily in the eyes and is characterised by the accumulation of microscopic granular amyloid-like protein fibres. Pseudoexfoliation is the most commonly seen identifiable cause of secondary glaucoma. The significance is that, it has a more aggressive clinical course with higher IOP readings and is difficult to treat due to poor response to medications. Aim-To find out the distribution of PCI in patients with Pseudoexfoliation (PXF) and to find out whether PCI can be taken as a predictor for clinical open angle glaucoma (OAG) secondary to pseudoexfoliation. MATERIALS AND METHODSOurs was a non-randomised, cross-sectional observational study conducted over a period of 6 months among 112 eyes of patients above 40 years of age with pseudoexfoliation. The eyes were categorised into the following 4 groups: Group 1-Pseudoexfoliation syndrome; Group 2 -Eyes with pseudoexfoliation with normal corrected IOP but with glaucomatous disc and visual field changes; Group 3 -Eyes with pseudoexfoliation with raised IOP, but with normal disc and visual field; Group 4 -Pseudoexfoliative glaucoma. All the statistical analysis was done using statistical software IBM SPSS Ver. 21.0 (Armonk, NY). RESULTS49 eyes PXS as Group 1, 19 eyes in group 2, 16 eyes in group 3 and 28 eyes in Group 4. Kruskal-Wallis test was used to compare the IOP, CCT and PCI measurements between the groups -P value is <0.001 which is statistically significant. The mean, SD and range in non-glaucomatous and glaucomatous eyes were compared using Rank sum, Mann-Whitney U test -P value <0.001 is statistically significant. This study shows that PCI can differentiate between glaucomatous and non-glaucomatous eyes better than the IOP levels in eyes with Pseudoexfoliation. This can be highly helpful in PXS patients with high PCI, to have a close followup schedule and for early diagnosis and treatment of pseudoexfoliative glaucoma, so that further damage to optic nerve head can be prevented. CONCLUSIONIncreased PCI values in PXG patients can more accurately indicate the severity of glaucoma.

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Estimated Incidence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Olmsted County, Minnesota

Cited by 79 publications

References 13 publications

The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts

The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts

Optical low-coherence reflectometry enables preoperative detection of zonular weakness in pseudoexfoliation syndrome

A Non-Randomised, Comparative Cross-Sectional Study to Analyse the Significance of ‘Pressure-to-Cornea Index’ in Pseudoexfoliation Eyes With and Without Clinical Glaucoma

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