Estimated Glomerular Filtration rate (eGFR): A Serum Creatinine-based Test for the Detection of Chronic Kidney Disease and its Impact on Clinical Practice

Mula-Abed, Waad-Allah S.

doi:10.5001/omj.2012.87

Cited by 11 publications

(6 citation statements)

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“…The eGFR was used to evaluate renal function in terms of excretion and filtration and was calculated based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) from SCr. Higher eGFR values indicate better renal function, mild renal impairment was defined by an eGFR< 90 mL/ minute/1.73 m 2 , and the presence of CKD was defined as an eGFR< 60 mL/minute/1.73 m 2 [16]. Blood pressure was also measured by an automatic blood pressure machine (OMRON, HEM-759P, Japan).…”

Section: Laboratory Testsmentioning

confidence: 99%

Healthy adult vegetarians have better renal function than matched omnivores: a cross-sectional study in China

Cui

Wang

et al. 2020

BMC Nephrol

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Background: An appropriate diet is an important determinant of kidney health. However, the association between vegetarian diets and renal function is unclear. We aimed to study the association between vegetarian diets and renal function in healthy adults. Methods: A total of 269 vegetarians and 269 sex-and age-matched nonvegetarian omnivores were enrolled in this cross-sectional study. Basic characteristics and daily dietary intakes were assessed by face-to-face interviews. Blood samples were collected, and renal function was assessed by measuring blood urea nitrogen (BUN), serum creatinine (SCr), uric acid (UA) and the estimated glomerular filtration rate (eGFR). Blood pressure, fasting blood glucose and blood lipid profiles were also assessed. Results: The average age of the vegetarians was 35.4 ± 8.6 years, 82.2% of whom were female. We evaluated the association between vegetarian diets and renal function using multivariate analysis. Compared with omnivores, vegetarians had lower BUN [β = − 0.63, 95% confidence interval (CI): (− 0.88, − 0.38)], SCr [β = − 2.04, 95% CI:(− 4.10, 0.02)], and UA levels [β = − 15.15, 95% CI: (− 27.81, − 2.50)] and higher eGFRs [β = 4.04, 95% CI: (0.30, 7.78)] after adjusting for sex, age, body mass index (BMI), physical activity, alcohol consumption, smoking status, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), systolic pressure and fasting blood glucose. Further analysis of food composition and renal function showed that dietary fiber intake was significantly negatively associated with BUN [β = − 0.02, 95% CI: (− 0.03, 0.00)], SCr [β = − 0.14, 95% CI: (− 0.25, 0.04)], and UA levels [β = − 0.72, 95% CI: (− 1.36, 0.07)] and positively associated with the eGFR [β = 0.20, 95% CI: (0.00, 0.40)]. Conclusions: Healthy adult vegetarians have better renal function than omnivores, and the higher dietary fiber intake associated with vegetarian diets may contribute to the protective effect on renal function.

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Section: Laboratory Testsmentioning

confidence: 99%

Healthy adult vegetarians have better renal function than matched omnivores: a cross-sectional study in China

Cui

Wang

et al. 2020

BMC Nephrol

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“…The estimated glomerular filtration rate (eGFR) was computed using the 4-variable modification of diet in renal disease study equation. [13] The patients were divided into 2 groups according to their eGFR. The first group was the non-CKD group, consisting of patients with eGFR ≥ 60 mL/min/1.73 m 2 .…”

Section: Methodsmentioning

confidence: 99%

Challenges of transarterial therapy for hepatocellular carcinoma in patients with chronic kidney disease

