Left Ventricular Diastolic Function Following Anthracycline-Based Chemotherapy in Patients with Breast Cancer without Previous Cardiac Disease—A Meta-Analysis

Mincu, Raluca I; Lampe, Lena; Mahabadi, Amir A.; Rassaf, Tienush; Totzeck, Matthias

doi:10.3390/jcm10173890

Cited by 16 publications

(8 citation statements)

References 58 publications

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“…The diastolic dysfunction was shown to occur as early as 2 days after Dox injection in a rat model [ 65 ]. However, a recent meta-analysis showed that anthracycline-chemotherapy in breast cancer patients without previous cardiac disease had a modest early impact on E/A and E/E’ ratios [ 66 ]. Increased levels of left ventricular fibrosis as early as 3 days after Dox treatment in our previous studies [ 3 ] warrant further studies on the impact of Dox on diastolic function by measuring mitral valve inflow patterns and tissue doppler velocities at the lateral annulus of the mitral valve.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury

Baguma-Nibasheka

Feridooni

Zhang

et al. 2021

Cells

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There is no effective treatment for the total recovery of myocardial injury caused by an anticancer drug, doxorubicin (Dox). In this study, using a Dox-induced cardiac injury model, we compared the cardioprotective effects of ventricular cells harvested from 11.5-day old embryonic mice (E11.5) with those from E14.5 embryos. Our results indicate that tail-vein-infused E11.5 ventricular cells are more efficient at homing into the injured adult myocardium, and are more angiogenic, than E14.5 ventricular cells. In addition, E11.5 cells were shown to mitigate the cardiomyopathic effects of Dox. In vitro, E11.5 ventricular cells were more migratory than E14.5 cells, and RT-qPCR analysis revealed that they express significantly higher levels of cytokine receptors Fgfr1, Fgfr2, Pdgfra, Pdgfrb and Kit. Remarkably, mRNA levels for Fgf1, Fgf2, Pdgfa and Pdgfb were also found to be elevated in the Dox-injured adult heart, as were the FGF1 and PDGFB protein levels. Addition of exogenous FGF1 or PDGFB was able to enhance E11.5 ventricular cell migration in vitro, and, whereas their neutralizing antibodies decreased cell migration. These results indicate that therapies raising the levels of FGF1 and PDGFB receptors in donor cells and or corresponding ligands in an injured heart could improve the efficacy of cell-based interventions for myocardial repair.

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Section: Discussionmentioning

confidence: 99%

Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury

Baguma-Nibasheka

Feridooni

Zhang

et al. 2021

Cells

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“…In the previous work, data indicated a cohort of premenopausal women diagnosed with hormone receptor-positive breast cancer undergoing near-complete estrogen deprivation therapy exhibited short-term increases in global longitudinal and radial modulus values of ∼40%, which was significantly greater than changes in elasticity in a comparator cohort of premenopausal patients. We also expect changes in stiffness due to anthracycline therapy to be larger with evidence showing significant myocardial stiffness modulation due to chemotherapies, 34 indicating our methodology is capable of indicating changes in LV stiffness as a results of cardiotoxic antineoplastic therapies. Our results also define a threshold of significance to differentiate biological changes in modulus from methodological variability, important for potential future clinical implementation when assessing individual elasticity measurements.…”

Section: Discussionmentioning

confidence: 92%

Reproducibility assessment of a biomechanical model-based elasticity imaging method for identifying changes in left ventricular mechanical stiffness

et al. 2022

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. Purpose Cardiotoxicity of antineoplastic therapies is increasingly a risk to cancer patients treated with curative intent with years of life to protect. Studies highlight the importance of identifying early cardiac decline in cancer patients undergoing cardiotoxic therapies. Accurate tools to study this are a critical clinical need. Current and emerging methods for assessing cardiotoxicity are too coarse for identifying preclinical cardiac degradation or too cumbersome for clinical implementation. Approach In the previous work, we developed a noninvasive biomechanical model-based elasticity imaging methodology (BEIM) to assess mechanical stiffness changes of the left ventricle (LV) based on routine cine cardiac magnetic resonance (CMR) images. We examine this methodology to assess methodological reproducibility. We assessed a cohort of 10 participants that underwent test/retest short-axis CMR imaging at baseline and follow-up sessions as part of a previous publicly available study. We compare test images to retest images acquired within the same session to assess within-session reproducibility. We also compare test and retest images acquired at the baseline imaging session to test and retest images acquired at the follow-up imaging session to assess between-session reproducibility. Results We establish the within-session and between-session reproducibility of our method, with global elasticity demonstrating repeatability within a range previously demonstrated in cardiac strain imaging studies. We demonstrate increased repeatability of global elasticity compared to segmental elasticity for both within-session and between-session. Within-subject coefficients of variation for within-session test/retest images globally for all modulus directions and a mechanical fractional mechanical stiffness anisotropy metric ranged from 11% to 28%. Conclusions Results suggest that our methodology can reproducibly generate estimates of relative mechanical elasticity of the LV and provides a threshold for distinguishing true changes in myocardial mechanical stiffness from experimental variation. BEIM has applications in identifying preclinical cardiotoxicity in breast cancer patients undergoing antineoplastic therapies.

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“…Mincu et al used echocardiography to detect heart failure. The evaluation of left ventricular systolic heart failure is recognized as the key to treating patients; thus, Mincu specifically evaluates left ventricular diastolic dysfunction [ 34 ]. The pulse wave in this study was mainly used to evaluate the traditional left ventricular contractility.…”

Section: Discussionmentioning

confidence: 99%

Radial arterial waves for chemotherapy- and radiotherapy-related myocardial damage identification in patients with breast cancer

Lee¹,

Yen²,

Hou³

et al. 2023

BioMedicine

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Summary Introduction Chemotherapy and radiation therapy for breast cancer cause side effects, such as cardiovascular changes, which can be monitored with echocardiography. However, more convenient methods are always encouraged. Radial arterial waves that are used to detect cardiovascular changes can be used to assist in confirming cardiovascular changes. Aim This retrospective study aimed to analyze the frequency and time domains of the radial artery pulse wave in patients with breast cancer to understand its effectiveness in identifying cardiovascular changes. Methods Patients with breast cancer were screened from the pulse examination records in Changhua Christian Hospital and divided into the treatment and remission groups. After unlinking the data, the pulse data were analyzed for the breast cancer treatment and remission group, including the average value of the parameters of four consecutive pulse diagnosis records in four consecutive months to test the difference in pulse waves due to breast cancer treatment between the two groups. Additionally, the pulse wave stability of the two groups was compared using the coefficient of variation. Results and conclusion The comparison of the pulse wave data between 19 patients in the treatment group and 40 patients in the remission group revealed 45 parameters in time and 50 in frequency domains. D3, ND3, NA1, and NT1 are the four parameters with significant differences (p < 0.05), which are all related to heart function, and mainly related to cardiac output and peripheral resistance, indicating that patients in the treatment period have poor heart function. No difference was found in the degree of data dispersion between the two groups. Cardiovascular side effects caused by breast cancer treatment can mainly be shown in the pulse wave time domain.

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Left Ventricular Diastolic Function Following Anthracycline-Based Chemotherapy in Patients with Breast Cancer without Previous Cardiac Disease—A Meta-Analysis

Cited by 16 publications

References 58 publications

Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury

Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury

Reproducibility assessment of a biomechanical model-based elasticity imaging method for identifying changes in left ventricular mechanical stiffness

Radial arterial waves for chemotherapy- and radiotherapy-related myocardial damage identification in patients with breast cancer

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