Establishment of Long-Term Monitoring System for Blood Chemistry Data by the National Health and Nutrition Survey in Japan

Nakamura, Masakazu; Sato, Shinichi; Satō, Takashi; Konishi, Masamitsu; Yoshiike, Nobuo

doi:10.5551/jat.e575

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…Serum was separated and centrifuged soon after blood coagulation, and plasma samples were collected in siliconized tubes containing sodium fluoride and shipped to a central laboratory (SRL, Tokyo, Japan) for analysis. Serum total cholesterol was measured by the cholesterol dehydrogenase-ultraviolet (UV) method and standardized by the Centers for Disease Control and Prevention/US Collaborating Center for Reference Method Laboratory Network Research in Blood Lipids 27 ) . Triglycerides were measured using enzyme methods, and high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were measured using direct methods (Cholestest ® LDL Sekisui Medical).…”

Section: Methodsmentioning

confidence: 99%

Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010

Fujiyoshi

Arima

Satoh

et al. 2018

J Atheroscler Thromb

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Aim: To investigate associations between socioeconomic status (SES) and the prevalence and treatment status of hypercholesterolemia in a general Japanese population.Methods: In 2010, we established a cohort study of 2417 adults (age 20–91 yr) from 300 randomly selected areas across Japan who participated in the National Health and Nutrition Survey of Japan. We cross-sectionally examined an association between SES and (1) prevalence of hypercholesterolemia in 2417 participants (999 men and 1418 women) and (2) not receiving medication for hypercholesterolemia in 654 participants (215 men and 439 women). SES included employment status, marital status, length of education, and household expenditures. Hypercholesterolemia was defined as a total serum cholesterol level of ≥ 6.21 mmol/L (240 mg/dL) or the use of lipid-lowering medications.Results: The overall prevalence of hypercholesterolemia was 21.5% in men and 31.0% in women. In men, the lowest quintile of household expenditures was associated with a higher prevalence of hypercholesterolemia (28.3%) compared with the upper 4 quintiles (19.9%) (multivariable-adjusted odds ratio 1.66; 95% confidence interval [CI] 1.16–2.38). Among participants with hypercholesterolemia, 55.4% of men and 55.1% of women were not receiving medication. Unmarried men were more likely to be untreated (75.0%) than married men (50.9%) (multivariable-adjusted odds ratio 2.53; 95%CI 1.05–6.08). SES had no significant effects in women.Conclusion: In a general population of Japanese men, low household expenditures were associated with a higher prevalence of hypercholesterolemia, and unmarried men with hypercholesterolemia were less likely to receive medication.

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Section: Methodsmentioning

confidence: 99%

Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010

Fujiyoshi

Arima

Satoh

et al. 2018

J Atheroscler Thromb

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“…3 However, after 2008, more PHNS data became available, to allow for evaluation of local plans in Health Japan 21. In addition, the number of blood chemistry items in the NHNS varies and has tended to increase.…”

Section: Introductionmentioning

confidence: 99%

Revised System to Evaluate Measurement of Blood Chemistry Data From the Japanese National Health and Nutrition Survey and Prefectural Health and Nutrition Surveys

