Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service—7 year review in tertiary unit

Tavassoli, Shokufeh; Wach, Richard; Haynes, Richard; Markham, R.H.; Williams, Cathy

doi:10.1038/s41433-018-0330-x

Cited by 9 publications

(6 citation statements)

References 15 publications

(17 reference statements)

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“…Worldwide, retinopathy of prematurity (ROP) continues to be an important cause of childhood blindness [1, 2]. Although usually self-limiting, ROP requires treatment in approximately 8% of the overall screened population to prevent irreversible visual impairment [3]. Major risk factors of ROP are gestational age (GA) and birth weight (BW) [1].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts

Trzcionkowska¹,

Groenendaal²,

Andriessen³

et al. 2021

Neonatology

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Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP. Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Ophthalmologists provided data of screened infants, which were combined with risk factors from the national perinatal database (Perined). Clinical data and potential risk factors were compared to the first national ROP inventory (NEDROP-1, 2009). During the second period, more strict risk factor-based screening inclusion criteria were applied. Results: Of 1,287 eligible infants, 933 (72.5%) were screened for ROP and matched with the Perined data. Any ROP was found in 264 infants (28.3% of screened population, 2009: 21.9%) and severe ROP (sROP) (stage ≥3) in 41 infants (4.4%, 2009: 2.1%). The risk for any ROP is decreased with a higher GA (odds ratio [OR] 0.59 and 95% confidence interval [CI] 0.54–0.66) and increased for small for GA (SGA) (1.73, 1.11–2.62), mechanical ventilation >7 days (2.13, 1.35–3.37) and postnatal corticosteroids (2.57, 1.44–4.66). For sROP, significant factors were GA (OR 0.37 and CI 0.27–0.50), SGA (OR 5.65 and CI 2.17–14.92), postnatal corticosteroids (OR 3.81 and CI 1.72–8.40), and perforated necrotizing enterocolitis (OR 7.55 and CI 2.29–24.48). Conclusion: In the Netherlands, sROP was diagnosed more frequently since 2009. No new risk factors for ROP were determined in the present study, apart from those already included in the current screening guideline.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts

Trzcionkowska¹,

Groenendaal²,

Andriessen³

et al. 2021

Neonatology

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“…Some articles contain the data of both individual and multiple centers. For example, in England, there are Bristol Eye Hospital (individual) [25], NHS operational data (161 medical units), the British Ophthalmic Surveillance Unit, and a national collaborative ROP special interest groups (327 groups) (multiple) [26,27]. In Germany, there are Bonn/Freiburg cohort ROP Registry [28], a single medical center in Hannover (individual) [29], ROP Registry, and the IQTIG database (multiple) [28].…”

Section: Resultsmentioning

confidence: 99%

“…The number of screenings in the UK was reported, and the possibility of improving them for faster diagnosis and early treatment of ROP was discussed. The study by Tavassoli et al [25], is a report from the Bristol Eye Hospital unit based on data from 2009-2015. The total number of children screened was 1152; 95 (8.2%) of them received treatment.…”

Section: Englandmentioning

confidence: 99%

“…An increase of 8.1% in children requiring treatment was observed (2009: 5.7%; 2015: 13.8%), which, similarly to the Dutch study by Trzcionkowska et al [6], was linked to a higher number of surviving preterm babies, among other factors. The treatment of ROP was mainly laser therapy in 86% (82 out of 95), while an additional second diode laser treatment was required in 14% of children (13 out of 95), including only 5.3% (5 out of 95) with diode laser only, diode laser with anti-VEGF injection in 7.4% (7 out of 95), and diode laser with subsequent vitrectomy in 1.1% [25]. A nationwide population-based study of 327 groups across England by Adams et al [27], was performed between December 2013 and December 2014 by the British Ophthalmic Surveillance Unit and a National Collaborative ROP Special Interest Group.…”

Section: Englandmentioning

confidence: 99%

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Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Modrzejewska

Bosy-Gąsior

2023

JCM

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Introduction: Global predictions indicate that the incidence of retinopathy of prematurity (ROP) is increasing, but the lack of current epidemiological data on the occurrence of ROP in Europe prompted the authors to update these data. Methods: European studies related to the presence of ROP were analyzed, and the reason for the differences in the percentage of ROP and different screening criteria were checked. Results: The study presents results from individual and multiple centers. Current ROP incidence data varies from a low of 9.3% in Switzerland to the highest values of 64.1% in Portugal and 39.5% in Norway. The national screening criteria are used in the Netherlands, Germany, Norway, Poland, Portugal, Switzerland, and Sweden. Uniform criteria—Royal College of Paediatrics and Child Health guidelines are used in England and Greece. American Academy of Pediatrics screening guidelines are used in France and Italy. Conclusions: The epidemiology of ROP in European countries varies significantly. The increase in the diagnosis and treatment rate of ROP in recent years correlates with the narrowing of diagnostic criteria in newly issued guidelines (which include the WINROP and G-ROP algorithms), a higher number of less developed preterm infants, and a lower percentage of live births.

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“…We thank Tavassoli et al for their report on the increase in number of neonates requiring laser treatment for retinopathy of prematurity (ROP) seen in the UK associated with the improved survival of extremely preterm babies [1]. In addition, we wish to draw attention to those preterm infants at higher gestational ages with congenital abnormalities who previously had significant mortality, but who now survive the neonatal period, and who are also at risk of ROP.…”

Section: To the Editormentioning

confidence: 99%

Comment on: Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service—7 year review in tertiary unit

MacKinnon

Low

Sharma

et al. 2019

Eye

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Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service—7 year review in tertiary unit

Cited by 9 publications

References 15 publications

Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts

Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts

Most Up-to-Date Analysis of Epidemiological Data on the Screening Guidelines and Incidence of Retinopathy of Prematurity in Europe—A Literature Review

Comment on: Estimate of incidence of ROP requiring treatment in extreme preterms and impact on service—7 year review in tertiary unit

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