Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages

Glik, Amir; Masarwa, Magdalena; Abuful, Amin; Deeb, Amar; Strugatsky, Rosa; Farrer, Lindsay A.; Friedland, Robert P.; Inzelberg, Rivka

doi:10.1002/mds.22324

Cited by 26 publications

(29 citation statements)

References 31 publications

(37 reference statements)

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“…This work is part of an epidemiological study of aging-related brain disorders in Wadi Ara [21-23]. The elderly cohort (aged ≥65 years) included 2,067 residents (2.5%) on prevalence day, according to the Israel Central Bureau of Statistics.…”

Section: Methodsmentioning

confidence: 99%

Prayer at Midlife is Associated with Reduced Risk of Cognitive Decline in Arabic Women

Inzelberg

Afgin²,

Massarwa³

et al. 2013

CAR

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Midlife habits may be important for the later development of Alzheimer's disease (AD). We estimated the contribution of midlife prayer to the development of cognitive decline. In a door-to-door survey, residents aged ≥65 years were systematically evaluated in Arabic including medical history, neurological, cognitive examination, and a midlife leisure-activities questionnaire. Praying was assessed by the number of monthly praying hours at midlife. Stepwise logistic regression models were used to evaluate the effect of prayer on the odds of mild cognitive impairment (MCI) and AD versus cognitively normal individuals. Of 935 individuals that were approached, 778 [normal controls (n=448), AD (n=92) and MCI (n=238)] were evaluated. A higher proportion of cognitively normal individuals engaged in prayer at midlife [(87%) versus MCI (71%) or AD (69%) (p<0.0001)]. Since 94% of males engaged in prayer, the effect on cognitive decline could not be assessed in men. Among women, stepwise logistic regression adjusted for age and education, showed that prayer was significantly associated with reduced risk of MCI (p=0.027, OR=0.55, 95% CI 0.33-0.94), but not AD. Among individuals endorsing prayer activity, the amount of prayer was not associated with MCI or AD in either gender. Praying at midlife is associated with lower risk of mild cognitive impairment in women.

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Section: Methodsmentioning

confidence: 99%

Prayer at Midlife is Associated with Reduced Risk of Cognitive Decline in Arabic Women

Inzelberg

Afgin²,

Massarwa³

et al. 2013

CAR

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“…

Comment lent than Parkinson's disease in Arabic villagers in Israel (ET prevalence = 0.78% vs. PD prevalence = 1.44%) [12] ; however, those results are atypical.The incidence of ET has been examined in only 2 studies [13,14] . The incidence rate reported for ET, based on a populationbased study (the NEDICES study) [13] , was substantially higher (6.3 per 1,000 person-years) than that reported in the first published incidence study of ET that used data from Rochester Minnesota (0.58 per 1,000 among individuals aged 60-69 years, 0.76 per 1,000 among individuals aged 70-79 years, and 0.84 per 1,000 among individuals aged 80 years or more) [14] .

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confidence: 58%

How Common Is Essential Tremor?

Benito‐León¹

2009

Neuroepidemiology

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“…The Israeli-Arab population studied herein is remarkable for a high prevalence of dementia, low levels of schooling and high consanguinity rates [2, 3]. Additionally, while the prevalence of PD is similar to that described in Western countries (1.4%), the frequency of action tremor (1.8%) and essential tremor (0.8%) is unusually low [4]. In this study, we examined whether mild parkinsonian signs (MPS) and which MPS item-clusters are associated with mild cognitive impairment (MCI) and/or conversion from MCI to Alzheimer’s disease (AD).…”

Section: Introductionmentioning

confidence: 82%

Mild Cognitive Impairment is Associated with Mild Parkinsonian Signs in a Door-to-Door Study

Israeli‐Korn

Massarwa

Schechtman

et al. 2010

JAD

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Mild Cognitive Impariment (MCI) and healthy aging have been shown to be associated with Mild Parkinsonian Signs (MPS). We performed a door-to-door observational and follow-up study amongst consenting residents of Wadi Ara Arab villages in northern Israel aged ≥ 65 years (n = 687) to examine whether MPS represent a risk factor for MCI and/or conversion from MCI to Alzheimer’s disease (AD). In Phase 1, 223 cognitively normal (CN) and 173 MCI subjects were assessed by interview for medical history, neurological examination, motor part of the Unified Parkinson Disease Rating Scale (mUPDRS) (divided into item-clusters: axial, limb bradykinesia, tremor and rigidity) and cognitive tests. MCI subjects (n = 111) were reevaluated in Phase 2 for conversion to AD at least one year after initial assessment. MCI subjects had a higher frequency of axial dysfunction (8.7% vs. 1.3%) and limb bradykinesia (10.4% vs. 1.3%) than CN subjects (p < 0.001, both). Stepwise logistic regression analysis estimating the probability of MCI vs. CN revealed higher mUPDRS (OR = 1.19, 95% CI, 1.05 to 1.35, p = 0.006) and higher limb bradykinesia scores (OR = 1.75, 95% CI, 1.2 to 2.56, p = 0.003) and not age as explanatory variables. Presence of MPS did not predict conversion to AD after adjustment for age and time-interval. These results suggest that axial and bradykinetic parkinsonian signs represent risk factors for MCI but MPS may not predict conversion from MCI to AD.

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Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages

Cited by 26 publications

References 31 publications

Prayer at Midlife is Associated with Reduced Risk of Cognitive Decline in Arabic Women

Prayer at Midlife is Associated with Reduced Risk of Cognitive Decline in Arabic Women

How Common Is Essential Tremor?

Mild Cognitive Impairment is Associated with Mild Parkinsonian Signs in a Door-to-Door Study

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