Established and potential echocardiographic markers of embolism and their therapeutic implications in patients with ischemic stroke

Gąsiorek, Paulina; Banach, Maciej; Maciejewski, Marek; Głąbiński, Andrzej; Paduszyńska, Aleksandra; Rysz, Jacek; Bielecka‐Dąbrowa, Agata

doi:10.5603/cj.a2018.0046

Cited by 6 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, novel screening methods such as prolonged recording devices (e.g., loop recorders), blood markers (e.g., pro-BNP), and electrocardiographic and imaging markers have increased the prevalence of cardioembolic strokes. [11][12][13][14] While many of the risk factors for ischemic strokes may be modifiable and/or potentially modifiable, non-modifiable risk factors pose a special problem. Weather has long been considered a factor that affects stroke risk variously.…”

Section: Discussionmentioning

confidence: 99%

Does Inclement Weather Increase the Risk of Cardioembolic Stroke in Kashmir Valley?

Dar,

Wani,

Yaqoob

et al. 2024

Journal of Stroke Medicine

View full text Add to dashboard Cite

Background: Cardioembolic strokes are a common cause of mortality and morbidity because they are usually big and multiple. Despite extensive advances in the determination and management of modifiable risk factors of these strokes, a significant proportion are attributed to non-modifiable factors. We wanted to test the hypothesis that cardioembolic strokes and no other subtypes of ischemic stroke are associated with inclement weather in Kashmir Valley where winter seasons have harsh weather. Results: A total of 540 ischemic stroke patients were included in the study of which cardioembolic strokes were most common. Cardioembolic strokes were more common in the winter season and associated with lower minimum and maximum temperatures. Conclusion: Evaluation and management of cardioembolic strokes during winter months may demand more attention, particularly in elderly individuals and those with risk factors for atrial fibrillation.

show abstract

Section: Discussionmentioning

confidence: 99%

Does Inclement Weather Increase the Risk of Cardioembolic Stroke in Kashmir Valley?

Dar,

Wani,

Yaqoob

et al. 2024

Journal of Stroke Medicine

View full text Add to dashboard Cite

show abstract

“…Approximately one-fourth of all strokes are ESUS. Identification of the prognostic factors is necessary in order to optimize the preventive strategy [6]. The presence of ESUS strokes indicates that the conventional risk factors cannot fully account for the pathogenesis of stroke.…”

Section: Introductionmentioning

confidence: 99%

Arterial Stiffness and Indices of Left Ventricular Diastolic Dysfunction in Patients with Embolic Stroke of Undetermined Etiology

et al. 2019

Self Cite

View full text Add to dashboard Cite

Purpose. The study is aimed at identifying echocardiographic and circulating biomarkers as well as hemodynamic indices of embolic stroke of undetermined etiology (ESUS) in patients aged <65. Methods. We prospectively investigated 520 patients with confirmed ischemic stroke and selected those 65 patients who were diagnosed with ESUS (age 54 (47-58) years, 42% male). An additional 36 without stroke but with a similar risk profile were included as a control group (age 53 (47-58) years, 61% male). All patients underwent echocardiography, noninvasive assessment of hemodynamic parameters using a SphygmoCor tonometer (AtCor Med., Australia), and measurements of selected biomarkers. Results. ESUS patients and controls were well matched for baseline characteristics including blood pressure and left ventricular ejection fraction (LVEF). Compared to controls, patients with ESUS had lower mean early diastolic (E′) and systolic (S′) mitral annular velocities and a higher ratio of the peak velocity of early diastolic transmitral flow to the peak velocity of early diastolic mitral annular motion (all p<0.01). The peak velocity flow in the late diastole (A wave) value and LV mass indexed to the body surface area (LVMI) (g/m2) were higher in the ESUS group than in the control group (both p<0.01). The isovolumetric relaxation time (IVRT) was longer and the mean left atrial volume index (LAVI) was higher in ESUS patients compared to the control group. Parameters of arterial stiffness such as augmentation pressure, augmentation index, and augmentation index adjusted to a heart rate of 75 bpm (AIx75) were higher in ESUS patients compared to controls (p<0.05). Patients in the ESUS group had higher levels of asymmetric dimethylarginine, interleukin 6, and N-terminal probrain natriuretic peptide (NT-proBNP, all p<0.05) than those in the control group. In multivariate analysis, the following factors were significantly associated with the presence of ESUS: AIx75 (odds ratio (OR) 1.095, 95% confidence interval (CI) 1.004-1.194; p=0.04), IVRT (OR 1.045, 95% CI: 1.009-1.082; p=0.014), LAVI (OR 1.3, 95% CI: 1.099-1.537; p=0.002), and NT-proBNP (OR 1.003, 95% CI: 1.001-1.005; p=0.005). Conclusions. Increased arterial stiffness and indices of diastolic dysfunction as well as a higher NT-proBNP level are significantly associated with ESUS. These parameters require further scrutiny over time to understand their impact on the development of symptomatic heart failure. The ClinicalTrials.gov identifier is NCT03377465.

show abstract

Carotid Sinus Syndrome

Kasperowicz

Banach

Maciejewski

et al. 2019

Hypotensive Syndromes in Geriatric Patients

View full text Add to dashboard Cite

Established and potential echocardiographic markers of embolism and their therapeutic implications in patients with ischemic stroke

Cited by 6 publications

References 54 publications

Does Inclement Weather Increase the Risk of Cardioembolic Stroke in Kashmir Valley?

Does Inclement Weather Increase the Risk of Cardioembolic Stroke in Kashmir Valley?

Arterial Stiffness and Indices of Left Ventricular Diastolic Dysfunction in Patients with Embolic Stroke of Undetermined Etiology

Carotid Sinus Syndrome

Contact Info

Product

Resources

About