Esterification influence in thermosensitive behavior of copolymers PNIPAm-co-PAA and PNVCL-co-PAA in magnetic nanoparticles surface

Amantéa, Bruno Estevam; Piazza, Rodolfo Debone; Chacon, Jose; Santos, Caio Carvalho dos; Costa, Taciane Pereira da; Rocha, Caroline Oliveira da; Brandt, João Victor; Godoi, Denis Ricardo Martins de; Jafelicci, Miguel; Marques, Rodrigo Fernando Costa

doi:10.1016/j.colsurfa.2019.04.011

Cited by 14 publications

(10 citation statements)

References 18 publications

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“…It is also important to monitor the stability of nanoparticles as a function of pH levels [ 20 , 21 , 22 ]. Figure 7 shows the size and zeta potential results for nanoparticles created at three different pH levels (pH 5.5, 7.4, and 10).…”

Section: Resultsmentioning

confidence: 99%

Development and Physical Characterization of α-Glucan Nanoparticles

et al. 2020

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α-Glucans that were enzymatically synthesized from sucrose using glucansucrase cloned from Leuconostoc mesenteroides NRRL B-1118 were found to have a glass transition temperature of approximately 80 °C. Using high-pressure homogenization (~70 MPa), the α-glucans were converted into nanoparticles of ~120 nm in diameter with a surface potential of ~−3 mV. Fluorescence measurements using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicate that the α-glucan nanoparticles have a hydrophobic core that remains intact from 10 to 85 °C. α-Glucan nanoparticles were found to be stable for over 220 days and able to form at three pH levels. Accelerated exposure measurements demonstrated that the α-glucan nanoparticles can endure exposure to elevated temperatures up to 60 °C for 6 h intervals.

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Section: Resultsmentioning

confidence: 99%

Development and Physical Characterization of α-Glucan Nanoparticles

et al. 2020

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“…The estimation of 𝜉 𝜇 expressed as Equation ( 20) with 𝜅𝑎 ranging from 10 to 100 for the cases of 𝑛 = 0.9, 0.95, 1, 1.05, 1.1 is shown in Figure 8. Clearly, Equation (20) can roughly predict the variation tendency of thermodiffusion coefficient ratio with 𝜅𝑎 for both pseudoplastic and dilatant fluids. The deviation of 𝜉 𝜇 from the numerical 𝜉 is due to the following reasons: First, for ease of calculation, the dimensionless dynamic viscosity at the particle surface is applied for the calculation of Equation (20), and the dynamic viscosity variation near the particle surface is neglected; second, the reciprocal calculation is not a precise manipulation for thermophoresis in non-Newtonian fluids.…”

Section: Variation Of Thermodiffusion Coefficientmentioning

confidence: 87%

“…Thermophoresis is more frequently applied in a biomedical analysis with processed fluids as biofluids (e.g., blood and tissue solutions, protein and DNA solutions) [18,19]. In existing researches, thermophoresis is also studied for polymeric solutions [20] and concentrated colloidal suspensions [21]. These fluids cannot be treated as Newtonian fluids [22].…”

Section: Introductionmentioning

confidence: 99%

Numerical analysis of thermophoresis of charged colloidal particles in non‐Newtonian concentrated electrolyte solutions

et al. 2022

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Thermophoresis of colloidal particles in aqueous media is more frequently applied in biomedical analysis with processed fluids as biofluids. In this work, a numerical analysis of the thermophoresis of charged colloidal particles in non-Newtonian concentrated electrolyte solutions is presented. In a particle-fixed reference frame, the flow field of non-Newtonian fluids has been governed by the Cauchy momentum equation and the continuity equation, with the dynamic viscosity following the power-law fluid model. The numerical simulations reveal that the shear-thinning effect of pseudoplastic fluids is advantageous to the thermophoresis, and the shear-thickening effect of dilatant fluids slows down the thermophoresis. Both the shear-thinning and shear-thickening effects of non-Newtonian fluids on a thermodiffusion coefficient are pronounced for the case when the thickness of electric double layer (EDL) surrounding a particle is moderate or thin. Finally, the reciprocal of the dynamic velocity at the particle surface is calculated to approximately estimate the thermophoretic behavior of a charged particle with moderate or thin EDL thickness.

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Section: Introductionmentioning

confidence: 99%

“…Many studies have shown that the drug delivery and transport in tissues, cells and cellular organelles are improved when they are associated to colloidal nanomaterials by encapsulation or surface adsorption (Amantea et al., 2019); (Matsuoka et al., 2004); (Ito et al., 2003). Thus, several nanomaterials with biomedical relevance have been studied and applied in drug delivery platform including polymers (Debone et al., 2018), metal nanoparticles (Daraee et al., 2014), liposomes (Grijalvo, Mayr, Eritja, & Díaz, 2016), micelles (Biswas, Kumari, Lakhani, & Ghosh, 2016), metal‐organic frameworks (Lei et al., 2018) and mesoporous silica (Maggini et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Surface engineering of magnetic nanoparticles for hyperthermia and drug delivery

et al. 2020

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Magnetic nanoparticles (MNP) have emerged as a relevant material for biomedical applications based on drug delivery systems and magnetic hyperthermia. When carefully tailored, their surface properties can enhance the solubility, bioavailability, permeability, metabolism, excretion, cell internalization and recognition of many medicines, which are parameters highly desired when one think in the development and efficiency increasing of several therapies. Allied to it, an interesting synergism can be achieved by the use of magnetic fields as trigger of drug release from thermosensitive polymer-modified MNP or as a tool to increase accumulation of medicine in specific site. Faced it, here it shows how surface engineering of MNP can improve its biomedical relevance due to enhancement of cellular recognition, biocompatibility and drug release of several medicines. Furthermore, particular attention will be paid to the use of magnetic hyperthermia, which has acted synergic to improve MNP effects of many drug delivery systems.

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Esterification influence in thermosensitive behavior of copolymers PNIPAm-co-PAA and PNVCL-co-PAA in magnetic nanoparticles surface

Cited by 14 publications

References 18 publications

Development and Physical Characterization of α-Glucan Nanoparticles

Development and Physical Characterization of α-Glucan Nanoparticles

Numerical analysis of thermophoresis of charged colloidal particles in non‐Newtonian concentrated electrolyte solutions

Surface engineering of magnetic nanoparticles for hyperthermia and drug delivery

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