Arterial Stiffness and Indices of Left Ventricular Diastolic Dysfunction in Patients with Embolic Stroke of Undetermined Etiology

Abstract

Purpose. The study is aimed at identifying echocardiographic and circulating biomarkers as well as hemodynamic indices of embolic stroke of undetermined etiology (ESUS) in patients aged <65. Methods. We prospectively investigated 520 patients with confirmed ischemic stroke and selected those 65 patients who were diagnosed with ESUS (age 54 (47-58) years, 42% male). An additional 36 without stroke but with a similar risk profile were included as a control group (age 53 (47-58) years, 61% male). All patients underwent echocardiography, noninvasive assessment of hemodynamic parameters using a SphygmoCor tonometer (AtCor Med., Australia), and measurements of selected biomarkers. Results. ESUS patients and controls were well matched for baseline characteristics including blood pressure and left ventricular ejection fraction (LVEF). Compared to controls, patients with ESUS had lower mean early diastolic (E′) and systolic (S′) mitral annular velocities and a higher ratio of the peak velocity of early diastolic transmitral flow to the peak velocity of early diastolic mitral annular motion (all p<0.01). The peak velocity flow in the late diastole (A wave) value and LV mass indexed to the body surface area (LVMI) (g/m2) were higher in the ESUS group than in the control group (both p<0.01). The isovolumetric relaxation time (IVRT) was longer and the mean left atrial volume index (LAVI) was higher in ESUS patients compared to the control group. Parameters of arterial stiffness such as augmentation pressure, augmentation index, and augmentation index adjusted to a heart rate of 75 bpm (AIx75) were higher in ESUS patients compared to controls (p<0.05). Patients in the ESUS group had higher levels of asymmetric dimethylarginine, interleukin 6, and N-terminal probrain natriuretic peptide (NT-proBNP, all p<0.05) than those in the control group. In multivariate analysis, the following factors were significantly associated with the presence of ESUS: AIx75 (odds ratio (OR) 1.095, 95% confidence interval (CI) 1.004-1.194; p=0.04), IVRT (OR 1.045, 95% CI: 1.009-1.082; p=0.014), LAVI (OR 1.3, 95% CI: 1.099-1.537; p=0.002), and NT-proBNP (OR 1.003, 95% CI: 1.001-1.005; p=0.005). Conclusions. Increased arterial stiffness and indices of diastolic dysfunction as well as a higher NT-proBNP level are significantly associated with ESUS. These parameters require further scrutiny over time to understand their impact on the development of symptomatic heart failure. The ClinicalTrials.gov identifier is NCT03377465.

Left ventricular diastolic dysfunction is associated with cerebral infarction in young hypertensive patients: A retrospective case‑control study

“…The reason why LVD dysfunction induces abnormal peripheral hemodynamics followed by cerebral hypoperfusion has yet to be identified. First, we surmise that with decreasing diastolic function, the left ventricle cannot effectively expand, causing the returned blood volume and cerebral perfusion blood to decrease (27). Second, the decreased LVD function leads to a decrease in blood flow and friction between the endothelia of blood vessels, atherosclerosis is promoted, acute cerebrovascular occlusion is created and CI ultimately occurs (28).…”

Prevalence of markers of atrial cardiomyopathy in embolic stroke of undetermined source: A systematic review

“…Of the remaining studies, 7 were excluded after full text screening. Eventually, 11 studies satisfied the eligibility criteria and their quality was assessed [17][18][19][20][21][22][23][24][25][26][27]. All eligible studies were observational and written in English.…”

Embolic Stroke of Undetermined Source: Approaches in Risk Stratification for Cardioembolism

“…96 Further, it is 3× as prevalent in the ESUS population compared with those with noncardioembolic stroke, 94 with several echocardiographic markers of LVDD (including isovolumetric relaxation time, early diastolic and systolic mitral annular velocities, and E/e′) having strong associations with ESUS subtypes. 97 E/e′ has also been found to be an independent predictor of recurrent stroke and mortality in this population. 98 One explanation for this association may be due to its impact on adverse LA remodelling and development of AF, 99 both factors associated with cardioembolism.…”