Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

Côté, Héloïse; Boucher, Marie-Anne; Pichette, André; Legault, Jean

doi:10.3390/medicines4020034

Cited by 86 publications

(78 citation statements)

References 39 publications

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“…In addition, β-caryophyllene exogenously added inhibited the mitochondrial ROS production in murine BV2 cells. 46 The reduced gluconeogenesis from L-lactate in the perfused livers of arthritic rats was already verified, including from other substrates, and it has been reported to occur due to lower activity of gluconeogenic key enzymes. The fact that no change occurred in the ROS production and respiration of isolated mitochondria (Figure 3) does not disprove that the phenomenon occurs in vivo because incubations of isolated organelles do not reproduce these conditions, as inflammatory mediators and β-caryophyllene, for example, are absent.…”

Section: Discussionmentioning

confidence: 94%

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

Ames-Sibin

Barizão

Castro-Ghizoni

et al. 2018

J of Cellular Biochemistry

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The current study investigated the action of β-caryophyllene, the major constituent of copaiba oil, on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. This study also compared the actions of β-caryophyllene with those previously reported for copaiba oil on arthritic rats. For this purpose, Holtzman healthy and arthritic rats received 215 and 430 mg·kg β-caryophyllene orally once a day during 18 days. Both doses of β-caryophyllene reduced the adjuvant-induced paw edema, swollen of lymph nodes, and number of circulating and articular leukocytes. β-Caryophyllene, at the dose of 430 mg·kg , abolished the increases of protein carbonyl groups and myeloperoxidase activity in the liver and plasma of arthritic rats and, at both doses, it restored the increased levels of reactive oxygen species and reduced glutathione in the arthritic liver. These beneficial actions were of the same extension as those of copaiba oil ( Copaifera reticulata) and, therefore, β-caryophyllene is possibly responsible for the anti-inflammatory and antioxidant actions of the oil. Hepatic gluconeogenesis was 40% lower in arthritic rats, which also presented a reduced number of hepatocytes per liver area (-23%) associated with increased hepatocyte area (+18%) and liver weight (+50%). None of these hepatic alterations were improved by β-caryophyllene, but not even by ibuprofen. However, unlike copaiba oil, β-caryophyllene did not modify the hepatic morphology and metabolism of healthy rats. These results reveal that β-caryophyllene improves the systemic inflammation and oxidative status of arthritic rats and, in addition, it was not associated with hepatotoxicity.

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Section: Discussionmentioning

confidence: 94%

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

Ames-Sibin

Barizão

Castro-Ghizoni

et al. 2018

J of Cellular Biochemistry

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“…showed that the tested EO commercial aroma compounds (caryophyllene oxide, longifolene, nerolidol and davanone) inhibited the Gram‐positive bacteria. In fact, caryophyllene oxide is well‐known as preservative in food, drugs and cosmetics and was reported as responsible for the antibiotic activity of Tanacetum vulgare L. essential oil . Furthermore, Santos Patricia et al .…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Activity of Essential Oils of Carissa macrocarpa (Eckl.) A.DC. Cultivated in Tunisia and Its Anatomical Features

Souilem

Ayeb

Djlassi

et al. 2018

Chemistry & Biodiversity

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This is the first study investigating the chemical composition of essential oils (EOs) isolated from different tissues of Carissa macrocarpa (Eckl.) A.DC., their antimicrobial activity and the anatomical characters of the aerial organs and the fruits. The main EO components were pentadecanal and tetradecan-1-ol (31.9 and 16.5% in fresh leaf EO, respectively), (E)-nerolidol and caryophyllene oxide (27.3 and 15.0% in fruit EO, respectively), linalool and hexahydrofarnesyl acetone (30.9 and 24.9% in stem EO, respectively), benzyl benzoate (24.3% in flower EO). The fruit EO was more active against Candida albicans (MIC = 0.46 mg/mL) compared to the reference antibiotic (17.66 mg/mL). Furthermore, at this concentration it inhibited all the Gram-positive bacteria. Concerning the anatomical features, it is noteworthy to mention the presence of a large cluster of calcium oxalate crystals inside some parenchymatous cells. Large ducts corresponding to non articulated laticifers were identified in the cortex of leaf, stem and fruit pericarp. The laticifers categories and their distribution are taxonomically important to discriminate this species from others acclimated in different countries. Considering the obtained results, EOs of C. macrocarpa can be a good source of antimicrobial compounds, contributing to solve the problem of microbial resistance to antibiotics.

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“…Se ha informado que el alcanfor es uno de los agentes antimicrobianos más eficientes de varias plantas (Magiatis et al, 2002). La actividad antibacteriana del alcanfor ha sido reportada previamente en la literatura (Gupta y Saxena, 2010;Sokovic et al, 2010;Hsouna et al, 2013;Coté et al, 2017), y se ha señalado que el mecanismo de acción del alcanfor sobre el crecimiento de microorganismos incluye la desestabilización de la estructura de la bicapa fosfolipídica, la interacción con las enzimas y proteínas de la membrana y su acción como intercambiador de protones que reduce el gradiente de pH a través de la membrana (Xu et al, 2005). Contrario a esto, Kotan et al (2007) encontraron que el alcanfor fue inefectivo como antibacteriano.…”

Section: Discussionunclassified

Componentes químicos y actividad antimicrobiana del aceite esencial de <i>Lasiocephalus ovatus</i> (Asteraceae) que crece en Ecuador

et al. 2020

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Ecuador es uno de los países más ricos en biodiversidad y endemismo del mundo, y cerca de 3200 especies de plantas tienen usos medicinales. El objetivo de esta investigación fue evaluar la composición química y el efecto antimicrobiano del aceite esencial de Lasiocephalus ovatus Schltdl. (Asteraceae) colectada en la provincia de Chimborazo, Ecuador. Las partes aéreas de L. ovatus fueron sometidas a hidrodestilación para obtener el aceite esencial, el cual fue analizado mediante cromatografía de gases acoplada a espectrometría de masas. La actividad fue evaluada frente a cinco bacterias y una levadura usando la técnica de microdilución en caldo en microplacas de 96 pozos. El rendimiento del aceite fue de 0,05 % y 27 compuestos fueron identificados, representando 95,45 % de la composición total con un elevado contenido de monoterpenos oxigenados (52,17 %). Los compuestos mayoritarios fueron alcanfor (40,48 %) y 1,2,5,5-tetrametil-1,3-ciclopentadieno (11,90 %), seguido por p-menta-1,5-dien-8-ol (5,23 %) y 1,6-dimetilhepta-1,3,5-trieno (4,69 %). Las bacterias más sensibles a la acción del aceite fueron Staphylococcus aureus ATCC 25923 y Escherichia coli ATCC 25922 con concentraciones mínimas inhibitorias de 200-400 μg/mL y bactericidas de 800 μg/mL. La inhibición antimicrobiana frente a las bacterias Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 y la levadura Candida albicans ATCC 10231 fue baja, con un rango de concentración mínima inhibitoria de 800 a 6400 μg/mL. Este reporte representa un primer análisis de la actividad antimicrobiana del aceite de L. ovatus, por lo tanto, una contribución importante al estudio del género Lasiocephalus.

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Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents

Cited by 86 publications

References 39 publications

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress in arthritic rats

Chemical Composition and Activity of Essential Oils of Carissa macrocarpa (Eckl.) A.DC. Cultivated in Tunisia and Its Anatomical Features

Componentes químicos y actividad antimicrobiana del aceite esencial de <i>Lasiocephalus ovatus</i> (Asteraceae) que crece en Ecuador

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