Lin

Chang

et al. 2019

Medicine

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Poor outcomes of hepatocellular carcinomas (HCC) in chronic kidney disease (CKD) patients are well described. Transarterial therapy is the standard treatment for HCC, following which regular contrast-enhanced imaging for residual disease is recommended. CKD is considered a relative contraindication for transarterial therapy owing to renal failure.This retrospective study investigated the outcomes of transarterial therapy in HCC patients with CKD. In total, 132 HCC patients who received transarterial therapy were enrolled, of whom 36 had CKD. Most CKD patients were elderly, with mean age of diagnosis of 69.7 ± 11.4 years. Hypertension (odds ratio [OR]; 5.06; 95% confidence interval [Cl]; 1.83–13.94), hepatitis C virus carrier rate (OR; 4.12, 95% CI; 1.13–14.99) and diabetes (OR; 3.62, 95% CI; 1.22–10.72) were significant predictors for CKD in HCC patients. Post therapy, the estimated glomerular filtration rate significantly decreased 13.7% from baseline in the CKD patients (P = .03). There were more post-therapy complications than in the non-CKD group, e.g. acute renal failure and sepsis (P < .01 vs P < .01). Overall survival in the CKD group was significantly poor (10.9 ± 8.5 vs 23.5 ± 16.3 months, P < .01).The lower survival of CKD patients was unrelated to treatment modality or less contrast-enhanced imaging follow-up. Further research on patient care and factors leading to poor outcomes for CKD is needed.

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“…The eGFR was used to evaluate renal function in terms of excretion and ltration and was calculated based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) from SCr. Higher eGFR values indicate better renal function, mild renal impairment was de ned by an eGFR<90 mL/minute/1.73 m 2 , and the presence of CKD was de ned as an eGFR<60 mL/minute/1.73 m 2 [16].…”

Section: Laboratory Testsmentioning

confidence: 99%

Healthy adult vegetarians have better renal function than matched omnivores: a cross sectional study in China.

Cui

Wang

et al. 2020

Preprint

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Background: An appropriate diet is an important determinant of kidney health. However, the association between vegetarian diets and renal function is unclear. We aimed to study the association between vegetarian diets and renal function in healthy adults. Methods: A total of 269 vegetarians and 269 sex- and age-matched nonvegetarian omnivores were enrolled in this cross-sectional study. Basic characteristics and daily dietary intakes were assessed by face-to-face interviews. Blood samples were collected, and renal function was assessed by measuring blood urea nitrogen (BUN), serum creatinine (SCr), uric acid (UA) and the estimated glomerular filtration rate (eGFR). Blood pressure, fasting blood glucose and blood lipid profiles were also assessed.Results: The average age of the vegetarians was 35.4±8.6 years, 82.2% of whom were female. We evaluated the association between vegetarian diets and renal function using multivariate analysis. Compared with omnivores, vegetarians had lower BUN [β= -0.63, 95% confidence interval (CI): (-0.88 , -0.38)], SCr [β= -2.04, 95% CI:(-4.10, 0.02)], and UA levels [β= -15.15, 95% CI: (-27.81, -2.50)] and higher eGFRs [β= 4.04, 95% CI: (0.30, 7.78)] after adjusting for sex, age, body mass index (BMI), physical activity, alcohol consumption, smoking status, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), systolic pressure and fasting blood glucose. Further analysis of food composition and renal function showed that dietary fiber intake was significantly negatively associated with BUN [β= -0.02, 95% CI: (-0.03, 0.00)], SCr [β= -0.14, 95% CI: (-0.25, 0.04)], and UA levels [β= -0.72, 95% CI: (-1.36, 0.07)] and positively associated with the eGFR [β= 0.20, 95% CI: (0.00, 0.40)]. Conclusions: Healthy adult vegetarians have better renal function than omnivores, and the higher dietary fiber intake associated with vegetarian diets may contribute to the protective effect on renal function.

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Estimated Glomerular Filtration rate (eGFR): A Serum Creatinine-based Test for the Detection of Chronic Kidney Disease and its Impact on Clinical Practice

Cited by 11 publications

References 0 publications

Healthy adult vegetarians have better renal function than matched omnivores: a cross-sectional study in China

Healthy adult vegetarians have better renal function than matched omnivores: a cross-sectional study in China

Challenges of transarterial therapy for hepatocellular carcinoma in patients with chronic kidney disease

Healthy adult vegetarians have better renal function than matched omnivores: a cross sectional study in China.

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