Establishment of Quality Control Parameters of Nagarmotha Churna

Kansabanik, Subham; Mukhi, Sangeeta; Das, Chandan; Das, Debajyoti; Bose, Anindya

doi:10.5958/0974-360x.2019.01036.9

Cited by 2 publications

(1 citation statement)

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“…These findings demonstrate that the material was a pure methanolic extract compared to the chemical structure. 31,32…”

Section: Linear Modelmentioning

confidence: 99%

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

Patel,

Chaudhary,

Gandhi

2023

Int J. Pharm. Investigation

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Background: Momordica dioica (MD) is called the teasle gourd, spiny gourd, and kakrol. Among the important phytochemicals present in MD include alkaloids, flavonoids, phenolics, tannins, saponins, steroids, glycosides, and terpenes. These compounds have a high potential to cure many illnesses. Herbal plant extracts exhibit mucilage, high viscosity, and limited flowability qualities. It is challenging to create the herbal formulation because of these characteristics. Herbal medications may be one of the safest options with the fewest adverse effects. Objectives: Formulation and Optimization of a novel herbal tablet containing Momordica dioica extract by applying 3 2 factorial designs for the improvement of hardness and In vitro drug release. Materials and Methods: The tablets were made using Sodium Starch Glycolate (SSG) as a super disintegrant and Polyvinylpyrrolidone-K30 (PVP-K30) as a binder. The study was designed to optimize the formulation, and the model that resulted from that experiment was validated. Design Expert software 11 used a 3-level 2 factorial (3 2 ) design. Several pre-and post-compression characteristics were evaluated to determine the formulation's quality. Results: Formulated tablet batches B1 to B9 were tested for various parameters. It was discovered that the values ranged from 3.2 to 3.6 kg/cm 2 in hardness, 5.9 to 6.2 mm in thickness, 735-765 mg in weight variation, 18 to 27 sec to wet the tablet, 16 to 19 min to disintegrate, 0.25 to 0.51% in friability, and 98 to 101% in drug content. The best drug release and hardness were achieved with PVP K 30 (6%) and SSG (6%). A promising batch was found as batch B5. Conclusion: The findings suggest that PVP-K30 and SSG are the two best excipients when making herbal tablets.

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“…These findings demonstrate that the material was a pure methanolic extract compared to the chemical structure. 31,32…”

Section: Linear Modelmentioning

confidence: 99%

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

Patel,

Chaudhary,

Gandhi

2023

Int J. Pharm. Investigation

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Acute and Sub-acute Toxicity study of Amrtadi Churna

Mukhi

Bose

Das

et al. 2021

RJPT

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Amrtadi Churna is an Ayurvedic polyherbal formulation containing three herbs viz., Amalaki (Emblica officinalis), Gokshur (Tribulus terrestris) and Guduchi (Tinospora cordifolia). It is prescribed in India for immunomodulation and treating hyperacidity. The present work reports the acute and sub-acute toxicity assessment of Amrtadi Churna on experimental animals to rule whether it might produce toxicity on herb-herb interactions by combining its ingredient. The results showed that, the single administration of high dose (5000 mg/kg) of the Churna neither induced mortality nor any adverse toxicity signs in rats, suggesting its practically non-toxic nature in the therapeutic doses. Sub-acute toxicity testing results of hematology, serum biochemistry and organ histology showed that the product did not induce any toxic signs at the tested dose levels. However, it produced an apparently harmless hyperbilirubinemia without any signs of liver damage. There were no major gender specific variations except a few hematological parameters. It was concluded that, Amrtadi Churna could be relatively safe at therapeutic dose levels, ruling out any serious side effects by the interaction of its three herbal ingredients.

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Establishment of Quality Control Parameters of Nagarmotha Churna

Cited by 2 publications

References 0 publications

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

Acute and Sub-acute Toxicity study of Amrtadi Churna

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