Essential Oil Constituents of<i>Tanacetum cilicicum</i>: Antimicrobial and Phytotoxic Activities

Ulukanlı, Zeynep; Demirci, Salih Cercis; Yılmaztekin, Murat

doi:10.1155/2017/6214896

Cited by 12 publications

(7 citation statements)

References 30 publications

(33 reference statements)

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“…Numerous Tanacetum species produce essential oils that are known to have antibacterial activity including T. balsamita , T. polycephalum , T. parthenium , T. longifolium , and T. cilicicum [ 35 , 36 , 37 ]. Antibacterial activity of T. vulgare from Roumania [ 9 ] and Slovakia [ 38 ] were also reported against gram-positive bacterial strains using the disc diffusion method.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

et al. 2017

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Background: Tanacetum vulgare L. (Asteraceae) is a perennial herb that has been used to treat multiple ailments. Regional variability of the chemical composition of T. vulgare essential oils is well-known. Despite these regional chemotypes, most relevant studies did not analyze the complete chemical composition of the T. vulgare essential oil and its constituents in relation to their biological activities. Here, we assess the anti-inflammatory, antioxidant, antibacterial, and cytotoxic activities of T. vulgare collected from northern Quebec (Saguenay-Lac-St-Jean), Canada. Methods: Essential oil was extracted from plants by steam distillation and analyzed using GC-FID. Biological activities of essential oil and its main constituents were evaluated in vitro. Results: We identified the major compounds as camphor, borneol, and 1,8-cineole. The oil possesses anti-inflammatory activity inhibiting NO production. It also inhibits intracellular DCFH oxidation induced by tert-butylhydroperoxide. Anti-inflammatory activity of essential oil appears driven mainly by α-humulene while antioxidant activity is provided by α-pinene and caryophyllene oxide. Essential oil from T vulgare was active against both Escherichia coli and Staphylococcus aureus with camphor and caryophyllene oxide responsible for antibacterial activity. Finally, T. vulgare essential oil was slightly cytotoxic against the human healthy cell line WS1 while α-humulene and caryophyllene oxide were moderately cytotoxic against A-549, DLD-1, and WS1. Conclusion: We report, for the first time, links between the specific compounds found in T. vulgare essential oil and anti-inflammatory, antioxidant, antibacterial, and cytotoxic activities. T. vulgare essential oil possesses interesting biological properties.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

et al. 2017

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“…As reported in [ 48 ], T. vulgare extracts have antibacterial activity [ 48 , 49 , 50 ]. The antibacterial activity of T. vulgare from Romania [ 51 ] and Slovakia [ 52 ] against strains of Gram-positive bacteria using the disk diffusion method has also been reported.…”

Section: Discussionmentioning

confidence: 97%

In Vitro Study of Biological Activity of Tanacetum vulgare Extracts

et al. 2023

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Tanacetum vulgare is an herbaceous plant widely used in folk medicine. It is rich in phenolic acids and flavonoids, which have pharmacological and medicinal properties, such as anthelmintic, antispasmodic, tonic, antidiabetic, diuretic, and antihypertensive. This study aimed to confirm the presence of biologically active substances in Tanacetum vulgare and to determine the pharmacological spectrum of biological activity of Tanacetum vulgare extract components. When preparing Tanacetum vulgare extracts, the highest yield was observed when using the maceration method with a mixture of solvents methanol + trifluoroacetic acid (22.65 ± 0.68%). The biologically active substances in Tanacetum vulgare extract samples were determined using high-performance liquid chromatography. Biologically active substances such as luteolin-7-glucoside (550.80 mg/kg), chlorogenic acid (5945.40 mg/kg), and rosmarinic acid (661.31 mg/kg) were identified. Their structures were determined. The experiments have confirmed the antioxidant and antibacterial activities. Secondary metabolites of Tanacetum vulgare extracts have been found to have previously unknown biological activity types; experimental confirmation of their existence will advance phytochemical research and lead to the development of new drugs.

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“…It has been demonstrated in previous study that different parts of T. cilicicum contain p-coumaric acid, ferulic acid, gallic acid, gentisic acid, chlorogenic acid, quercetin, naringenin and catechin [18]. Tanacetum species also contain essential oil (α-pinene, sabinene, limonene, eucalyptol, camphor, linalool, α-terpineol, borneol) and sesquiterpene lactones as secondary metabolites [19][20][21].…”

Section: Introductionmentioning

confidence: 96%

Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson

Şen

Doğan

Bitiş

2019

International Journal of Secondary Metabolite

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In this study, various extracts obtained different parts of Tanacetum cilicicum were investigated for in vitro antioxidant and anti-inflammatory activity. Antioxidant activity was tested with three methods; namely 2.2diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, 2.2′-azinobis (3ethylbenzothiazolin-6-sulphonic acid) (ABTS) radical cation scavenging capacity, and ferric-reducing antioxidant power (FRAP) assays. Total phenolic and flavonoid contents of extracts were determined by Folin-Ciocalteu and aluminum chloride methods, respectively. Also, anti-inflammatory activity of these extracts was evaluated by 5-lipoxygenase inhibition assay. Ethyl acetate extract of capitula of T. cilicicum (TCCEA) showed the highest antioxidant activity with IC50 values of 22.44 and 30.86 µg/mL against DPPH and ABTS radicals, respectively. At the same time, the highest ferric reducing power was found in the TCCEA (42.2 mg TE/g extract). The highest total phenolic contents have been detected in TCCEA and ethyl acetate extract of leaves of T. cilicicum (TCLEA) with value of 174.1 and 175.6 mg GAE/g extract, respectively. Similarly, the highest total flavonoid contents have been detected in TCCEA and TCLEA with values of 26.94 and 30.48 mg QE/g extract, respectively. TCCEA exhibited strong anti-inflammatory activity with IC50 value of 9.44 µg/mL when compared to standard indomethacine (22.39 µg/mL). These results demonstrate that TCCEA has a significant antioxidant and anti-inflammatory activity. Also, the results show that TCCEA is a good candidate for further bioactivity-guided fractionation in the search for new active anti-inflammatory and antioxidant compounds.

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Essential Oil Constituents ofTanacetum cilicicum: Antimicrobial and Phytotoxic Activities

Cited by 12 publications

References 30 publications

Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

In Vitro Study of Biological Activity of Tanacetum vulgare Extracts

Antioxidant and anti-inflammatory activity of capitula, leaf and stem extracts of Tanacetum cilicicum (Boiss.) Grierson

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