Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic

Suliman, Noor Azuin; Taib, Che Norma Mat; Moklas, Mohamad Aris Mohd; Adenan, Mohd Ilham; Baharuldin, Mohamad Taufik Hidayat; Basir, Rusliza

doi:10.1155/2016/4391375

Cited by 66 publications

(53 citation statements)

References 124 publications

(137 reference statements)

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“…There are two types of nootropics: synthetic or natural compounds. While both have been widely researched and can effectively increase functions such as memory and attention, natural nootropics are associated with a safer side-effect profile and are even capable of making the brain healthier (see Suliman et al 2016).…”

Section: Introductionmentioning

confidence: 99%

A Combination of Nootropic Ingredients (CAF+) Is Not Better than Caffeine in Improving Cognitive Functions

et al. 2017

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Many nootropic compounds claim to have positive effects on cognitive performance. In this study, we tested the effects of the nootropic compound CAF+ on cognitive functioning. CAF+ contains a combination of ingredients that has separately shown to boost cognitive performance, including caffeine, l-theanine, vinpocetine, l-tyrosine, and vitamin B 6 /B 12 . We examined whether CAF+ would improve cognitive functions in healthy young participants, and whether it would be more effective than caffeine. We used a randomized double-blind placebo-controlled three-way cross-over design to examine the performance of 21 healthy young participants on a test battery aimed to measure memory performance, attention, and sensorimotor speed. Our main outcome measure was participant's performance on the Verbal Learning Test (VLT). Subjective alertness, heart rate, and blood pressure were also monitored. Participants were tested at 30 and 90 min after treatment. We found that after 90 min, the delayed recall performance on the VLT after caffeine was better than after CAF+ treatment. Further, caffeine, but not CAF+, improved the performance in a working memory task. In a complex choice reaction task caffeine improved the speed of responding. Subjective alertness was increased as a result of CAF+ at 30 min after administration. Only caffeine increased diastolic blood pressure. We conclude that in healthy young students, caffeine improves memory performance and sensorimotor speed, whereas CAF+ does not affect the cognitive performance at the dose tested.

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Section: Introductionmentioning

confidence: 99%

A Combination of Nootropic Ingredients (CAF+) Is Not Better than Caffeine in Improving Cognitive Functions

et al. 2017

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“…Piracetam exerts its action by enhancing cell membrane permeability and increase oxygen consumption by elevating the adenylate kinase activity in brain. 26,27 This drug is mainly used to treat a wide range of neurological abnormalities like seizures, epilepsy, myoclonus, dementia, myoclonus or Alzhemier's disease, multi infarct dementias, senile dementia, alcoholism, Parkinson's diseases etc. It has reported that piracetam produces neuro plasticity and it enhances memory and learning process thereby preventing lesions and ischemic damages.…”

Section: Discussionmentioning

confidence: 99%

Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model

Prabhu¹,

Prabhu²,

Chaudhuri³

et al. 2020

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“…As previously reported, pharmacological therapies have long been considered the best therapeutic option available for treating PD as the drug treatment has proved to be the one with the best results. Different herbal products have been evaluated throughout the years, and some have reached outstanding results such as M. pruriens , V. faba , Camelia sinensis , and G. biloba (Tanaka et al , ; Suliman et al , ).…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Herbal Extracts to Promote Behavioral and Neuroprotective Effects in Experimental Models of Parkinson's Disease: A Systematic Review

Costa

Cavalcanti

Queiróz

et al. 2017

Phytotherapy Research

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Parkinson's disease (PD) consists of a neurodegenerative pathology that has received a considerable amount of attention because of its clinical manifestations. The most common treatment consists of administering the drugs levodopa and biperiden, which reduce the effectiveness of the disease and the progress of its symptoms. However, phytotherapy treatment of PD has shown great potential in retarding the loss of dopaminergic neurons and minimizing the behavioral abnormalities. The aim of this study is to systematically review the use of supplemental herbal plants with cellular protective effect and behavioral activity in in vivo and in vitro experimental models. A total of 20 studies were summarized, where the effectiveness of herbal extracts and their isolated bioactive compounds was observed in animal models for PD. The main neurochemical mechanisms found in these studies are schematically represented. The herbal extracts and their biocompounds have antioxidant, anti-apoptotic, and antiinflammatory properties, which contribute to avoiding neuronal loss. Reports show that besides acting on the biosynthesis of dopamine and its metabolites, these compounds prevent D2 receptors' hypersensitivity. It is suggested that further studies need be conducted to better understand the mechanisms of action of the bioactive compounds distributed in these plants. Copyright © 2017 John Wiley & Sons, Ltd.

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Establishing Natural Nootropics: Recent Molecular Enhancement Influenced by Natural Nootropic

Cited by 66 publications

References 124 publications

A Combination of Nootropic Ingredients (CAF+) Is Not Better than Caffeine in Improving Cognitive Functions

A Combination of Nootropic Ingredients (CAF+) Is Not Better than Caffeine in Improving Cognitive Functions

Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model

Supplementation with Herbal Extracts to Promote Behavioral and Neuroprotective Effects in Experimental Models of Parkinson's Disease: A Systematic Review

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