Establishment and Characterization of a Pluripotent Stem Cell line Derived from Human Amniotic Membranes and Initiation of Germ Layers in vitro

Tamagawa, Tomoharu; Ishiwata, Isamu; Saito, Shoji

doi:10.1111/j.1749-0774.2004.tb00028.x

Cited by 98 publications

(68 citation statements)

References 5 publications

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“…The suggestion that hAEC may be pluripotent is further supported by the report of Tamagawa et al (2004), whereby cells isolated from whole amnion were mixed with mouse embryonic stem cells, in order to create a xenogeneic chimera in vitro. This chimeric embryo was maintained until all three germ layers had formed, with demonstration that amnionderived cells had contributed to all three layers.…”

Section: Human Amniotic Epithelial Cellsmentioning

confidence: 75%

Placenta-derived stem cells: new hope for cell therapy?

2008

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An urgent current need in regenerative medicine is that of identifying a plentiful, safe and ethically acceptable stem cell source for the development of therapeutic strategies to restore functionality in damaged or diseased organs and tissues. In this context, human term placenta represents a prime candidate, as it is available in nearly unlimited supply, is ethically problem-free and easily procured. Placental cells display differentiation capacity toward all three germ layers, while also displaying immunomodulatory effects, therefore supporting the possibility that they could be applied in an allogeneic transplantation setting. Although promising data have been reported to date, further study is required to fully characterize the differentiation potential of placenta-derived cells and to identify their possible clinical applications. Here, we provide a snapshot of current knowledge regarding the potential of cells from the amniotic membrane of human term placenta to address current shortcomings in the field of regenerative medicine.

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Section: Human Amniotic Epithelial Cellsmentioning

confidence: 75%

Placenta-derived stem cells: new hope for cell therapy?

2008

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“…The suggestion that hAEC may be pluripotent was supported by the report by Tamagawa et al [15]. These investigators created a xenogeneic chimera of human amnion cells with mouse embryonic stem cells, in vitro.…”

Section: Fetal Placenta Tissue Cell Populations Human Amniotic Epithementioning

confidence: 97%

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

et al. 2007

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“…c-Kit and CD90 (Thy-1) expression is either negative or at a low level (Miki et al 2005;Miki & Strom 2006). However, evidence suggests that they express pluripotency markers and have the ability to form xenogeneic chimera with mouse ES cells in vitro (Tamagawa et al 2004). The cells have subsequently been differentiated in vitro into cell types from all three germ layers (Miki et al 2005;Miki & Strom 2006;Ilancheran et al 2007;Parolini et al 2008).…”

Section: Review Characteristics Of Stem Cells H Abdulrazzak Et Al mentioning

confidence: 99%

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Abdulrazzak

Moschidou

Jones

et al. 2010

J. R. Soc. Interface.

128

118

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Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these cells differ on many biological aspects such as growth kinetics, morphology, immunophenotype, differentiation potential and engraftment capacity in vivo. Despite these differences, FSCs appear to be more primitive and have greater multi-potentiality than their adult counterparts. For example, foetal blood haemopoietic stem cells proliferate more rapidly than those found in cord blood or adult bone marrow. These features have led to FSCs being investigated for pre-and post-natal cell therapy and regenerative medicine applications. The cells have been used in pre-clinical studies to treat a wide range of diseases such as skeletal dysplasia, diaphragmatic hernia and respiratory failure, white matter damage, renal pathologies as well as cancers. Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status.

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Establishment and Characterization of a Pluripotent Stem Cell line Derived from Human Amniotic Membranes and Initiation of Germ Layers in vitro

Abstract: This study demonstrates that human amniotic membranes derived stem cells have a wide developmental capability and might be utilized to regenerate different types of cells or tissues for transplantation therapy.

Cited by 98 publications

References 5 publications

Placenta-derived stem cells: new hope for cell therapy?

Placenta-derived stem cells: new hope for cell therapy?

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

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