Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery

Abstract

Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

“…Although polymers linked through an ester bond or even polymers based themselves on ester bonds, such as poly(β-amino ester), have been reported as capping agents [ 90 , 91 ], this pH-sensitive bond finds further application as a linker between nanocarriers and more complex pore-blocking structures. As boronate ester hydrolysis is known to be reversible [ 109 ], researchers have taken advantage of that designing nanocarriers capped with small Au [ 92 ] or Fe 3 O 4 [ 93 ] nanoparticles through a boronate ester bond as on-off release systems.…”

Bio-inspired temporal regulation of ion-transport in nanochannels

“…[29][30][31][32][33] However, all such articial systems that demonstrated selective transport of molecules oen operate in a passive manner and lack autonomous behaviour, unlike their natural counterparts. [34][35][36][37][38][39][40][41][42][43][44][45] To alleviate this scenario, herein we report a unique temporal regulation of ion transport in synthetic nanochannels using a bio-inspired, chemical fuel-driven strategy. In order to show this concept of 'transient ion transport', we have used pH responsive, heterogeneously functionalized nanochannels of mesoporous silica particles as a model system (Scheme 1).…”

Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release

“…Meanwhile, Lin et al proposed the concept of “gatekeeper” and the guest molecules were blocked in the reservoir of MSNs by capping the pores with a gatekeeper . MSNs can be end‐capped with multitudinous gatekeepers, such as nanoparticles, supramolecular nanovalves, polymers, biomolecules, peptides, which can be triggered by internal stimuli or external stimuli including redox, pH, temperature, photo, enzymes, and magnetic signals . As we know, among these various gatekeepers, peptides are one of the most attractive types due to their inherent bioactivity, biodegradability and good biocompatibility .…”