Essential properties of drug-targeting delivery systems

Development of Dioctadecyldimethylammonium Bromide/Monoolein Liposomes for Gene Delivery

“…Amphiphiles with hydrophilic headgroups could be chemically linked to molecules such as folate, transferrin or the epidermal growth factor that potentiate specific delivery to cancer cells, markedly increasing the therapeutic benefits achieved with lipoplexes, with little secondary effects [114][115][116][117][118].…”

Challenges of Drug Delivery

“…Solubility, for example, is one of the leading factors hindering oral absorption and reducing bioavailability, and a great deal of effort is being put into determining methods to increase solubility of therapeutics in aqueous environments [63]. For example, chemical modifications to the drug molecules to generate prodrugs with increased aqueous solubility are being explored, as are methods of solid dispersion.…”

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“…The idea of developing a drug that selectively destroy disease cells without damaging healthy cells was proposed by Paul Ehrlich, almost a century ago; he called his hypothetical drug the "magic bullet" [17][18][19] . Thereafter, over the past several decades, many scientists have focused their attention on the development of ideal drugs that specifically target the site of action.…”