Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Jayaraj, A. P.; Tovey, F I; Lewin, M. R.; Clark, C. G.

doi:10.1046/j.1440-1746.2000.02214.x

Cited by 32 publications

(38 citation statements)

References 48 publications

(47 reference statements)

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“…Both the protective and also healing effect of the lipid extracts from horse gram in experimental peptic ulcer models has been reported (Jayaraj et al , 2000). Presented here are unpublished experiments extending over a period of 18 years in which free fatty acids, phospholipids, sterols and sterol esters from that lipid extract have been tested for protective activity against peptic ulceration using rat models producing gastric ulceration (pyloric ligation and ethanol) and duodenal ulceration (cysteamine).…”

Section: Introductionmentioning

confidence: 88%

“…Pyloric ligation was performed as by Shay et al (1945). Groups of rats were fed for 2 weeks on a South Indian diet based on rice or rice plus tapioca (Jayaraj et al, 2000(Jayaraj et al, , 2001. The rice diet is ulcerogenic and the rice plus tapioca even more so.…”

Section: Animal Modelsmentioning

confidence: 99%

“…In animal peptic ulcer models, unrefined wheat, wheat bran, some millets and pulses are protective (Jayaraj et al , 1980(Jayaraj et al , , 2000(Jayaraj et al , , 2001. Amongst the pulses, Dolichos biflorus (horse gram) showed marked protection.…”

Section: Introductionmentioning

confidence: 99%

“…In preliminary experiments petroleum ether, 70% ethanol and aqueous extracts from powdered horse gram were tested in the rat pyloric ligation model. The 70% ethanol extract was toxic, the watery extract was inert, but the petroleum ether extract was highly protective (Jayaraj et al , 1980(Jayaraj et al , , 2000.…”

Section: Introductionmentioning

confidence: 99%

“…Petroleum ether extracts from other protective foods were also shown to give protection in animal peptic ulcer models (Jayaraj et al , 1980(Jayaraj et al , , 2000(Jayaraj et al , , 2001.…”

Section: Introductionmentioning

confidence: 99%

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Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Jayaraj

Tovey

Hobsley

2003

Phytotherapy Research

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The varying geographical prevalence of duodenal ulceration has suggested a relationship to staple diet. Previous experiments on animal peptic ulcer models showed that certain foods, particularly the lipid fraction, are ulceroprotective. This paper reports experiments on animal models further to investigate the nature of the protective substances in the most active lipid, that of horse gram. The free fatty acids and triglycerides, sterols, sterol esters and phospholipids from horse gram were extracted and tested for protective activity on rat peptic ulcer models: the pyloric ligation model which is chronic, involving 14 days pre-feeding, and two acute models using ethanol or cysteamine to induce ulceration. The results showed that sterol esters, but not sterols, were protective in the pyloric ligation model. Sterols were protective in the acute models using ethanol-induced and cysteamine-induced ulceration. Phospholipids were protective in both types of model. The free fatty acids and triglycerides gave no protection using the pyloric ligation model. The presence of sterols, sterol esters and phospholipids in the lipid fraction of foods in staple diets may account for the low prevalence of duodenal ulcer in certain geographical areas, despite a uniformly high prevalence of Helicobacter pylori infection.

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Section: Introductionmentioning

confidence: 88%

Section: Animal Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Petroleum ether extracts from other protective foods were also shown to give protection in animal peptic ulcer models (Jayaraj et al , 1980(Jayaraj et al , , 2000(Jayaraj et al , , 2001.…”

Section: Introductionmentioning

confidence: 99%

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Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Jayaraj

Tovey

Hobsley

2003

Phytotherapy Research

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Dietary Phosphilipids and Sterols Protective against Peptic Ulceration

Tovey

Bardhan

Hobsley

2012

Phytotherapy Research

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The prevalence of duodenal ulceration in regions of developing countries with a stable diet is related to the staple food(s) in that diet. A higher prevalence occurs in areas where the diet is principally milled rice, refined wheat or maize, yams, cassava, sweet potato or green bananas, and a lower prevalence in areas where the staple diet is based on unrefined wheat or maize, soya, certain millets or certain pulses. Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration. The protective activity was found to lie in the phospholipid, sterol and sterol ester fractions of the lipid. Amongst individual phospholipids present in the phospholipid fraction, phosphatidyl ethanolamine (cephalin) and phosphatidyl choline (Lecithin) predominated. The sterol fraction showing activity contained β-sitosterol, stigmasterol and an unidentified isomer of β-sitosterol. The evidence shows that dietary phytosterols and phospholipids, both individually and in combination, have a protective effect on gastroduodenal mucosa. These findings may prove to be important in the prevention and management of duodenal and gastric ulceration including ulceration due to NSAIDs.

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Vigna unguiculata (L.) Walp (Fabaceae/Leguminosae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Duodenal ulcer prevalence: Experimental evidence for the possible role of dietary lipids

Cited by 32 publications

References 48 publications

Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Dietary Phosphilipids and Sterols Protective against Peptic Ulceration

Vigna unguiculata (L.) Walp (Fabaceae/Leguminosae)

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