Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta‐analysis

Background & Aims: The involvement of thyroid autoimmunity and dysfunction in patients with chronichepatitis C virus (HCV) infection before interferon-α (IFN-α) therapy remains controversial. We performedthis meta-analysis to evaluate the association of HCV infection with the presence of anti-thyroid antibodiesand dysthyroidism. Methods: A literature search was carried out to collect articles dated up to August 2015 to identify observationalstudies which compared the prevalence of anti-thyroid antibodies and thyroid dysfunction in IFN-α naïvechronic HCV-infected subjects with non-HCV infected controls. Random-effect or fixed-effect meta-analyseswere applied and results reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Twelve studies were included, involving 1,735 HCV-infected and 1,868 non-HCV infected subjects.Pooled anti-thyroid antibody prevalence tended to be higher in HCV-infected subjects. The prevalence ofanti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyroid microsomalantibody (ATMA) were 2.40-fold, 1.96-fold and 1.86-fold higher in HCV-infected subjects than in controls,respectively. The prevalence of hypothyroidism also differed by HCV infection status, with a pooled risk of3.10 (95%CI: 2.19-4.40) in HCV-infected subjects. However, the results did not show a significant differencein the prevalence of hyperthyroidism between the two groups.Conclusion: Chronic HCV infection may be an independent risk factor for thyroid disturbance. It is advisablefor the clinicians to monitor both thyroid antibodies and function in the course of chronic HCV infection,independent of IFN-α treatment. Abbreviations: AITD: autoimmune thyroid disease; ATMA: anti-thyroid microsomal antibody; CHC:chronic hepatitis; GD: Graves’ disease; HCV: hepatitis C virus; HT: Hashimoto’s thyroiditis; IFN-α: interferonalpha;NOS: Newcastle-Ottawa quality assessment scale; T3: triiodothyronine; T4: thyroxine; TGAb: antithyroglobulinantibody; TPOAb: anti-thyroid peroxidase antibody.

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“…The odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated for dichotomous outcomes [12].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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“…Publication bias was evaluated with the rank correlation test (Begg's test), the regression asymmetry test (Egger's test), and the funnel plots visually. 17 Meta-regression was performed to investigate the sources of heterogeneity in the included studies. Subgroup analysis was performed according to the study design (randomized or nonrandomized studies).…”

Section: Methodsmentioning

confidence: 99%

Survival Benefits With Artificial Liver Support System for Acute-on-Chronic Liver Failure

Shen

Wang

et al. 2016

Medicine

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“…37,38 However, HBV-related cirrhosis is an independent risk factor for DM. 37 Among PLHIV, the impact of chronic hepatitis B on occurrence of DM has been poorly evaluated. In the Swiss HIV cohort, in line with our results, evidence regarding an association with chronic hepatitis B was inconclusive.…”

Section: By Univariate Analysis (mentioning

confidence: 99%

Risk of diabetes in HIV‐infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort

Provoost¹,

Dramé²,

Cotte³

et al. 2018

Aliment Pharmacol Ther

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Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta‐analysis

Abstract: Our findings suggest that while HBV itself may not be pro-diabetic, the HBV-derived cirrhosis is an independent risk factor for T2DM.

Cited by 39 publications

References 38 publications

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Survival Benefits With Artificial Liver Support System for Acute-on-Chronic Liver Failure

Risk of diabetes in HIV‐infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort

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