Estimate of prevalence of glucose intolerance in chronic liver disease. Degree of agreement among some diagnostic criteria

Buzzelli, G; Chiarantini, E; Cotrozzi, G; Relli, P; Matassi, L; Romanelli, Roberto Giulio; Geñtilini, Paolo

doi:10.1111/j.1600-0676.1988.tb01016.x

Cited by 29 publications

(12 citation statements)

References 9 publications

(2 reference statements)

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“…reported that, of 28 patients with chronic liver disease, 43% had normal glucose tolerance (NGT), 25% had impaired glucose tolerance (IGT) and 32% had DM at an oral glucose tolerance test (OGTT). Subsequent studies confirmed that abnormalities of glucose tolerance occur frequently in cirrhotic patients . In particular, Müller et al .…”

Section: Epidemiologymentioning

confidence: 77%

Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

Orsi

Grancini

Menini

et al. 2016

Liver International

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By definition, hepatogenous diabetes is directly caused by loss of liver function, implying that it develops after cirrhosis onset. Therefore, it should be distinguished from type 2 diabetes developing before cirrhosis onset, in which specific causes of liver disease play a major role, in addition to traditional risk factors. Currently, although hepatogenous diabetes shows distinct pathophysiological and clinical features, it is not considered as an autonomous entity. Recent evidence suggests that the failing liver exerts an independent "toxic" effect on pancreatic islets resulting in β-cell dysfunction. Moreover, patients with hepatogenous diabetes usually present with normal fasting glucose and haemoglobin A levels and abnormal response to an oral glucose tolerance test, which is therefore required for diagnosis. This article discusses the need to separate hepatogenous diabetes from type 2 diabetes occurring in subjects with chronic liver disease and to identify individuals suffering from this condition for prognostic and therapeutic purposes.

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Section: Epidemiologymentioning

confidence: 77%

Hepatogenous diabetes: Is it time to separate it from type 2 diabetes?

Orsi

Grancini

Menini

et al. 2016

Liver International

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“…Alavian et al [12] in their study, however, reported a signifi cant association of diabetes with higher Child-Pugh score. Earlier, Buzzelli et al [15] had also reported a positive correlation between the prevalence of diabetes and/or IGT and severity of hepatic impairment.…”

Section: Discussionmentioning

confidence: 92%

“…[12] Kobashi et al [11] in their study from Mexico reported nearly 23% prevalence of type 2 diabetes among the CLD patients. Earlier, Buzzelli et al [15] had documented a high prevalence of both impaired glucose tolerance and diabetes in CLD.…”

Section: Discussionmentioning

confidence: 98%

A cross-sectional study on occurrence of type 2 diabetes among patients admitted with chronic liver diseases in a medical college in Kolkata

Mukherjee¹,

Sarkar²,

Das³

et al. 2013

Int J Med Public Health

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Objectives:To study the magnitude of the problem of type 2 diabetes mellitus and impaired glucose intolerance among the patients with various types of chronic liver diseases and to fi nd out the association of diabetes mellitus and impaired glucose tolerance with the demographic and clinical characteristics of the patients. Materials and Methods: This observational study, which was cross-sectional in design, was undertaken in the Department of General Medicine at a medical College in Kolkata during October 2010 to July 2011. Altogether 161 patients diagnosed with chronic liver disease (CLD) were admitted in the General Medicine ward during the study period, out of which 9 patients got themselves discharged against medical advice. From the remaining 152 patients, a total of 136 patients aged 20 years and above were selected for the study according to the inclusion criteria. A detailed history was taken, and a thorough clinical examination was done followed by further investigations, all of which were recorded in a pre-designed, structured proforma. Results: Among the study subjects, 58.1% had impaired glucose tolerance (IGT), while 14.0% had overt diabetes mellitus. IGT and diabetes were signifi cantly higher among the CLD patients aged 45 years or more (P < 0.05). However, similar association was not observed with regard to sex of the patients. No association was found between the occurrence of IGT and/or overt diabetes with either severity (as per Child-Pugh score) or with the duration of CLD. More than half of the study subjects having alcoholic liver disease or chronic hepatitis B or C or autoimmune hepatitis and one third of those having Wilson's disease had IGT, while one third of those with either chronic hepatitis C or Wilson's disease and one fourth of those having autoimmune hepatitis had overt diabetes. Twenty-one percent of those with chronic hepatitis B also found to have overt diabetes, which was least in those with alcoholic liver disease. However, the overall glycemic status had no signifi cant relation with the etiology of CLD. Conclusion: It can be concluded that the occurrence of diabetes and IGT could be a matter of great concern in CLD patients, indicating towards the need for regular monitoring of the glycemic status in these patients, which would have a defi nite bearing upon the treatment strategy. Abstract Access this article onlineWebsite: www.ijmedph.org

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“…Actually, the existence of the hepatogenous diabetes (HD) which developed as a complication of cirrhosis was suspected by Naunyn as early as in 1898 . From then on, many studies have demonstrated that IR and glucose intolerance were common in patients with early stages of chronic liver diseases . Diabetes manifests clinically as the liver function deteriorates; thus, the HD can be considered as a marker of advanced liver disease.…”

Section: Discussionmentioning

confidence: 99%