Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement

Zanker, Jesse; Scott, David; Reijnierse, Esmee M.; Brennan-Olsen, Sharon; Daly, Robin M.; Girgis, Christian M.; Grossmann, Mathis; Hayes, Alan; Henwood, Timothy; Hirani, Vasant; Inderjeeth, Charles; Iuliano, Sandra; Keogh, Justin W L; Lewis, Josh; Maier, Andrea B.; Pasco, Julie A.; Phu, Steven; Sanders, Kerrie M.; Sim, Marc; Visvanathan, Renuka; Waters, Debra L.; Yu, Solomon; Duque, Gustavo

doi:10.1007/s12603-018-1113-6

Cited by 60 publications

(63 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The overall prevalence of confirmed sarcopenia was only 1%, suggests that the EWGSOP2 criteria are too conservative for sarcopenia case-finding in this population of community-dwelling Swedish 70-year-olds. This finding supports the need to validate sarcopenia definitions in population-specific settings and potentially to develop relevant local cut-points for low muscle mass and function [27].…”

Section: Conversely the Women's Health Initiative And Concord Healthsupporting

confidence: 69%

Associations of Sarcopenia and Its Components with Bone Structure and Incident Falls in Swedish Older Adults

et al. 2019

View full text Add to dashboard Cite

To compare bone structure parameters and likelihood of falls across European Working Group on Sarcopenia in Older People (EWGSOP2) sarcopenia categories. Methods: 3,334 Swedish 70-year-olds had appendicular lean mass (normalised to height; ALMHt), lumbar spine and total hip areal BMD (aBMD) estimated by dual-energy X-ray absorptiometry. Volumetric BMD (vBMD) and structure at the distal and proximal tibia and radius were estimated by peripheral quantitative computed tomography. Hand grip strength and time up-and-go were assessed, and sarcopenia was defined according to EWGSOP2 criteria. Incident falls were self-reported 6 and 12 months after baseline. Results: Only 0.8% and 1.0% of participants had probable and confirmed sarcopenia, respectively. Almost one-third of participants with confirmed sarcopenia reported incident falls, compared with 20% for probable sarcopenia and 14% without sarcopenia (P=0.025). Participants with confirmed sarcopenia had poorer bone parameters (all P<0.05) except endosteal circumference at the proximal radius and tibia, while those with probable sarcopenia had lower cortical area at the proximal radius (B=-5.9; 95% CI-11.7,-0.1 mm 2) and periosteal and endosteal circumferences at the proximal tibia (-3.3;-6.4,-0.3 and-3.8;-7.5,-0.05 mm 2 , respectively), compared with those without sarcopenia. Compared with probable sarcopenia, confirmed sarcopenic participants had significantly lower lumbar spine and total hip aBMD, distal radius and tibia total vBMD, and proximal radius and tibia cortical vBMD, area and thickness (all P<0.05). Conclusions: Swedish 70-year-olds with confirmed sarcopenia demonstrate poorer BMD and bone architecture than those with probable and no sarcopenia, and have increased likelihood of incident falls.

show abstract

Section: Conversely the Women's Health Initiative And Concord Healthsupporting

confidence: 69%

Associations of Sarcopenia and Its Components with Bone Structure and Incident Falls in Swedish Older Adults

et al. 2019

View full text Add to dashboard Cite

show abstract

“…18,25 Sarcopenia was deemed present if an individual had both low HGS and low ALM/height 2 or slow TUG/gait speed, or low HGS and low ALM/BMI (FNIH). 3,4,16,25 The criteria were presented as (i) low HGS + low ALM/height 2 for EWGSOP1 or EWGSOP2 or (ii) low HGS + slow TUG/gait speed for EWGSOP1, and (iii) low HGS + low ALM/BMI for FNIH. EWGSOP suggests using ALM adjusted for height 2 , while FNIH recommends using ALM adjusted for BMI.…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently, the importance of muscle strength and performance in association with health outcomes in the elderly led to a change in the definition for sarcopenia to consider low muscle mass in combination with either low grip strength or low gait speed. 1,3,4,7,15,16 There is further confusion regarding inconsistencies in the thresholds applied to identify low muscle mass, muscle strength, and muscle function.…”

Section: Introductionmentioning

confidence: 99%

Definition‐specific prevalence estimates for sarcopenia in an Australian population: the Geelong Osteoporosis Study

