Essential oil variability of Minthostachys verticillata

Zygadlo, Julio Alberto; Maestri, Damián; Lamarque, Alicia L.; Guzmán, Carlos; Velasco‐Negueruela, Arturo; Pérez‐Alonso, María José; García-Vallejos, María C.; Grosso, Nelson

doi:10.1016/0305-1978(96)00030-0

Cited by 30 publications

(29 citation statements)

References 4 publications

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“…The MIC values obtained for R-limonene, S-limonene, myrcene, sabinene, α-pinene, and β-elemene tested alone suggest that acyclic, monocyclic, and/or bicyclic structure and the number of double bonds have no significant influence on the antimycobacterial activity of monoterpenes. Similar findings were reported in a previous study [11] but a higher activity for aromatic and/or oxygenated monoterpenes was obtained than for the corresponding carbonyl compounds [12] . Equally important, quantitative structure-activity relationship (QSAR) studies revealed that the number of conjugated carbons, the number of phenolic and hydroxyl groups, and the number of acceptor atoms of hydrogen bonds are the most important structural descriptors in the antimycobacterial activity of terpenes [4] .…”

Section: Discussionsupporting

confidence: 79%

Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis

Sieniawska

Swatko-Ossor²,

Sawicki³

et al. 2016

Med Princ Pract

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Objective: In this study, we aimed to describe the influence of natural terpenes on the antimycobacterial activity of first-line tuberculostatic drugs against isolated Mycobacterium tuberculosis. Materials and Methods: The natural terpenes used in this study were R-limonene, S-limonene, myrcene, sabinene, α-pinene, and β-elemene. The values of the minimum inhibitory concentration (MIC) for these terpenes, as well as for combinations of terpenes with tuberculostatic antibiotics (ethambutol, isoniazid, and rifampicin), were determined using a tube log₂ dilution method in the range of 125-0.059 µg/mL. Results:S-limonene had a strong synergistic effect with all tested antibiotics (MIC decreased from 16 to 0.475 µg/mL for ethambutol, from 16 to 0.237 µg/mL for rifampicin, and from 32 to 0.475 µg/mL for isoniazid). Combinations of myrcene, R-limonene, β-elemene, and sabinene with tuberculostatic antibiotics resulted in a decreased MIC of the antibiotics (from 3.9 to 0.475 µg/mL for ethambutol, from 15 to 0.475 µg/mL for isoniazid, and from 0.475 to 0.237 µg/mL for rifampicin) while combinations of α-pinene with ethambutol and isoniazid resulted in increased MIC values (from 16 to 125 µg/mL for ethambutol, and from 32 to 125 µg/mL for isoniazid). Rifampicin had a synergistic increase in activity with all the tested compounds. Conclusions: Our study showed that terpenes enhance the activity of tuberculostatic antibiotics.

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Section: Discussionsupporting

confidence: 79%

Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis

Sieniawska

Swatko-Ossor²,

Sawicki³

et al. 2016

Med Princ Pract

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“…On the one hand, ever more substances have been identified to be present in small amounts, among them carvone, ␣-pinene, piperitenone, sabinene, myrcene, and (E)-␤-ocimene (de Feo et al, 1998). On the other hand, oil composition appears to be subject to high intraspecific variability (see Section 4.3 for more detail), with some samples very much pulegone-dominated (Manfredini and Montes, 1962;Ruffinengo et al, 2005;Primo et al, 2001;González Pereyra et al, 2005), and others even having carvone, thymol or carvacrol as the principal component (Lizzi and Retamar, 1975;Zyglado et al, 1996).…”

Section: Essential Oils and Other Chemical Componentsmentioning

confidence: 96%

“…Analyses of aromatic oil composition in Minthostachys verticillata indicate a correspondingly high diversity, but a higher variation between populations than within (Ojeda et al, 2004b) and a higher variation between regions of Argentina than within (Zyglado et al, 1996). In a single study of this one species (Zyglado et al, 1996), menthone content varied between 3.8 and 29.6%, limonene between 1.4 and 25.0%, pulegone between 1.2 and 47.0%; thymol and carvacrol were only found in populations from one region (Catamarca), but there they were of major importance (10.5-31.8 and 25.3-34.0%, respectively). Retamar et al (1995) found their samples from Tucumán dominated by carvone and those from Córdoba dominated by pulegone and menthone.…”

Section: Variability In Oil Compositionmentioning

confidence: 96%

Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae)

Schmidt‐Lebuhn

2008

Journal of Ethnopharmacology

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“…The monoterpenes pulegone and menthone accounted for about 70%. 44,51 The leaves that had been mined or were growing on gall-bearing stems revealed significantly decreased concentrations, whereas both categories of undamaged leaves (mined or were growing on gall-bearing stems had similar concentrations of pulegone. This speaks to a chemical defense reaction against insectinduced galls and other lesions.…”

Section: Plant Defense Systems Against Herbivoresmentioning

confidence: 99%

Animal plant warfare and secondary metabolite evolution

Wöll

Kim

Greten

et al. 2013

Nat. Prod. Bioprospect.

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Abstract:The enduring discussion, why plants produce secondary metabolites with pharmacologically and toxicologically active towards mammals traces back to the eminent role of medicinal plants in the millennia-old history of manhood. In recent years, the concept of an animal plant warfare emerged, which focused on the co-evolution between plants and herbivores. As a reaction to herbivory, plants developed mechanical defenses such as thorns and hard shells, which paved the way for adapted animal physiques. Plants evolved further defense systems by producing chemicals that exert toxic effects on the animals that ingest them. As a result of this selective pressure, animals developed special enzymes, e.g. cytochrome P450 monooxigenases (CYP450) that metabolize xenobiotic phytochemicals. As a next step in the evolutionary competition between plants and animals, plants evolved to produce non-toxic pro-drugs, which become toxic only after ingestion by animals through metabolization by enzymes such as CYP450. Because these sequestered evolutionary developments call to mind an arms race, the term animal plant warfare has been coined. The evolutionary competition between plants and animals may help to better understand the modes of action of medicinal plants and to foster the efficient and safe use of phytotherapy nowadays.

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Essential oil variability of Minthostachys verticillata

Cited by 30 publications

References 4 publications

Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis

Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis

Ethnobotany, biochemistry and pharmacology of Minthostachys (Lamiaceae)

Animal plant warfare and secondary metabolite evolution

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