Esthesioneuroblastoma: The impact of treatment modality

Abstract

Surgical resection plus adjuvant radiation therapy yielded the best treatment outcome. More effective chemotherapy agents with a reproducible effectiveness are needed for patients with locally advanced esthesioneuroblastoma.

Esthesioneuroblastoma and Cervical Lymph Node Metastases: Clinical and Therapeutic Implications

“…For instance, Bailey and Barton (40) found only 8 patients with cervical lymph node metastases (7.2%), not 24 (22%); adjusting for these errors, the cumulative metastatic rate should be 18.8%. Unfortunately this error recurs in recent papers (41).…”

Esthesioneuroblastoma of the Nasal Cavity

“…3,4,8,[11][12][13][14][15] Although the superiority of combined therapy in stage B and C patients has been clearly demonstrated, 3,4,16 several studies did not find a benefit to adding postoperative RT in stage A patients with negative surgical margins. 1,16 Most institutions currently favor craniofacial resection, however, and several studies have shown promising results using less invasive endoscopic sinus surgery.…”

Esthesioneuroblastoma with bilateral metastases to the parotid glands

“…Overall, risk of local recurrence remains the most consistent feature manifesting in 30% of patients. Cervical node metastasis is known to occur in 23% of cases and is best managed with neck dissection followed by radiotherapy . Currently, there is limited evidence to suggest that elective surgery or radiotherapy is beneficial to patients with N0 disease .…”