Sui

Holloway‐Kew

Hyde

et al. 2020

JCSM Clinical Reports

View full text Add to dashboard Cite

BackgroundWe aimed to compare prevalence estimates for sarcopenia in an Australian sample of older men and women by using different criteria.MethodsWomen (n = 323) and men (n = 342) aged 60–96 years from the Geelong Osteoporosis Study were included. Handgrip strength (HGS) was measured by dynamometer (Jamar or Vernier) and appendicular lean mass (ALM) by whole‐body densitometry (Lunar). Sarcopenia definitions included European Working Group on Sarcopenia in Older People (EWGSOP) 1, EWGSOP2, and US Foundation for the National Institutes of Health (FNIH). Sarcopenia was identified as low HGS and low ALM/height2 or low muscle performance, and low HGS and low ALM/body mass index (BMI). Prevalence estimates were standardized to the Australian population and agreement between definitions assessed using the Cohen kappa statistic (κ).ResultsLow HGS was identified in 13.7–29.9% of women and 2.1–14.1% of men. Low ALM/height2 was identified in 7.1–11.8% of women and 6.0–8.4% of men, while 21.7% of women and 21.1% of men had low ALM/BMI. Mean age‐standardized prevalence estimates for sarcopenia were 5.9% (95% confidence interval 3.4–8.4) for women and 2.9% (1.9–4.0) for men (EWGSOP1), 2.3% (1.1–3.4) for women and 0.5% (0.2–0.9) for men (EWGSOP2), and 4.0% (2.1–5.8) for women and 1.1% (0.6–1.5) for men (FNIH). There was moderate agreement between EWGSOP1 and EWGSOP2 (κ = 0.58 women, 0.30 men) and poor agreement between FNIH and EWGSOP1 (κ = 0.16 women, 0.12 men) and EWGSOP2 (κ = 0.19 women, 0 men).ConclusionsSarcopenia prevalence differed according to definition applied. Point estimates for sarcopenia prevalence according to EWGSOP2 identified fewer individuals than EWGSOP1, with FNIH estimates between the two; however, there were overlapping 95% confidence intervals across definitions.

show abstract

“…Muscle weakness is a predictor for falls [4], falls-related hospitalisation [5], fractures [6], comorbidities such as the metabolic syndrome [7] and all-cause mortality [8]. Weakness is one of five physical characteristics considered by Fried et al [9] to support a diagnosis of frailty, and low muscle strength is a key component of sarcopenia [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Lower-limb muscle strength: normative data from an observational population-based study

Pasco

Stuart

Holloway‐Kew

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: The extent of muscle deterioration associated with ageing or disease can be quantified by comparison with appropriate reference data. The objective of this study is to present normative data for lower-limb muscle strength and quality for 573 males and 923 females aged 20-97 yr participating in the Geelong Osteoporosis Study in southeastern Australia. Methods: In this cross-sectional study, measures of muscle strength for hip flexors and hip abductors were obtained using a Nicholas manual muscle tester, a hand-held dynamometer (HHD; kg). Leg lean mass was measured by dual energy x-ray absorptiometry (DXA; kg), and muscle quality calculated as strength/mass (N/kg). Results: For both sexes, muscle strength and quality decreased with advancing age. Age explained 12.9-25.3% of the variance in muscle strength in males, and 20.8-24.6% in females; age explained less of the variance in muscle quality. Means and standard deviations for muscle strength and quality for each muscle group are reported by agedecade for each sex, and cutpoints equivalent to T-scores of − 2.0 and − 1.0 were derived using data from young males (n = 89) and females (n = 148) aged 20-39 years. Conclusions: These data will be useful for quantifying the extent of dynapenia and poor muscle quality among adults in the general population in the face of frailty, sarcopenia and other age-related muscle dysfunction.

show abstract

Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement

Abstract: Conclusion With consensus achieved, the ANZSSFR will adopt, promote and validate the EWGSOP operational definition of sarcopenia for use by clinicians and researchers in Australia and New Zealand.

Cited by 60 publications

References 25 publications

Associations of Sarcopenia and Its Components with Bone Structure and Incident Falls in Swedish Older Adults

Associations of Sarcopenia and Its Components with Bone Structure and Incident Falls in Swedish Older Adults

Definition‐specific prevalence estimates for sarcopenia in an Australian population: the Geelong Osteoporosis Study

Lower-limb muscle strength: normative data from an observational population-based study

Contact Info

Product

Resources

About