Estimated genetic associations among reproductive traits in Nellore cattle using Bayesian analysis

Costa, Edson Vinícius; Ventura, Henrique Torres; Veroneze, Renata; Silva, Fabyano F.; Pereira, Mariana; Lopes, Paulo Sávio

doi:10.1016/j.anireprosci.2020.106305

Cited by 11 publications

(13 citation statements)

References 28 publications

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“…Handcock et al, 2020 The probability of a cow remain in the herd enough time to raise a certain number of calves that pay for her development and maintenance costs. Costa et al, 2020 The ability of the cow to calve at least three times until 76 months of age. Ramos et al, 2020 The measure of whether or not an animal remains and produces in the herd until a specified point in time.…”

Section: Longevitymentioning

confidence: 99%

Analysis of Longevity Traits in Holstein Cattle: A Review

et al. 2021

Front. Genet.

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Dairy cow longevity is an essential economic trait that can supplement the breeding value of production traits, which is related to the herd time and lifetime milk yield of dairy cows. However, longevity is a relatively difficult trait to select for dairy cow breeding due to low heritability and numerous influence factors of the longevity in dairy cows. Longevity trait has been used as an important breeding target of a comprehensive selection index in many dairy developed countries; however, it has not been included in performance index in many developing countries. At present, cows in these countries are still in the primary stage of “large quantity, low quality, high cost, and low yield.” The average parity of dairy cows is less than 2.7, which is difficult to maintain the production efficiency to meet the demands of the dairy industry. Therefore, there is an urgent need to select and breed for the longevity of dairy cows. The various definitions and models (including linear, threshold, random regression, sire, and survival analysis) of longevity were reviewed and standardized. Survival analysis is the optimal model to evaluate longevity, and the longevity heritability is 0.01–0.30 by using different definitions and models. Additionally, the relationship between longevity and other traits was summarized, and found that longevity was regulated by multiple factors, and there were low or medium genetic correlations between them. Conformation traits, milk production traits, reproductive traits, and health traits may be used as indicators to select and breed the longevity of dairy cows. The genetic assessment methods, heritability, influencing factors, importance, breeding, and genetics of longevity were reviewed in the manuscript, which could provide a valuable reference for the selective breeding to extend the productive life of Holstein cattle.

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Section: Longevitymentioning

confidence: 99%

Analysis of Longevity Traits in Holstein Cattle: A Review

et al. 2021

Front. Genet.

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“…Different studies reported that AFC and STAY present negative genetic correlation (−0.64 (−0.83–−0.44); −0.69 and −0.32 (−0.40–−0.25) [ 9 , 50 , 52 ]; thus, the decrease in AFC would lead to an increase in STAY. The acyl-CoA oxidase like ( ACOXL ) gene located in the BTA 11 was found in the regions associated with AFC and STAY, so the selection targeted to this gene would allow a possible gain for both traits.…”

Section: Resultsmentioning

confidence: 99%

“…However, the functional reproductive traits selection is limited due to its small-moderate heritability [ 8 , 9 ] and result in a slow genetic gain. These traits are controlled by many genes and have relatively low to moderate heritability; that is, they are strongly influenced by environmental factors [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…These traits are controlled by many genes and have relatively low to moderate heritability; that is, they are strongly influenced by environmental factors [ 10 ]. Thus, a small proportion of the phenotypic variance may be explained by genetic variance [ 9 ]. Furthermore, most reproductive traits are measured late in the life of the animals and are limited by sex, making selection and genetic gain difficult [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle

Sbardella¹,

Watanabe²,

Costa³

et al. 2021

Animals

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The identification of genomic regions associated with reproductive traits as well as their biological processes allows a better understanding of the phenotypic variability of these traits. This information could be applied to animal breeding programs to accelerate genetic gain. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNP) with a scrotal circumference at 365 days of age (SC365) and at 450 days of age (SC450), gestation length (GL) as a calf trait, age at first calving (AFC), accumulated productivity (ACP), heifer early calving until 30 months (HC30), and stayability (STAY) traits, in order to identify candidate genes and biological pathways associated with reproductive traits in Nelore cattle. The data set consisted of pedigree, phenotypes, and genotypes of Nelore cattle from the “Associação Nacional de Criadores e Pesquisadores” (ANCP). The association analyses were performed using the Weighted Single-Step Genome-Wide Association method; the regions, consisting of 10 consecutive SNP, which explained more than 0.5% of additive genetic variance, were considered as a significant association. A total of 3, 6, 7, 5, 10, 25, and 12 windows were associated with SC355, SC450, GL, AFC, ACP, HC30, and STAY, respectively. The results revealed genes with important functions for reproductive traits, such as fertility and precocity. Some genes were associated with more than one trait, among them CAMK1D, TASP1, ACOXL, RAB11FIP5, and SFXN5. Moreover, the genes were enriched in functional terms, like negative regulation of fat cell differentiation, fatty acid alpha-oxidation, and sphingolipids signaling pathway. The identification of the genes associated with the traits, as well as genes enriched in the terms and pathway mentioned above, should contribute to future biological validation studies and may be used as candidate genes in Nelore breeding programs.

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“…Furthermore, most reproductive traits have low to moderate heritability estimates, therefore, reduced genetic progress is usually attained per time unit [5,6]. Despite the high environmental influence on reproductive traits (i.e., low to moderate heritability estimates), there is enough genetic variability to enable genetic progress through direct selection [7,8]. Therefore, identifying novel phenotypes that better represent the biological mechanisms underlying reproductive performance could be of great value to beef cattle breeding programs, especially in Zebu cattle breeds raised in tropical conditions.…”

Section: Introductionmentioning

confidence: 99%

Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle

Grigoletto

Santana

Bressan

et al. 2020

Animals

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Reproductive efficiency plays a major role in the long-term sustainability of livestock industries and can be improved through genetic and genomic selection. This study aimed to estimate genetic parameters (heritability and genetic correlation) and identify genomic regions and candidate genes associated with anti-Müllerian hormone levels (AMH) and antral follicle populations measured after estrous synchronization (AFP) in Nellore cattle. The datasets included phenotypic records for 1099 and 289 Nellore females for AFP and AMH, respectively, high-density single nucleotide polymorphism (SNP) genotypes for 944 animals, and 4129 individuals in the pedigree. The heritability estimates for AMH and AFP were 0.28 ± 0.07 and 0.30 ± 0.09, and the traits were highly and positively genetically correlated (rG = 0.81 ± 0.02). These findings indicated that these traits can be improved through selective breeding, and substantial indirect genetic gains are expected by selecting for only one of the two traits. A total of 31 genomic regions were shown to be associated with AMH or AFP, and two genomic regions located on BTA1 (64.9–65.0 Mb and 109.1–109.2 Mb) overlapped between the traits. Various candidate genes were identified to be potentially linked to important biological processes such as ovulation, tissue remodeling, and the immune system. Our findings support the use of AMH and AFP as indicator traits to genetically improve fertility rates in Nellore cattle and identify better oocyte donors.

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Estimated genetic associations among reproductive traits in Nellore cattle using Bayesian analysis

Cited by 11 publications

References 28 publications

Analysis of Longevity Traits in Holstein Cattle: A Review

Analysis of Longevity Traits in Holstein Cattle: A Review

Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle

Genetic Parameters and Genome-Wide Association Studies for Anti-Müllerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle

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