Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system

Smeriglio, Antonella; Alloisio, Susanna; Raimondo, Francesco María; Denaro, Marcella; Xiao, Jianbo; Cornara, Laura; Trombetta, Domenico

doi:10.1016/j.fct.2017.12.053

Cited by 59 publications

(65 citation statements)

References 36 publications

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“…TEAC assay was carried out according to Smeriglio et al (). Briefly, the reaction mixture was incubated for 12–16 hr in the dark at RT, and then it was diluted with water to reach an absorbance at 734 nm of 0.7 ± 0.02.…”

Section: Methodsmentioning

confidence: 99%

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Smeriglio

Bonasera

Germanò

et al. 2019

Phytotherapy Research

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The aim of this work was to investigate the phytochemical profile and biological properties of different colours of betalain cactus pear extracts, evaluating their antioxidant, cytoprotective, and anti‐angiogenic properties by cell‐free, cell‐based, and in vivo assays. A QuEChERS extraction method followed by RP‐LC‐DAD‐MS/MS analysis showed that indicaxanthin and betanin were the main compounds (≥94.32% and ≥96.95%, respectively). Orange cactus pear extracts exert the best antioxidant activity in all assays carried out, in particular into ORAC (17,352.55 ± 987.407 mg trolox equivalents/100 g dry weight) and β‐carotene bleaching (60.35%) assays. The red ones, instead, showed the best cytoprotective activity decreasing the cell mortality, LDH, and Caspase‐3 release ranging from 4.0 to 55%. According to antioxidant results, the orange cactus pear extracts showing also the highest anti‐angiogenic activity (IC50 19.31 μg/ml), followed by the red (IC50 23.55 μg/ml) and the yellow ones (IC50 33.97 μg/ml). In light of the results and correlation analysis, the behaviour of these molecules varies a lot according to their structure and physicochemical features and synergistic activity between betalain classes may be postulated; so the plant complex could be of greater interest compared with the isolated molecules for potential nutraceutical and pharmaceutical uses.

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Section: Methodsmentioning

confidence: 99%

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Smeriglio

Bonasera

Germanò

et al. 2019

Phytotherapy Research

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“…FRAP assay was performed according to Smeriglio et al . Briefly, 50 μL of ACE (1.25–20 μg mL −1 ) were added to 1 mL of fresh daily working FRAP reagent, pre‐warmed at 37 °C, and the absorbance was read at 593 nm after 5 min using an UV/VIS spectrophotometer (Shimadzu UV‐1601, Kyoto, Japan).…”

Section: Methodsmentioning

confidence: 99%

“…FRAP assay was performed according to Smeriglio et al [21] Briefly, 50 μL of ACE (1.25-20 μg mL À 1 ) were added to 1 mL of fresh daily working FRAP reagent, pre-warmed at 37°C, and the absorbance was read at 593 nm after 5 min using an UV/VIS spectrophotometer (Shimadzu UV-1601, Kyoto, Japan). Results were expressed as inhibition (%) of the radical activity calculating the half-maximal inhibitory concentration (IC 50 ) with the respective confident limits at 95 %.…”

Section: Ferric Reducing Antioxidant Power (Frap) Assaymentioning

confidence: 99%

Polyphenol Characterization, Antioxidant and Skin Whitening Properties of Alnus cordata Stem Bark

Smeriglio

D’Angelo

Denaro

et al. 2019

Chemistry & Biodiversity

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In this study, we investigated the phenolic composition of the crude extract (MeOH 80 %) of Alnus cordata (Loisel.) Duby stem bark (ACE) and its antioxidant and skin whitening properties. RP‐LC‐DAD analysis showed a high content of hydroxycinnamic acids (47.64 %), flavanones (26.74 %) and diarylheptanoids (17.69 %). Furthermore, ACE exhibited a dose‐dependent antioxidant and free‐radical scavenging activity, expressed as half‐maximal inhibitory concentration (IC50): Oxygen radical absorbance capacity (ORAC, IC50 1.78 μg mL−1)>Trolox equivalent antioxidant capacity (TEAC, IC50 3.47 μg mL−1)>2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH, IC50 5.83 μg mL−1)>β‐carotene bleaching (IC50 11.58 μg mL−1)>Ferric reducing antioxidant power (FRAP, IC50 17.28 μg mL−1). Moreover, ACE was able to inhibit in vitro tyrosinase activity (IC50 77.44 μg mL−1), l‐DOPA auto‐oxidation (IC50 39.58 μg mL−1) and in an in vivo model it exhibited bleaching effects on the pigmentation of zebrafish embryos (72 h post fertilization) without affecting their development and survival. In conclusion, results show that A. cordata stem bark may be considered a potential source of agents for the treatment of skin disorders due to its bleaching properties and favorable safety profiles, associated to a good antioxidant power.

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“…Reinforcing this information, treatment with Schinus terebinthifolius essential oil-which is highly-concentrated in limonene-showed anti-hyperalgesic and anti-depressive effects in a neuropathic pain animal model [110]. At a different point-of-view, Smeriglio and colleagues reported the antioxidant and free radical scavenging properties of Citrus lumia oil, which is highly-concentrated in monoterpenes (e.g., 48.9% D-limonene and 18.2% linalool), suggesting an important preventive role in the genesis of oxidative stress-related pathologies [111]. In this context, a study conducted by Shin et al showed that limonene decreased cell death, ROS levels, extracellular signal-regulated kinase phosphorylation, and overall inflammation in the brains and eyes of drosophila during Aβ42-induced neurotoxicity, a model of Alzheimer's disease (AD) [104].…”

Section: D-limonenementioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

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Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

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Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system

Cited by 59 publications

References 36 publications

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Opuntia ficus‐indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti‐angiogenic properties

Polyphenol Characterization, Antioxidant and Skin Whitening Properties of Alnus cordata Stem Bark

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

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