Essiac® and Flor-Essence® herbal tonics stimulate the in vitro growth of human breast cancer cells

Kulp, Kristen S.; Montgomery, Jenny; Nelson, David; Cutter, Beth; Latham, Eugene; Shattuck, David L.; Klotz, Diane M.; Bennett, Lee

doi:10.1007/s10549-005-9156-x

Cited by 16 publications

(17 citation statements)

References 62 publications

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“…To date, no prospective clinical trial using Essiac in humans has been reported. On the other hand, Essiac stimulated growth of human breast cancer cells both via estrogen receptor (ER) dependent and ER independent pathways [65]. In this regard, breast cancer patients should avoid the use of Essiac.…”

Section: Essiacmentioning

confidence: 99%

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

Yang

Liu

et al. 2010

CMC

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A large number of herbal remedies (e.g. garlic, mistletoe, Essiac, Lingzhi, and astragalus) are used by cancer patients for treating the cancer and/or reducing the toxicities of chemotherapeutic drugs. Some herbal medicines have shown potentially beneficial effects on cancer progression and may ameliorate chemotherapy-induced toxicities. However, there is no or weak scientific basis for the clinical use of these herbal medicines in cancer management and almost none of these plant medicines have been tested in rigorous clinical trials. There are increased reports on the interaction of herbal medicines and anticancer drugs that is becoming a safety concern. For example, a clinical study in cancer patients reported that treatment of St John's wort at 900 mg/day orally for 18 days decreased the plasma levels of the active metabolite of irinotecan, SN-38, by 42%. In healthy subjects, 2 weeks of treatment with St John's wort at 900 mg/day significantly decreased the systemic exposure of imatinib by 32%. In women with advanced breast cancer, coadministration of garlic supplement reduced the clearance of docetaxol by 23.1-35.1%, although the difference did not achieve statistical significance. Most anticancer drugs undergo Phase I and/or II metabolism and are substrates of P-glycoprotein, breast cancer resistance protein, multidrug resistance associated proteins, and/or other transporters. Induction and inhibition of these enzymes and transporters is considered an important mechanism for herb-anticancer drug interactions. Further studies are warranted to investigate potentially harmful herbal interactions with anticancer drugs in patients.

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Section: Essiacmentioning

confidence: 99%

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

Yang

Liu

et al. 2010

CMC

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“…A widely used herbal extract formulation (Essiac®) has been commercially produced and it is widely used as a complementary and alternative medicine (CAM) by some cancer patients and survivors (Kulp et al, 2006). These four plants were reported to have hepatoprotective, antiinflammatory (A. lappa, R. palmatum), strong antioxidant and free radical scavenging (A. lappa), gastroprotective (R. palmatum, U. rubra), and anti-septic and anti-spasmodic (R. palmatum) activities (Bradley, 1992;Lin, Lin, Yang, Chuang, & Ujiie, 1996;Duh, 1998;Tamayo, Richardson, Diamond, & Skoda, 2000;Lin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Anti-leukemic activity of a four-plant mixture in a leukemic rat model

Kabeel

Ghoneim

Mansy

2018

JoBAZ

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“…Nowadays, both the underground parts and aerial parts of some docks, e.g. R. acetosa, R. acetosella, R. confertus, R. crispus, R. hydrolapathum and R. obtusifolius are commonly used in different kind of diseases treatments [2][3][4]. Preparations from the Rumex, especially due to their anti-inflammatory and antimicrobial activities, are useful in dermatology for skin infections [5][6][7][8][9], in inflammation of the gastrointestinal tract and digestive disorders [5,7,10,11], as laxative or antidiarrheal agents [7,[11][12][13][14] and as a treatment for upper respiratory tract diseases (nasal sinuses and throat) [15].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the extracts from fruits of Rumex L. species

et al. 2011

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This study was designed primarily to investigate the antibacterial and antifungal activity of the extracts from fruits of six Rumex L. species: R. acetosa L., R. acetosella L., R. confertus Willd., R. crispus L., R. hydrolapathum Huds. and R. obtusifolius L. The 7 Grampositive and 7 Gram-negative bacteria strains and 5 fungal ones were tested by agar and broth dilution method. Determination of minimal inhibitory concentration (MIC) revealed that the extracts from R. confertus, R. crispus, R. hydrolapathum and R. obtusifolius exerted differential inhibitory effect on the growth of Gram-positive bacteria — staphylococci (MIC=62.5–125 µg/mL) and Gramnegative bacteria — Escherichia coli ATCC 3521, Proteus mirabilis, Pseudomonas aeruginosa (MIC=125→500 µg/mL); MIC values determined by agar dilution method were somewhat higher. The same extracts inhibited also the growth of fungi — Candida spp. or Trichophyton mentagrophytes ATCC 9533 (MIC=250–500 µg/mL), as found by agar dilution method. The total content of polyphenols (11.66–78.36 mg/g), anthracene derivatives (0.26–12.93 mg/g) and tannins (4.00–11.16%) was also determined.

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Essiac® and Flor-Essence® herbal tonics stimulate the in vitro growth of human breast cancer cells

Abstract: Flor-Essence and Essiac Herbal Tonics can stimulate the growth of human breast cancer cells through ER mediated as well as ER independent mechanisms of action.

Cited by 16 publications

References 62 publications

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

Anti-leukemic activity of a four-plant mixture in a leukemic rat model

Antimicrobial activity of the extracts from fruits of Rumex L. species

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