Essential fatty acids and peptic ulcer disease.

Das, Undurti N.; Reddy, D. Nageshwar; Rao, Pragna; Vembu, Radha

doi:10.1136/gut.28.7.914

Cited by 12 publications

(2 citation statements)

References 8 publications

(3 reference statements)

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“…Essential fatty acids of both the ω3 and ω6 series have been shown to be protective against peptic ulceration in several rat models. 18–31 Epidemiological evidence also suggests that a high intake of linoleic acid is related to a low prevalence of duodenal ulceration. 32–35 …”

Section: Discussionmentioning

confidence: 99%

Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Jayaraj

Tovey

Lewin³

et al. 2000

J of Gastro and Hepatol

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The experiments confirm the presence of a lipid in certain staple foods that have protective and healing properties in experimental peptic ulcer animal models. The differences in the prevalence of duodenal ulceration between different regions in some developing countries with a high prevalence of Helicobacter pylori infection might be explained by the presence or absence of protective lipids or ulcerogenic factors in the staple diet.

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Section: Discussionmentioning

confidence: 99%

Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Jayaraj

Tovey

Lewin³

et al. 2000

J of Gastro and Hepatol

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“…Epidemiological evidence suggests that, as well as having a lower incidence of coronary artery disease, Eskimos and other communities with a high consumption of fish have a lower incidence of multiple sclerosis [52], breast cancer [46], peptic ulcer disease [53], psoriasis, asthma, diabetes and other autoimmune diseases [54].…”

Section: Introductionmentioning

confidence: 99%

Intensive Farming and Food Processing: Implications for Polyunsaturated Fats

Denton

Lacey

1991

Journal of Nutritional Medicine

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Intensive methods of rearing jish, broilers, egg layers and pigs can ryduce the proportion of cis polyunsaturated fatty acids (PUFAs) to saturatedfatty acids in the food. Irradiation, and deep fieezing and cook-chill systems may also reduce PUFAs. It is not known whether microwave exposure converts cis fatty acids to trans. We request that all food items produced by intensive farming and/or processing be regularly analyzed for PUFAs and labelled accordingly. Changes in the methods offeeding food animals, poultry and fib, and their processing, may be partly responsible for the continued high incidence of coronav heart disease.

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Dietary PUFA Increase Apoptosis in Stomach of Patients with Dyspeptic Symptoms and Infected with H. pylori

Sharifi

Nouri

Eidi

et al. 2017

Lipids

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Drug-resistant strains of Helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. Polyunsaturated fatty acids (PUFA) have an inhibitory effect on bacterial growth. The aim of this study was to investigate the effect of PUFA in combination with standard triple therapy on apoptosis in H. pylori infected subjects with dyspeptic symptoms. This study was a double-blind clinical trial in which 34 H. pylori infected subjects with dyspeptic symptoms were randomly divided into two groups of 17 patients. The control group received standard triple therapy (amoxicillin, clarithromycin and omeprazole) and the experimental group received the standard therapy and PUFA for two weeks. Gene expression levels of caspase-3, BCL-2 and Bad proteins were studied with real-time PCR, while protein levels were quantified in frozen sections and using immunohistochemistry. Compared with the control group, a significant increase (p < 0.01) was observed in the expression of caspase-3 and Bad genes and a significant reduction (p < 0.05) in the expression of Bcl-2 gene. The protein level of active caspase-3 and Bad protein was significantly increased and the level of Bcl-2 protein was significantly decreased (p < 0.05). The results of this study show that oral administration of PUFA in combination with the standard triple therapy increased apoptosis in H. pylori-infected patients with dyspeptic symptoms. This increase in apoptosis may partly reduce drug resistance in these patients. Our results suggest inclusion of a dietary PUFA containing fatty acid supplement may improve treatment of patients that are refractory to the standard triple therapy.

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Essential fatty acids and peptic ulcer disease.

Cited by 12 publications

References 8 publications

Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Intensive Farming and Food Processing: Implications for Polyunsaturated Fats

Dietary PUFA Increase Apoptosis in Stomach of Patients with Dyspeptic Symptoms and Infected with H. pylori

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