Abstract:Oncocardiology is an emerging field in cardiovascular healthcare. Besides establishing surveillance and follow-up strategies for cancer patients, it will be essential to set up specialized oncocardiology services. However, there is a lack of clinical studies to give evidence-based recommendations regarding cardiological diagnostic and therapeutic approaches for cancer patients. An oncocardiology service is a patient-centered structure that aims to integrate research and interdisciplinary patient care to bridge… Show more
“…Cardio-oncology units are essential for the assessment of cardiovascular function, including the standardised evaluation of diastolic function in cancer patients [57][58][59]. Through the serial and standardised evaluation of diastolic function in cardio-oncology units, together with the use of novel parameters e.g.…”
Background: Anthracycline-based chemotherapy (ANT) remains among the most effective therapies for breast cancer. Cardiotoxicity from ANT represents a severe adverse event and may predominantly manifest as heart failure. While it is well-recognised that left ventricular systolic heart failure assessment is key in ANT-treated patients, less is known about the relevance of LV diastolic functional impairment and its characterisation. Methods: Studies reporting on echocardiographic diastolic function parameters before and after ANT in breast cancer patients without cardiac disease were included. We evaluated pulsed wave (E/A ratio and mitral E-wave deceleration time (EDT)) and tissue Doppler (mean velocities of the mitral ring in the early diastole (e′) and E/e′ ratio) echocardiographic parameters. Results: A total of 892 patients from 13 studies were included. E/A ratio was significantly reduced at the end of ANT while EDT was not influenced by ANT. Additionally, e’ and E/e’ ratio showed no significant change after ANT. A modest reduction in LV ejection fraction and global longitudinal strain was observed at the end of ANT therapy. Conclusions: ANT had a modest early impact on E/A ratio, without changing EDT, e’, or E/e’ in patients with breast cancer without cardiac disease. Randomised studies on larger populations, using new parameters are required to define the role of diastolic dysfunction in the early diagnosis of ANT-induced cardiotoxicity.
“…Cardio-oncology units are essential for the assessment of cardiovascular function, including the standardised evaluation of diastolic function in cancer patients [57][58][59]. Through the serial and standardised evaluation of diastolic function in cardio-oncology units, together with the use of novel parameters e.g.…”
Background: Anthracycline-based chemotherapy (ANT) remains among the most effective therapies for breast cancer. Cardiotoxicity from ANT represents a severe adverse event and may predominantly manifest as heart failure. While it is well-recognised that left ventricular systolic heart failure assessment is key in ANT-treated patients, less is known about the relevance of LV diastolic functional impairment and its characterisation. Methods: Studies reporting on echocardiographic diastolic function parameters before and after ANT in breast cancer patients without cardiac disease were included. We evaluated pulsed wave (E/A ratio and mitral E-wave deceleration time (EDT)) and tissue Doppler (mean velocities of the mitral ring in the early diastole (e′) and E/e′ ratio) echocardiographic parameters. Results: A total of 892 patients from 13 studies were included. E/A ratio was significantly reduced at the end of ANT while EDT was not influenced by ANT. Additionally, e’ and E/e’ ratio showed no significant change after ANT. A modest reduction in LV ejection fraction and global longitudinal strain was observed at the end of ANT therapy. Conclusions: ANT had a modest early impact on E/A ratio, without changing EDT, e’, or E/e’ in patients with breast cancer without cardiac disease. Randomised studies on larger populations, using new parameters are required to define the role of diastolic dysfunction in the early diagnosis of ANT-induced cardiotoxicity.
“…Research indicates that multidisciplinary teams improve patient health outcomes and adherence to guidelines [16]. These advancements, along with evolv-ing modalities in cardio-oncology, contribute to improving survival rates among cancer patients, with the specialty primarily aimed at facilitating successful cancer treatments and reducing the burden of cardiovascular diseases [17]. This approach aims to ultimately decrease cardiovascular morbidity and mortality among the increasing population of cancer patients and survivors [18].…”
Section: A Classic Cardio-oncology Setup In Lmicmentioning
There have been considerable advancements in cancer therapy in recent years. However, adverse effects often defeat the benefits, especially on the cardiovascular system. The effects of chemotherapeutic agents on the cardiovascular system can be directly on the heart by altering the coagulability state or by altering the hemodynamic system. Some drugs like Sunitinib and Bevacizumab show Heart Failure which is chemotherapy-induced. Other agents are notorious for showing QT prolongation like Vandetanib. Similarly, other agents with demonstrated cardiotoxicity would be molecular-targeted drugs (Trastuzumab and Pertuzumab) and cytostatic agents (Anthracycline How to cite this paper: Dhal, A.
“…Own studies are focused on phenotyping of certain cohorts and integration of different data sets (among others, PET-CT scans, biomarkers and cMRI) [8]. At our unit, especially checkpoint inhibitor-associated myocarditis is a [10]). hs-cTnT high-sensitive cardiac troponin t, ACEi Angiotensin-convertingenzyme inhibitor, ECG electrocardiogram, CAD coronary artery disease major focus of clinical research and part of international collaborations [9].…”
Section: Sirsmentioning
confidence: 99%
“…Most importantly, the communication with the oncologist is crucial to achieve the best outcome for the patient. In the initial phase, the interaction between oncologists and cardiologists has intensified by participation in tumor boards and repeated presentations of cardio-oncological topics, but further referral and treatment strategies have to be developed and validated [10].…”
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