Esteato-hepatite não alcoólica: uma síndrome em evidência

Ponte, Isabelle Meneses da; Lima, Matheus Eugênio de Sousa; Albuquerque, Matheus Couto Furtado; Veloso, Ana Flávia de Holanda; Bachur, Tatiana Paschoalette Rodrigues

doi:10.34119/bjhrv3n1-084

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…Non-alcoholic fatty liver disease (NAFLD) is a pathology resulting from the excessive accumulation of triglycerides in the liver (1). Because it is one of the most common forms of liver involvement, affecting approximately 25% of the world's population (2), it can be considered a public health problem (1,3). The pathophysiology of NAFLD stems from a triad of mechanisms: metabolic, environmental, and genetic (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials

Silva¹,

Santos²,

Lagares³

et al. 2023

Preprint

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Aim: To investigate how much aerobic and resisted physical exercise affects the behavior of AST and ALT proteins in the NAFLD spectrum. Background: Non-alcoholic fatty liver disease (NAFLD) is a pathology resulting from the excessive accumulation of triglycerides in the liver. The pathophysiology of the disease comes from several mechanisms, among them, metabolic, environmental, and genetic. The measurement of liver enzymes, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) are essential to perform a differential diagnosis of NAFLD with other pathologies that affect the liver. The non-pharmacological treatment of NAFLD is based on aerobic and resisted physical exercise, and one of its aims is to reduce the inflammatory markers AST and ALT. Materials and Methods: Systematic review carried out in PubMed, Scopus, Embase, and Cochrane databases. Clinical trials that evaluated the effect of physical exercise on NAFLD on AST and ALT enzymes were included. Results: A total of 24 clinical trials met the inclusion criteria, with a sample size of 1141 participants, aged 20-82 years. The study protocol varied between aerobic exercise and resistance exercise with a weekly frequency between 2-6 times a week, a duration of 20-90 minutes for aerobics, and an intensity between 50-80% of peak VO2 and/or maximum HR for the resisted. Of the 24 studies included, only five showed improvements in both enzymes in the intervention group. Conclusion: Physical exercise cannot make significant changes in the behavior of AST and ALT liver parameters.

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Section: Introductionmentioning

confidence: 99%

“…When there is liver damage, these are the enzymes most commonly found in liver tests, being essential for the diagnosis and monitoring of liver diseases (1,9,10). However, acute conditions may show higher values and lower/normal values may reflect chronic hepatitis (1,2).…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials

Silva¹,

Santos²,

Lagares³

et al. 2023

Preprint

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show abstract

“…Se houver suspeita de NAFLD ou NASH, serão feitos exames de sangue para verificar o funcionamento do fígado. Também podem ser utilizadas para auxiliar no processo de investigação ferramentas de imagem, como ressonância magnética ou ultrassom (PONTE et al, 2020).…”

Section: Introductionunclassified

Vitamina D No Tratamento De Esteato-Hepatite Não-Alcoólica: Uma Revisão Integrativa

SÁ

SILVA

Santos

2022

Unifunec Cient. Mult.

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Trata-se de um estudo de revisão integrativa, cujo objetivo foi avaliar como a literatura nas bases de dados Literatura Latino-Americana e do Caribe de Informação em Ciências da Saúde (LILACS), Biblioteca Virtual em Saúde (BVS) e SciELO, estabelece uma associação entre a vitamina D (VD) e a esteato-hepatite não-alcoólica (NASH ou NAFLD) e como o uso da suplementação dessa vitamina pode impedir a evolução da hepatopatia para estágios mais avançados, proporcionando melhor prognóstico e qualidade de vida aos pacientes. Para isso, foi realizada uma ampla pesquisa bibliográfica com características exploratórias, descritivas e coleta de dados qualitativa sobre o tratamento da VD na NASH, para a qual foram selecionados 10 artigos, de um total de 1067 trabalhos. Por meio da amostra selecionada, observa-se a necessidade da realização de novos ensaios clínicos randomizados com uma população maior, em um intervalo de tempo maior, aplicação de placebo e grupo controle, para que se possa ter segurança do público que pode se beneficiar com a suplementação de vitamina D. VITAMIN D IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS: AN INTEGRATIVE REVIEW ABSTRACT This is an integrative review study, which aims to evaluate how the literature in the databases Latin American and Caribbean Literature on Health Sciences Information (LILACS), Virtual Health Library (VHL) and SciELO, establishes an association between vitamin D (VD) and non-alcoholic steatohepatitis (NASH or NAFLD) and how the use of supplementation of this vitamin can prevent the evolution of hepatopathy to more advanced stages, providing better prognosis and quality of life for patients. To this end, a broad literature search with exploratory, descriptive characteristics and qualitative data collection on the treatment of VD in NASH was conducted, for which 10 articles were selected from a total of 1067 papers. Through the selected sample, new randomized clinical trials with a larger population, in a longer time span, placebo application, and control group are needed in order to assure the public that could benefit from vitamin D supplementation. Keywords: Liver disease. Supplementation. Vitamin D.

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Physical exercise and its effects on liver aminotransferases in non-alcoholic fatty liver disease: a review systematic

SILVA,

SANTOS,

LAGARES

et al. 2024

Gazz Med Ital - Arch Sci Med

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Esteato-hepatite não alcoólica: uma síndrome em evidência

Cited by 3 publications

References 2 publications

Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials

Physical Exercise and Changes in AST/ALT Rates in Non-Alcoholic Fatty Liver Disease: A Systematic Review of Clinical Trials

Vitamina D No Tratamento De Esteato-Hepatite Não-Alcoólica: Uma Revisão Integrativa

Physical exercise and its effects on liver aminotransferases in non-alcoholic fatty liver disease: a review systematic

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