Essential oil from Pterodon emarginatus seeds ameliorates experimental autoimmune encephalomyelitis by modulating Th1/Treg cell balance

Alberti, Thaís; Marcon, Rodrigo; Bicca, Maíra A.; Raposo, Nádia Rezende Barbosa; Calixto, João B.; Dutra, Rafael C.

doi:10.1016/j.jep.2014.05.044

Cited by 29 publications

(16 citation statements)

References 46 publications

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“…In this respect, demyelination is evident in the CNS results from a T cell‐mediated autoimmune response, especially encephalitogenic Th17 and Th1 cells (Wagner & Goverman, ). Work of Alberti et al () revealed that BCAR rich EO from Pterodon emarginatus at 50 and 100 mg/kg (p.o.) ameliorates autoimmune encephalomyelitis by modulating the Th1/Treg cell balance in Swiss mice.…”

Section: Neuropharmacological Effects Of β‐Caryophyllenementioning

confidence: 99%

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Machado

Islam

Ali

et al. 2018

Phytotherapy Research

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Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study reviews published reports pertaining to the neuropharmacological activities of BCAR. Databases such as PubMed, Scopus, MedLine Plus, and Google Scholar with keywords "beta (β)-caryophyllene" and other neurological keywords were searched. Data were extracted by referring to articles with information about the dose or concentration/route of administration, test system, results and discussion, and proposed mechanism of action. A total of 545 research articles were recorded, and 41 experimental studies were included in this review, after application of exclusion criterion. Search results suggest that BCAR exhibits a protective role in a number of nervous system-related disorders including pain, anxiety, spasm, convulsion, depression, alcoholism, and Alzheimer's disease.Additionally, BCAR has local anesthetic-like activity, which could protect the nervous system from oxidative stress and inflammation and can act as an immunomodulatory agent. Most neurological activities of this natural product have been linked with the cannabinoid receptors (CBRs), especially the CB2R. This review suggests a possible application of BCAR as a neuroprotective agent.

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Section: Neuropharmacological Effects Of β‐Caryophyllenementioning

confidence: 99%

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Machado

Islam

Ali

et al. 2018

Phytotherapy Research

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“…A meta-analysis showed that individuals born in autumn have a high risk of MS, based on their exposure to UV light and vitamin D levels [20]. Studies show that the risk of the disease decreases with diets low in salt and fat and with the use of essential oils from Pterodon emarginatus , a Brazilian legume [21]. …”

Section: Introductionmentioning

confidence: 99%

Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?

Adamczyk-Sowa

Medrek

Madej

et al. 2017

Journal of Immunology Research

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Aim. Evaluation of the impact of gut microflora on the pathophysiology of MS. Results. The etiopathogenesis of MS is not fully known. Gut microbiota may be of a great importance in the pathogenesis of MS, since recent findings suggest that substitutions of certain microbial population in the gut can lead to proinflammatory state, which can lead to MS in humans. In contrast, other commensal bacteria and their antigenic products may protect against inflammation within the central nervous system. The type of intestinal flora is affected by antibiotics, stress, or diet. The effects on MS through the intestinal microflora can also be achieved by antibiotic therapy and Lactobacillus. EAE, as an animal model of MS, indicates a strong influence of the gut microbiota on the immune system and shows that disturbances in gut physiology may contribute to the development of MS. Conclusions. The relationship between the central nervous system, the immune system, and the gut microbiota relates to the influence of microorganisms in the development of MS. A possible interaction between gut microbiota and the immune system can be perceived through regulation by the endocannabinoid system. It may offer an opportunity to understand the interaction comprised in the gut-immune-brain axis.

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“…β-Elemene regulates the immune balance through the blood-brain barrier [126], inhibits the downregulation of Treg cells and Th17 and Th1 polarization, and downregulates the expression of the proinflammatory factor IL-17, which has a substantial protective effect on optic nerve inflammation in experimental autoimmune encephalomyelitis [127]. In an experimental autoimmune encephalomyelitis mouse model, we observed that β-elemene selectively downregulated CD4+ T lymphocytes without affecting the activation of peripheral lymphoid tissue, significantly weakened the signs in the nervous system and the development of experimental autoimmune encephalomyelitis (EAE), inhibited the Th1 cell-mediated immune response, and upregulated the Treg cell response in vitro [128]. Improvement of EAE by β-elemene may depend on inhibition of IL-6activated RORγt signal transduction, the STAT3 pathway, and promotion of Treg cell proliferation to inhibit the development and differentiation of Th17 cells [129].…”

Section: β-Elemene Protects Immune Disordersmentioning

confidence: 96%

“…Elemene treatment of NCI-H292 cells, a human lung adenocarcinoma cell line, increased the levels of p38 mitogenactivated protein kinase (MAPK) and iNOS, and so, a locally increased concentration of NO may be associated with elemene-induced apoptosis [140]. In a mouse model of experimental autoimmune encephalomyelitis, elemene restrained microglial activation and iNOS expression, which was associated with the inhibition of axonal demyelination and neuronal death during the development of the disease [128]. β-Elemene effectively downregulates iNOS expression and inhibits NO production; furthermore, inhibition of iNOS leads to a decrease in PGE2 synthesis and downregulation of COX-2 expression, which indicates that elemene has strong anti-inflammatory activity in LPS-stimulated macrophages [107,141].…”

Section: β-Elemenementioning

confidence: 99%

The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

Xie

Lei

et al. 2020

BioMed Research International

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Inflammatory mediators and inflammatory cells in the inflammatory microenvironment promote the transformation of normal cells to cancer cells in the early stage of cancer, promote the growth and development of cancer cells, and induce tumor immune escape. The monomeric active ingredient β-elemene is extracted from the traditional Chinese medicine Curcuma wenyujin and has been proven to have good anti-inflammatory and antitumor activities in clinical applications for more than 20 years in China. Recent studies have found that this traditional Chinese medicine plays a vital role in macrophage infiltration and M2 polarization, as well as in regulating immune disorders, and it even regulates the transcription factors NF-κB and STAT3 to alter inflammation, tumorigenesis, and development. In addition, β-elemene regulates not only different inflammatory factors (such as TNF-α, IFN, TGF-β, and IL-6/10) but also oxidative stress in vivo and in vitro. The excellent anti-inflammatory and antitumor effects of β-elemene and its ability to alter the inflammatory microenvironment of tumors have been gradually elaborated. Although the study of monomeric active ingredients in traditional Chinese medicines is insufficient in terms of quality and quantity, the pharmacological effects of more active ingredients of traditional Chinese medicines will be revealed after β-elemene.

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Essential oil from Pterodon emarginatus seeds ameliorates experimental autoimmune encephalomyelitis by modulating Th1/Treg cell balance

Cited by 29 publications

References 46 publications

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?

The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

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