Essential Oil with Anticancer Activity: An Overview

Angelini, Paola; Tirillini, Bruno; Akhtar, Mohd Sayeed; Dimitriu, Luminita; Bricchi, Emma; Bertuzzi, Gianluigi; Venanzoni, Roberto

doi:10.1007/978-981-10-8064-7_9

Cited by 16 publications

(12 citation statements)

References 117 publications

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“…Although commonly used as a spice, especially in Asian cuisine, Cymbopogon representatives are also used as insect repellents (e.g., C. nardus (L.) Rendle) and soil conservatives, among others. Cymbopogon, as a therapeutic agent, has been used throughout human history for anti-inflammatory [10,11], antibacterial [12][13][14], antihelmintic [15], antiproliferative [16][17][18], antihyperlipidemic and antihyperglycemic [19] purposes. These properties are attributed mainly to the essential oils (EOs) that Cymbopogon species contain.…”

Section: Introductionmentioning

confidence: 99%

Composition, Anti-MRSA Activity and Toxicity of Essential Oils from Cymbopogon Species

et al. 2021

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Many of the essential oils obtained from medicinal plants possess proven antimicrobial activity and are suitable for medicinal purposes and applications in the food industry. The aim of the present work was the chemical analysis of 19 essential oils (EOs) from seven different Cymbopogon species (C. nardus, C. citratus, C winterianus, C. flexuosus, C. schoenanthus, C. martinii, C. giganteus). Five different chemotypes were established by GC/MS and TLC assay. The EOs, as well as some reference compounds, i.e., citronellol, geraniol and citral (neral + geranial), were also tested for their antimicrobial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) by the microdilution method and direct bioautography. The toxicity of EOs was evaluated by Danio rerio ‘Zebrafish’ model assay. All examined EOs showed moderate to high activity against MRSA, with the highest activity noted for C. flexuosus—lemongrass essential oil, both in microdilution and direct autobiography method. Significant difference in the toxicity of the examined EOs was also detected.

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Section: Introductionmentioning

confidence: 99%

Composition, Anti-MRSA Activity and Toxicity of Essential Oils from Cymbopogon Species

et al. 2021

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“…The anticancer potential of essential oils has been widely studied, aiming to mitigate the resistance development to multiple drugs and side effects associated with antitumor drugs currently used [ 81 ]. Essential oils of E. egensis, E. flavescens, E. patrisii, E. polystachya and E. uniflora showed cytotoxic activity against human cancer cell lines.…”

Section: Biological Activitiesmentioning

confidence: 99%

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

et al. 2020

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The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and biological activity, we are reporting the essential oils of 48 species of these two genera, which grow in South America and found mainly in Brazil. Chemically, a total of 127 oil samples have been described and displayed a higher intraspecific and interspecific diversity for both Eugenia spp. and Syzygium spp., according to the site of collection or seasonality. The main volatile compounds were sesquiterpene hydrocarbons and oxygenated sesquiterpenes, mainly with caryophyllane and germacrane skeletons and monoterpenes of mostly the pinane type. The oils presented many biological activities, especially antimicrobial (antifungal and antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive and anti-inflammatory. These studies can contribute to the rational and economic exploration of Eugenia and Syzygium species once they have been identified as potent natural and alternative sources to the production of new herbal medicines.

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“…The constituents of EOs have a wide range of molecular arrangements that include monoterpene and sesquiterpene hydrocarbons, monoterpenoids, sesquiterpenoids, phenylpropanoids, aliphatic compounds (alcohol, aldehydes), and some heterocyclic compounds. All these molecules are low in molecular weight, lipophilic, and highly volatile under normal conditions, and act as antiseptics, analgesics, anti-inflammatory agents, antiproliferative agents, sedatives, anesthetics, and spasmolytics [9,10]. Most of the volatile constituents have a direct effect on molecular pathways, especially on the inflammatory signaling cascade, which involves the participation of nitric oxide, receptors such as opioids, and others [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils

Caballero-Gallardo

Quintero-Rincón

Stashenko

et al. 2022

Plants

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Photoprotective agents obtained from plants provide benefits for the health of the skin. The present study aims to assess the total phenolic content (TPC) and in vitro UV-protective properties of twelve essential oils (EOs) from plants grown in Colombia and to evaluate the antioxidant and cytotoxic potential of two species identified as photoprotective potentials: Cymbopogon flexuosus and Tagetes lucida. The composition of EOs was studied by GC/MS. The cytotoxicity of both EOs was examined using an MTT assay, and an H2-DCFDA probe was employed to estimate the intracellular production of ROS in HepG2 and Calu-1 cells. Major constituents (≥10%) were neral, geranial, geranyl acetate in C. flexuosus and estragole in T. lucida. The TPC for C. flexuosus and T. lucida EOs were ≥10 mg GAE/g byproduct. Both EOs showed photoprotective properties (SPFin vitro: 13–14), and long-wavelength UVA protection (λc > 370 nm). HepG2 and Calu-1 cells exposed to C. flexuosus exhibited antiproliferative activity (˂50%) at 125 µg/mL, while T. lucida was at 250 and 500 µg/mL. The IC50 values for C. flexuosus were 75 and 100 µg/mL in HepG2 and Calu-1 cells, respectively, whereas those for T. lucida were >250 µg/mL. These EOs achieved significant inhibitory effects (between 15.6 and 40.4%) against H2O2-induced oxidative stress. The results showed that EO compounds recognized as antioxidants could counteract the effects elicited by H2O2.

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Essential Oil with Anticancer Activity: An Overview

Cited by 16 publications

References 117 publications

Composition, Anti-MRSA Activity and Toxicity of Essential Oils from Cymbopogon Species

Composition, Anti-MRSA Activity and Toxicity of Essential Oils from Cymbopogon Species

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

Photoprotective Agents Obtained from Aromatic Plants Grown in Colombia: Total Phenolic Content, Antioxidant Activity, and Assessment of Cytotoxic Potential in Cancer Cell Lines of Cymbopogon flexuosus L. and Tagetes lucida Cav. Essential Oils

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