Establishment of an in vitro evaluation system for drug-coated ballons

Abstract

Translation of the Bible or any other text unavoidably involves a determination about its meaning. There have been different views of meaning from ancient times up to the present, and a particularly Enlightenment and Modernist view is that the meaning of a text amounts to whatever the original author of the text intended it to be. This article analyzes the authorial-intent view of meaning in comparison with other models of literary and legal interpretation. Texts are anchors to interpretation but are subject to individualized interpretations. It is texts that are translated, not intentions. The challenge to the translator is to negotiate the meaning of a text and try to choose the most salient and appropriate interpretation as a basis for bringing the text to a new audience through translation.

Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases

“…In this study, although drug concentrations in the arterial tissues decreased with time, they were still detectable up to 2 weeks after delivery, leading to the reduction of neointimal proliferation efficiently. The past decade has witnessed extensive use of commercially available hydrogelcoated balloons to locally deliver drugs like paclitaxel 13 , heparin 46 , and argatroban 47 , among others. In our study, we observed that the hydrogel coatings showed significantly enhanced NP loading and more efficient NP transfer to the arterial wall compared to those of LbL and dip coatings.…”

“…Recent studies have revealed that it is challenging to produce a uniform and thin layer of hydrogel coating on the balloon, and our study also observed the non-uniform hydrogel coating. Kaule et al 13 highlighted the influence of the balloon coating structure (namely coating thickness) or the coating material on the performance of angioplasty balloons. This study observed reduced paclitaxel (PTX) loss, and superior PTX transfer in the case of balloons where the PTX was incorporated into a coating matrix of excipients such as cetylpyridinium salicylate (cetpyrsal) (18.94 μm thick) compared to hyaluronic acid (HA) (32.98 μm thick) and Polyvinylpyrrolidone (PVP) (34.11 μm).…”

“…Drug eluting balloons overcome these limitations as they do not cause any additional vessel trauma beyond the angioplasty procedure 3,13 . In addition, coating drugs onto the balloon surface allows combined angioplasty treatment and local drug delivery.…”