Nakamura

Kiyama

Kitamura

et al. 2013

Journal of Epidemiology

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BackgroundWe developed a monitoring system that uses total errors (TEs) to evaluate measurement of blood chemistry data from the National Health and Nutrition Survey (NHNS) and Prefectural Health and Nutrition Surveys (PHNS).MethodsBlood chemistry data from the NHNS and PHNS were analyzed by SRL, Inc., a commercial laboratory in Tokyo, Japan. Using accuracy and precision from external and internal quality controls, TEs were calculated for 14 blood chemistry items during the period 1999–2010. The acceptable range was defined as less than the upper 80% confidence limit for the median, the unacceptable range as more than twice the cut-off value of the acceptable range, and the borderline range as the interval between the acceptable and unacceptable ranges.ResultsThe TE upper limit for the acceptable and borderline ranges was 5.7% for total cholesterol (mg/dL), 9.9% for high-density lipoprotein cholesterol (mg/dL), 10.0% for low-density lipoprotein cholesterol (mg/dL), 10.4% for triglycerides (mg/dL), 6.6% for total protein (g/dL), 7.6% for albumin (g/dL), 10.8% for creatinine (mg/dL), 6.5% for glucose (mg/dL), 9.7% for γ-glutamyl transpeptidase (U/L), 7.7% for uric acid (mg/dL), 8.7% for urea nitrogen (mg/dL), 9.2% for aspartate aminotransferase (U/L), 9.5% for alanine aminotransferase (U/L), and 6.5% for hemoglobin A1c (%).ConclusionsThis monitoring system was established to assist health professionals in evaluating the continuity and comparability of NHNS and PHNS blood chemistry data among survey years and areas and to prevent biased or incorrect conclusions.

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“…changes on levels of some serum content including glutamic-pyruvic transaminase (GPT), aspartate aminotransferase (GOT), bilirubin, gamma glutamyltransferase (GGT), alkaline phosphatease (ALP) (Puhl et al, 2005;Tanne et al, 2005;Savransky et al, 2007aSavransky et al, , b, 2009. Therefore, the determination of those enzymes and substances was performed to evaluate the potential pathological changes of organisms (Nakamura et al, 2008). In this study, we employed Tibet Chicken, a unique native chicken breed inhabiting in Tibet altiplano with an average altitude above 3 000 m, and aimed to study the changes of fetal liver in hypoxia by determining the serum chemistry, compared with Shouguang chicken, an indigenous Chinese chicken breed in Shouguang county of Shandong province with an altitude less than 100 m, to explore the change patterns of the serum hepatic chemistry of the two chicken breeds in hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Effects of hypoxia on serum hepatic chemistries of Tibet chicken and Shouguang chicken

Han¹,

Song²,

Yuan³

et al. 2013

Afr. J. Biotechnol.

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Hypoxia is a major factor that affects the subsistence and development of multicellular organisms. Tibet chicken, as a unique native chicken breed in altiplano, shows genetic adaptation to hypoxia comparing with the breeds at the low altitude. In the present study, to explore effects of hypoxia on chicken fetal livers, eggs of Tibet chicken and Shouguang chicken were collected and the samples from each breed were divided into two groups, incubated in hypoxia and in normoxia respectively. The blood of embryos on the 16th day of incubation was collected and the serum chemistry parameters indicating liver metabolism were determined, which included glutamic-pyruvic transaminase (GPT), aspartate aminotransferase (GOT), total bilirubin (TB), direct bilirubin (DB), total bile acid (TBA), gamma glutamyltransferase (GGT), alkaline phosphatease (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), glucose and creatinine. The results show that biochemical indices varied significantly between hypoxia and normoxia except for GPT and glucose. Moreover, the concentration of ALP and LDH showed significant differences between the breeds and the incubations. The results suggest that the livers of both Shouguang chicken and Tibet chicken suffered damages in hypoxia, but the former was more serious. The results of this study support the opinion that Tibet chicken had better genetic adaptability on hypoxia, and made a good basis for further study of the genetic mechanism of adaptation to hypoxia.

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Establishment of Long-Term Monitoring System for Blood Chemistry Data by the National Health and Nutrition Survey in Japan

Abstract: Aim:We established a monitoring system for the annual follow-up of blood chemistry data obtained by the National Health and Nutrition Survey in Japan. Methods: Blood chemistry testing has been entrusted to SRL Inc. We used two external quality con-

Cited by 8 publications

References 8 publications

Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010

Associations between Socioeconomic Status and the Prevalence and Treatment of Hypercholesterolemia in a General Japanese Population: NIPPON DATA2010

Revised System to Evaluate Measurement of Blood Chemistry Data From the Japanese National Health and Nutrition Survey and Prefectural Health and Nutrition Surveys

Effects of hypoxia on serum hepatic chemistries of Tibet chicken and Shouguang chicken

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