Essential oils and their components are a class of antifungals with potent vapour-phase-mediated anti-Candida activity

Feyaerts, Adam F.; Mathé, Lotte; Luyten, Walter; Graeve, Stijn De; Dyck, Katrien Van; Broekx, Lize; Dijck, Patrick Van

doi:10.1038/s41598-018-22395-6

Cited by 28 publications

(17 citation statements)

References 52 publications

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“…The results of López et al (2007) indicate, that trans-cinnamaldehyde, the main compound of this oil might be responsible for its antimicrobial activity. Another in vitro experiment of Feyaerts et al (2018) carried out with 175 EOs confirmed the previous observation. The authors' results showed, that the EOs which contain high amount of aldehydes, had the highest inhibitory effect in vapour phase.…”

Section: Introductionsupporting

confidence: 86%

In vitro activity of the cinnamon essential oil against the plant pathogen Septoria melissae desm.

et al. 2018

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Septoria leafspot caused by the mitosporic fungus Septoria melissae Desm. is the most significant disease of lemon balm (Melissa officinalis L.). The fungus frequently appears in the plantations and causes serious yield losses or decreases the quality of the drug. At present plant protection of lemon balm is inadequate due to the lack of authorised plant protection products. The essential oil of the cinnamon bark (CEO) has a strong antimicrobial activity proved by several in vitro experiments. Therefore the goal of our work was to test antifungal effect of the CEO against the pathogen Septoria melissae Desm. In vitro tests were carried out with three concentrations (0.3%, 0.1%, 0.03%) of the CEO against a Hungarian and a Polish isolate of the fungus. Inhibition of the germination of the conidia as well as the mycelial radial growth was investigated. Supplementary tests were carried out with colonies of the fungi transferred to growth media without CEO after an incubation period of 14 and 35 days on media containing CEO. Our results showed that all the applied concentrations of CEO have very strong (98.07-100%) inhibitory effect on the mycelial growth of both isolates. Germination of conidia was also blocked on each medium containing CEO. However, the effect of the CEO at 0.03% concentration was reversible. Mycelium began to grow again on media without CEO after transfer. Based on the results, further investigation of CEO as a potential plant protection product in lemon balm crops is recommended.

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Section: Introductionsupporting

confidence: 86%

In vitro activity of the cinnamon essential oil against the plant pathogen Septoria melissae desm.

et al. 2018

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“…By screening a large collection of essential oils it was shown that ‘paradoxical like phenotypes’ were caused by small volatile molecules released from adjacent wells. This observation led to the development of a quantitative method to evaluate the activity of volatile molecules in the vicinity 59 .…”

Section: Methods For Antifungal Susceptibility Testing Of Planktonic mentioning

confidence: 99%

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Dijck¹,

Sjollema²,

Cammue³

et al. 2018

Microb Cell

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Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.

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“…Chemical composition, quality and origin of the EOs were certified by the company. The reduction from 188 EOs to our final set of 175 is essentially due to deduplication 54 . EOs were considered different when originating from (i) other plant species, (ii) the same plant species but from other plant parts, (iii) the same plant species but a different chemotype, and (iv) certified-organic versus conventional cultivation.…”

Section: Materials and Methods Essential Oils (Eos)mentioning

confidence: 99%

“…The detection of organophosphorus and organochlorine pesticides residue levels was in compliance with the relevant EU-legislation and maximum permitted levels were never exceeded 56 . The chemical composition (≥10%) and metadata of the EOs used in this study was reported previously; see www.nature.com/articles/s41598-018-22395-6 under the heading electronic supplementary material 54 . More detailed analysis certificates and the methodology used (in French) can be consulted at www.inula-group.com/fr/pranaquality (see also SI 1).…”

Section: Materials and Methods Essential Oils (Eos)mentioning

confidence: 99%

Striking essential oil: tapping into a largely unexplored source for drug discovery

Feyaerts

Luyten

Dijck

2020

Sci Rep

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Essential oils (EOs) have been used therapeutically for centuries. In recent decades, randomized controlled (clinical) trials have supported efficacy in specific therapeutic indications for a few of them. Some EOs, their components or derivatives thereof have been approved as drugs. Nevertheless, they are still considered products that are mainly used in complementary and alternative medicine. eo components occupy a special niche in chemical space, that offers unique opportunities based on their unusual physicochemical properties, because they are typically volatile and hydrophobic. Here we evaluate selected physicochemical parameters, used in conventional drug discovery, of EO components present in a range of commercially available EOs. We show that, contrary to generally held belief, most EO components meet current-day requirements of medicinal chemistry for good drug candidates. Moreover, they also offer attractive opportunities for lead optimization or even fragment-based drug discovery. Because their therapeutic potential is still under-scrutinized, we propose that this be explored more vigorously with present-day methods.Over the past few decades, drug discovery has shifted mainly to high-throughput screening of large chemical libraries while research on natural products has diminished 1,2 . Reasons for this are among others: (i) the legitimate concerns about the United Nations Convention on Biological Diversity and the Nagoya protocol which regulates the sovereign rights of genetic resources, resulting in many years of legal uncertainty regarding derived rights 3,4 . (ii) The difficulty of patent protection for natural products, especially since the publication of the "Guidance for Determining Subject Matter Eligibility of Claims Reciting or Involving Laws of Nature, Natural Phenomena, & Natural Products" 5,6 . (iii) The belief that natural products are somehow incompatible with high-throughput screening, and (iv) that they are difficult to isolate or synthesize 7 . At the same time, some compound collections are designed to mimic natural products, because these also offer clear advantages; for example, they exhibit a wide range of pharmacophores, show a high degree of stereochemistry and are metabolite-like 2,4,8-13 . However, recent technical developments and increased legal certainty have led to a renewed interest in natural product drug discovery 1,2,4,7,12,[14][15][16] . This is further strengthened by the 2015 Nobel Prize in Physiology or Medicine for natural product research on artemisinin; a sesquiterpene lactone with anti-malarial properties from the plant Artemisia annua, and on avermectins; macrocyclic lactones with potent anthelmintic and insecticidal properties derived from the soil bacterium Streptomyces avermitilis 7,17 .Companies have made great efforts to increase the chemical diversity of their compound collections used for drug discovery, but at the same time to reduce especially late-stage attrition; as a result the composition of these collections is increasingly shaped, or even dictat...

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Essential oils and their components are a class of antifungals with potent vapour-phase-mediated anti-Candida activity

Cited by 28 publications

References 52 publications

In vitro activity of the cinnamon essential oil against the plant pathogen Septoria melissae desm.

In vitro activity of the cinnamon essential oil against the plant pathogen Septoria melissae desm.

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Striking essential oil: tapping into a largely unexplored source for drug discovery

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