Polyphenol Characterization, Antioxidant and Skin Whitening Properties of <i>Alnus cordata</i> Stem Bark

Smeriglio, Antonella; D’Angelo, Valeria; Denaro, Marcella; Trombetta, Domenico; Raimondo, Francesco María; Germanò, Maria Paola

doi:10.1002/cbdv.201900314

Cited by 15 publications

(14 citation statements)

References 23 publications

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“…Antioxidant and skin whitening properties were demonstrated in Alnus cordata by Smeriglio et al, in 2019 [ 97 ]. Analyzing the phenolic composition, a significant presence of flavanones (26.74%), such as epicatechin, orientin, isovitexin, naringenin and eriodictyol was shown, therefore confirming that zebrafish is a useful model for the in vivo analysis of anti-melanogenesis agents.…”

Section: Effects Of Flavonoids Employing Zebrafish As Experimental Modelmentioning

confidence: 99%

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

et al. 2021

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The zebrafish is considered one of the most versatile experimental animal models. The transparency of the embryos, the small size, the rapid development and the homology with higher vertebrates have made the zebrafish a valuable model also for drug screening. Its use is closely related for the determination of bioactivity, toxicity and off-target side effects of novel drug candidates, which also allows a thorough evaluation of new targets; thus, it may represent a suitable model for drug screening and the optimization of novel candidates. Flavonoids are polyphenolic compounds widely present in fruits, vegetables and cereals. Polyphenols are important for both plants and humans, considering their involvement in defense mechanisms, particularly against oxidative stress. They protect plants from biotic and abiotic stressors and prevent or treat oxidative-based human diseases. For these reasons, polyphenols are used as nutraceuticals, functional foods and supplements by the pharmaceutical industry. Therefore, the most relevant findings on zebrafish as a useful experimental model to study oxidative stress-linked disorders, focusing on the biological activities of flavonoids, are here summarized and reviewed.

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Section: Effects Of Flavonoids Employing Zebrafish As Experimental Modelmentioning

confidence: 99%

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

et al. 2021

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“…[16] with minor modifications. [24] Briefly, aliquots (0.05 mL) of sample at various concentrations (2-80 μM) were mixed with 0.5 mL of l-tyrosine or l-DOPA solution (1.25 mM), 0.9 mL of sodium acetate buffer solution (0.05 M, pH 6.8) and preincubated at 25°C for 10 min. Then 0.05 mL of an aqueous solution of mushroom tyrosinase (333 U/mL) was added last to the mixture.…”

Section: Mushroom Tyrosinase Inhibition Assaymentioning

confidence: 99%

4‐Fluorobenzylpiperazine‐Containing Derivatives as Efficient Inhibitors of Mushroom Tyrosinase

et al. 2020

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Tyrosinase is a type‐3 copper protein involved in the biosynthesis of melanin pigments; therefore, the inhibition of its enzymatic activity represents a promising strategy for the treatment of hyperpigmentation‐related disorders. To address this point, we previously designed a class of 4‐(4‐fluorobenzyl)piperazin‐1‐yl‐based compounds, which proved to be more active inhibitors against tyrosinase from mushroom Agaricus bisporus than the positive control kojic acid. Herein, we report the synthesis of further series of 4‐(4‐fluorobenzyl)piperazin‐1‐yl analogues bearing a (hetero)aromatic fragment as key feature to improve protein affinity. The newly synthesized compounds were assayed in vitro and proved to be potent inhibitors in the low‐micromolar range. The active 2‐thienyl and 2‐furyl derivatives were selected for further modification to allow their binding mode to be analyzed by docking studies and to give satisfactory safety profiles.

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“…The anti-tryptic activity was evaluated according to Smeriglio et al (2020). In brief, 200 μl of the test sample (7.81-62.50 μg/ml and 15.625-125 μg/ml for PEs and FEs, respectively; 31.25-250 μg/ml and 125-1,000 μg/ml for betanin and indicaxanthin, respectively) was added to the reaction mixture consisting of 12 μl trypsin (10 μg/ ml) and 188 μl Tris-HCl buffer (25 mM, pH 7.5).…”

Section: Protease Inhibition Assaymentioning

confidence: 99%

Prickly Pear Betalain-Rich Extracts as New Promising Strategy for Intestinal Inflammation: Plant Complex vs. Main Isolated Bioactive Compounds

et al. 2021

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Recently, many studies have highlighted the health effects of betalains beyond their use as food dyes. The present study investigated betalain-rich extracts with different colors and their main bioactive compounds in order to provide first evidence as a new promising strategy for intestinal inflammation management. Prickly pear betalain–rich extracts, obtained by a QuEChERS method, have been characterized by LC-DAD-ESI-MS/MS analysis. The potential role of betanin, indicaxanthin, and prickly pear extracts in counteracting the antioxidant and anti-inflammatory events was evaluated by several in vitro cell-free and cell-based assays. Indicaxanthin and betanin represent the most abundant compounds (≥22.27 ± 4.50 and 1.16 ± 0.17 g/100 g dry extract, respectively). Prickly pear extracts showed the strongest antioxidant and anti-inflammatory activities with respect to the pure betalains both on in vitro cell-free and cell-based assays, demonstrating the occurrence of synergistic activity, without any cytotoxicity or alteration of the barrier systems. The release of reactive oxygen species (ROS) and key inflammatory markers (IL-6, IL-8, and NO) was strongly inhibited by both betalains and even more by prickly pear extracts, which showed a similar and sometimes better profile than the reference compounds trolox and dexamethasone in counteracting the IL-1β–induced intestinal inflammation.

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Polyphenol Characterization, Antioxidant and Skin Whitening Properties of Alnus cordata Stem Bark

Cited by 15 publications

References 23 publications

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

4‐Fluorobenzylpiperazine‐Containing Derivatives as Efficient Inhibitors of Mushroom Tyrosinase

Prickly Pear Betalain-Rich Extracts as New Promising Strategy for Intestinal Inflammation: Plant Complex vs. Main Isolated Bioactive Compounds

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