Esters of three species ofFerula

Saidkhodzhaev, Ashraf I.; Golovina, L. A.; Malikov, V. M.; Melibaev, S.; Rakhmankulov, U.

doi:10.1007/bf00574228

Cited by 3 publications

(3 citation statements)

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“…In addition, the phytochemistry of the different species of this genus is discussed over the period of 2000-to the present time (March 2018). It is also noteworthy that before the year 2000, many reports were published relating to natural bioactive sulfur compounds (Al-Said et al, 1996), triterpenes (Diaz et al, 1984;Díaz et al, 1984), sesquiterpene esters (Miski et al, 1983;Miski et al, 1984;Razdan et al, 1989;Appendino et al, 1990;González et al, 1993;Khalilova and Saidkhodzhaev, 1998a), sesquiterpene derivatives of the farnesylbenzofuranone type (Kojima et al, 1999), esters (Saidkhodzhaev et al, 1985a;Saidkhodzhaev et al, 1985b;Golovina et al, 1987;Kerimov et al, 1987;Saidkhodzhaev et al, 1993b;Saidkhodzhaev et al, 1993d;Kobilov et al, 1995b, a;Nazhimutdinova et al, 1995), isocarotane esters (Garg et al, 1998), daucane esters (Miski and Mabry, 1985;Miski and Jakupovic, 1990;Appendino et al, 1997), sesquiterpene coumarins (Buddrus et al, 1985;Nassar et al, 1995;Ahmed, 1999), sesquiterpene lactones (Kir'yalov and Serkerov, 1966;Bagirov et al, 1979a, b;Bagirov et al, 1984;Sagitdinova et al, 1991;Serkerov et al, 1992;Kabilov et al, 1994), terpenoids (Nazhimitdinova and Saidkhodzhaev, 1993;Saidkhodzhaev et al, 1993a;Saidkhodzhaev and Mamatkhanov, 1995;…”

Section: Phytochemistry Of the Ferula Species (2000 To March 2018)mentioning

confidence: 99%

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Mohammadhosseini

Venditti

Sarker

et al. 2019

Industrial Crops and Products

124

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This study aims to provide a comprehensive overview of the medicinal, folkloric and traditional culinary uses of Ferula species, related products and extracts in different countries together with the description of recently isolated new components and the related bioactivities. The phytochemical composition of the essential oils (EOs), oleo-gum-resin (OGR) and the non-volatile fractions obtained from several endemic and indigenous Ferula species is also reported. A special emphasis is placed on their unusual components, i.e. sulfur-containing volatiles from the EOs and the new phytochemicals with mixed biogenetic origins. More than 180 chemical constituents (excluding common essential oils components), including sulfur-containing metabolites, terpenoids, coumarins, sesquiterpene coumarins, etc., as both aglycones and glycosides, are reported, along with their occurrence and biological activities when available. A large number of new secondary metabolites, belonging to different classes of natural products possessing interesting biological activities, from the antiproliferative to the anti-inflammatory to the neuroprotective ones, among the others, have been recently found in the Ferula genus. Several of these phytochemicals are exclusive to this genus; therefore may be considered chemotaxonomic markers. All these aspects are extensively discussed in this review.

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Section: Phytochemistry Of the Ferula Species (2000 To March 2018)mentioning

confidence: 99%

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Mohammadhosseini

Venditti

Sarker

et al. 2019

Industrial Crops and Products

124

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“…The co-occurrence of humulane and germacrane esters in a Ferula species is rare. In addition to the fruits of F. lycia , the association of similar compounds has been reported from the roots of F. lapidosa Korovin and F. tenuisecta Korovin …”

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confidence: 54%

“…In addition to the fruits of F. lycia, the association of similar compounds has been reported from the roots of F. lapidosa Korovin and F. tenuisecta Korovin. 19 All isolated compounds were tested in vitro for their cytotoxic activity against resistant chronic myeloid leukemia (CML) cell lines, Table 1. NMR Spectroscopic Data (300 MHz, CDCl including an imatinib-and dasatinib-resistant murine cell line (DA1-3b/M2 BCR-ABL ) and an imatinib-resistant human cell line (K562R).…”

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confidence: 99%

Humulane and Germacrane Sesquiterpenes from Ferula lycia

et al. 2010

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Five new juniferol esters (1-5), along with six known humulane derivatives (6-11), were isolated from the roots of Ferula lycia, an endemic Turkish species. The fruits of the same species were also investigated and led to the isolation of these same compounds, as well as two known germacrane esters (12 and 13). All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2(BCR-ABL). The two most active compounds, juniferinin (7) and 6-beta-p-hydroxybenzoyloxygermacra-1(10),4-diene (12), were moderately active against Raji lymphoma cells but also displayed some toxicity against healthy bone marrow cells.

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Aerial Part Ferula Tenuisecta Alternative Industrial Raw Material for the Production of Tefestrol Substance

Mamatkhanov¹,

Khalilov²

2022

JCPRM

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The main losses of tefestrol have been identified and the advantages and disadvantages of the existing technology in the production of the substance from the aerial parts of Ferula tenuisecta have been established. It was found that the final product obtained by the existing technology has a green color that does not meet the requirements of the Pharmacopoeia article. The stage proposed of extraction of the sum of esters of sesquiterpene alcohols from the aerial part of Ferula tenuisecta and purification of the obtained extract, allowing to subsequent obtain the substance of tefestrol without green color. It has been shown that the use of activated carbon makes it possible to remove the green color of the extract. To purify tefestrol from other esters of sesquiterpene alcohols and accompanying substances, a chromatographic separation on silica gel is proposed under the following conditions: the ratio of the amount introduced into the column and the sorbent is 1 : 20; the ratio of the height of the sorption layer to the column diameter is 4 : 1; elution rate 35 l/h.m2. To obtain the pharmacopoeial substance of tefestrol is proposed, crystallization of a technical product from a mixture of ethyl acetate with hexane in a volume ratio of 1 : 3. Based on the results obtained, technology has been developed for obtaining the tefestrol substance from the aerial part of Ferula tenuisecta. Using this technology 70.96% of the substance of tefestrol is obtained from the content in the raw material, according to the existing technology 33.9%.

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Esters of three species ofFerula

Cited by 3 publications

References 0 publications

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

The genus Ferula: Ethnobotany, phytochemistry and bioactivities – A review

Humulane and Germacrane Sesquiterpenes from Ferula lycia

Aerial Part Ferula Tenuisecta Alternative Industrial Raw Material for the Production of Tefestrol Substance

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