Essential Oils from Fruits and Leaves of Kielmeyera coriacea: Antitumor Activity and Chemical Study

Abstract

Kielmeyera coriacea, a typical tree species of the Cerrado (Brazilian Savanna), popularly known as "pausanto" and it is used in traditional medicine for the treatment of various diseases. This study aimed to chemically characterize the essential oils of leaves and fruits of K. coriacea and to evaluate its antitumor activity against human tumor cell lines MDA-MB-231 (breast tumor) and DU-145 (prostate tumor) as a way to search for new drugs derived from natural sources. Essential oils were extracted by hydrodistillation in Clevenger. The average yield of essential oil of leaves and fruits was 0.38% and 0.0041%, respectively. In leaves from K. coriacea, the major compounds found in the essential oils, were geranyl linalool (27,78), 2-Acetate (2E) Tridecenol (9.06%), E-nerolidol (7.70%) and α-bisabolol (5,09). The major compounds found in essential oils of fruits were D-germacrene (18.94%), neointermedeol (12.18%), bicyclogermacrene (12.00%), Viridiflorol (9,30 %), Globulol (8,76%), Epi-α-muurolol (8,13%) a d δ-cadinene (5,00%).. The essential oils of fruits inhibited the proliferation of tumor cell lines DU-145 and MDA-MB-231, as well as of the non-tumor cells (FH-Human fibroblasts). By contrast the essential oils of leaves were not active in any tested tumor lineage. To our knowledge, this is the first report on the chemical composition and antitumor activity of this species, and it clearly enhance our chemical knowledge of this plant.

ATIVIDADE ANTITUMORAL IN VITRO DE Prosopis Juliflora FRENTE A CÉLULAS DE CÂNCER DE MAMA E CÂNCER DE OVÁRIO

“…As manipulações das culturas celulares foram realizadas em câmara de fluxo laminar vertical, de acordo com a metodologia descrita por Lemes et al (2017).…”