Essential Oil Poisoning

Woolf, Alan D.

doi:10.1081/clt-100102450

Cited by 91 publications

(69 citation statements)

References 24 publications

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“…The increased use of essential oils worldwide has raised serious concerns with respect to their eventual adverse health and environmental effects, still waiting to be confirmed. [158] Yet one of the most attractive aspects of using essential oils and their constituents as crop protectors is their low mammalian toxicity. [34,126] Many of the essential oils and their constituents are commonly used as culinary herbs and spices, and therefore, pesticide products containing some of these compounds are most probably exempt from toxicity.…”

Section: Health and Environmental Impact Of Essential Oilsmentioning

confidence: 99%

The use of essential oils for postharvest decay control. A review.

Antunes

Cavaco

2010

Flavour & Fragrance J

133

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Food safety is one of the major issues related to fresh fruit and vegetables. The preservation of the 'freshness' quality of these products is relevant due to their economical impact. This chapter is a comprehensive review of the use of essential oils from different sources and their constituents on the control of postharvest decay and overall quality preservation of fresh fruit and vegetables. An overview on the most significant postharvest diseases and their impact, as well as on the mainly used synthetic chemicals and their side-effects has been included. Emphasis has been on the sources of essential oils and their constituents studied up to now, and their effects on controlling postharvest diseases, either in vitro or in vivo, and their effect on overall quality and storage life of fresh commodities. Issues regarding their impact on human health and the environment have also been analysed.

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Section: Health and Environmental Impact Of Essential Oilsmentioning

confidence: 99%

The use of essential oils for postharvest decay control. A review.

Antunes

Cavaco

2010

Flavour & Fragrance J

133

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“…Thus, considering that some essential oils and/or its constituents can present toxic effects, as well as misuse, can cause serious poisoning (Woolf, 1999), the present study was designed to assess the cytotoxic (by the MTT assay) and genotoxic potential (by the comet assay and micronucleus test) of geraniol, in an in vitro protocol, using two human cell types: i) human peripheral blood mononuclear cells (PBMC), and ii) human hepatoma cell line (HepG2), respectively, to evaluate its direct effects and after liver enzymes metabolization. …”

Section: Introductionmentioning

confidence: 99%

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

et al. 2017

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ABSTRACT. Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations, this study was designed to evaluate the cytotoxic and genotoxic potential of geraniol, in an in vitro protocol, using two types of human cells: one without the ability to metabolize (peripheral blood mononuclear cells -PBMC), and the other with this capability (human hepatoma cell line -HepG2) through the comet assay and the micronucleus test. Four concentrations (10, 25, 50, and 100 µg/ mL) were selected for the genotoxic assessment for PBMC and three (1.25, 2.5, and 5 µg/mL) for HepG2 cells based on cytotoxicity tests (MTT assay). Results showed that geraniol did not present genotoxic or clastogenic/aneugenic effects on both cell types under the conditions studied. However, caution is advised in the use of this substance by humans, since a significant reduction in viability of HepG2 and a marked decrease in cell viability on normal PBMC were verified.

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“…Clinical studies about the topical use of eucalyptus essential oil demonstrate that it is tolerated well both when inhaled and when applied onto the skin in topical formulations. However, the ingestion of a few milliliters of essential oils may cause severe symptoms of intoxication like vomiting, respiration failure, and unconsciousness and may lead to death, especially when infants are concerned (Woolf 1999).…”

mentioning

confidence: 99%

Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill. from Montenegro

Damjanovic-Vratnica¹,

Đakov²,

Šuković³

et al. 2011

Czech J. Food Sci.

104

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Damjanović-Vratnica B., Đakov T., Šuković D., Damjanović J. (2011): Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill. from Montenegro. Czech J. Food Sci., 29: 277-284.Chemical composition of the essential oil of Eucalyptus globulus Labill., grown in Montenegro, was analysed by gas chromatography-mass spectrometry and its antimicrobial activity was evaluated against 17 microorganisms, including food poisoning and spoilage bacteria and human pathogens.The Eucalyptus essential oil yield was 1.8% (w/w) on the fresh weight basis, whereas the analysis resulted in the identification of a total of 11 constituents, 1.8 cineole (85.8%), α-pinene (7.2%), and β-myrcene (1.5%) being the main components. Other compounds identified in the oil were β-pinene, limonene, α-phellandrene, γ-terpinene, linalool, pinocarveol, terpinen-4-ol, and α-terpineol. The results of the antimicrobial activity tests revealed that the essential oil of E. globulus has rather a strong antimicrobial activity, especially against Streptococcus pyogenes, Escherichia coli, Candida albicans, Staphylococcus aureus, acinetobacter baumannii, and klebsiella pneumoniae. Minimum inhibitory concentration revealed the lowest activity against Pseudomonas aeruginosa and Salmonela infantis (3.13 mg/ml) while the highest activity was against S. aureus, E. coli, and S. pyogenes (0.09 mg/ml).

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Essential Oil Poisoning

Cited by 91 publications

References 24 publications

The use of essential oils for postharvest decay control. A review.

The use of essential oils for postharvest decay control. A review.

Research Article Cytotoxic and genotoxic potential of geraniol in peripheral blood mononuclear cells and human hepatoma cell line (HepG2).

Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill. from Montenegro

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