How Common Is Essential Tremor?

Benito‐León, Julián

doi:10.1159/000195692

Cited by 33 publications

(22 citation statements)

References 19 publications

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“…Essential tremor (ET) is one of the most common adult neurological disorders, 1 yet its pathogenesis is not well understood. 2–4 The weight of emerging evidence is indicating that, aside from motor manifestations, ET is also associated with a number of nonmotor manifestations, including cognitive deficits, 5 dementia, 6 depressive symptoms, 7 changes in sleep patterns, 8 changes in visual reaction time, 9 and hearing impairment.…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity in Essential Tremor

et al. 2015

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Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function.Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected.Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability. Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability.ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of disease.

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Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity in Essential Tremor

et al. 2015

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“…Essential tremor (ET), whose core clinical feature is a progressive kinetic tremor of the arms, is one of the most common neurological diseases [1] . There are 28 population-based prevalence studies [2] and, based on these studies, it is clear that the crude prevalence (0.4%, all ages) rises markedly with age, reaching values of 6.3% among those 6 65 years of age and 21.7% amongst those 6 95 years [2] .…”

Section: Introductionmentioning

confidence: 99%

Association between Essential Tremor and Other Neurodegenerative Diseases: What Is the Epidemiological Evidence

LaRoia¹,

Louis²

2011

Neuroepidemiology

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Background: The possible links between essential tremor (ET) and Parkinson’s disease (PD) and, more recently, between ET and Alzheimer’s disease (AD) have been of great interest, particularly with the emergence of postmortem data suggesting that ET itself may be a neurodegenerative disease. Given the very high population prevalence of ET, its possible role as a risk factor for PD and AD is of special significance. At the center of this debate is the burgeoning evidence from epidemiological studies, examining whether there is an increased co-occurrence of these conditions within the same individuals or within families. Methods: We conducted a PubMed search from 1966 to March 2011 and reviewed the epidemiological evidence, restricting our analyses to studies that generated quantifiable measures of association (odds ratios or relative risks), thereby being able to assess the role of chance. Results: The most robust evidence, from case-control, prospective and familial aggregation studies, indicates that ET is associated with increased odds and increased risks of both PD and AD. Conclusions: There is reasonable epidemiological evidence to support a link between ET and these neurodegenerative diseases. Further studies are needed to corroborate the current results, provide additional estimates of effect and begin to explore the mechanistic underpinnings for these intriguing associations.

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“…Essential tremor (ET) is one of the most common neurological diseases 1,2. Traditionally, it has been considered a benign and monosymptomatic disorder characterized primarily by kinetic tremor in the arms.…”

Section: Introductionmentioning

confidence: 99%